Biological evaluation of polyvinyl alcohol hydrogel crosslinked by polyurethane chain for cartilage tissue engineering in rabbit model

Polyvinyl alcohol (PVA) hydrogel chains were crosslinked by urethane pre-polymer (PPU) in order to fabricate a new substitute for cartilage lesions. The microscopy images showed that the cultured chondrocytes had spherical morphology on PVA–PPU sample after 4 weeks of isolation in vitro. The alcian blue and safranin O staining proved the presence of proteoglycan on the surface of PVA–PPU sample secreted by cultured chondrocytes. This was confirmed by the detection of sulfate ions in the wavelength dispersive X-ray (WDX) analysis. In addition, the expression of collagen type II and aggrecan were observed in chondrocytes cultured on PVA–PPU by RT-PCR. Moreover, the implantation of the PVA–PPU sample with autologous cultured chondrocytes revealed the formation of neocartilage tissue in a rabbit model during 12 weeks follow up. In conclusion, the results verified that isolated chondrocytes cultured on PVA–PPU retain their original phenotype and this composition can be considered as promising substrate for cartilage tissue engineering.     

Continuance of mHealth services at the bottom of the pyramid: the roles of service quality and trust

Continued usage of information systems (or, IS continuance) has proven to be a critical success parameter for ICT implementation at the top of the global economic pyramid. However, there are few studies which have explored continued IS usage at the bottom of the economic pyramid (BOP) though it represents the majority of the world’s population. To fill this knowledge gap, this study develops an mHealth continuance model at the BOP framing the impact of two post adoption expectation beliefs (i.e., perceived service quality and perceived trust). This study extends ECM (expectation confirmation model) perspective synthesizing the extant literature on continued IS usage, service quality and consumer trust. The proposed model was empirically tested within the context of mHealth (mobile health) services at the BOP, applying PLS (partial least squares) under a cross sectional study. The findings confirm that both perceived service quality and perceived trust have significant explanatory power under an integrated ECM providing superior prediction of continuance intentions. The study concludes by discussing conceptual contributions, practical implications, limitations and future research directions.     

4- and 6-GS/s 4-bit frequency-translating hybrid ADCs in 90-nm CMOS

Two frequency-translating hybrid analog-to-digital converters (FTH-ADCs) are implemented using building blocks that are designed and fabricated in a 90-nm CMOS technology. These blocks include a mixer, a filter, and an ADC that are cascaded to build each analog processing path of the FTH-ADC. The mixer-filter path is designed with sufficient linearity and signal-to-noise-and-distortion ratio (SNDR) to accommodate for the desired resolution of the path ADC. A 4-bit flash ADC structure is used in each path. This path has a signal bandwidth of 0.5 GHz and frequency-translates the input signal into baseband and digitizes it with the sample rate of 2 GHz. Multiple such mixer-filter-ADC paths are then combined together with proper mixing frequencies in order to implement two- and three-channel ADC systems. The two- and three-channel systems have overall input bandwidths of 2 and 3 GHz and effective conversion rates of 4 and 6 GS/s, respectively, while maintaining their single-path resolution across their entire input bandwidths. The implemented architecture provides an extendible solution to improve the speed of ADCs by incorporating them in an FTH-ADC architecture.