Psychological impact of benign breast biopsy: A longitudinal, comparative study.

The impact of benign breast biopsy (BBB) on distress and perceptions of risk for breast cancer (BC) was examined. Interviews were conducted with 100 women shortly after notification of biopsy results and 4 and 8 months post-BBB. Compared with matched healthy comparison (HC) women without BBB, the BBB group evidenced greater BC-specific distress at baseline. BC-specific distress declined after BBB, remaining elevated relative to the HC group at the 8-month follow-up. Dispositional (optimism, informational coping style), demographic (education), clinical (family history of BC), and cognitive (BC risk perception) variables were associated with baseline levels of BC-specific distress or persistence of distress. Results support the monitoring process model (S. M. Miller, 1995) and the cognitive social health information processing model (S. M. Miller, Y. Shoda, & K. Hurley, 1996). (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Collaborative systems: Evolving databases and the “Conditions of possibility”-artificial life models of agency in on-line interactive art

This paper will discuss interactive on-line artworks modelled on cellular automata that employ various types of agents, both algorithmic and human, to assist in the evolution of their databases. These works constitute what will here be referred to as Collaborative Systems systems that evolve through the practice of inter-authorship.     

Enhancing the Therapeutic Potential of Mesenchymal Stromal Cell-Based Therapies with an Anti-Fibrotic Agent for the Treatment of Chronic Kidney Disease

Chronic kidney disease (CKD) affects 1 in 10 members of the general population, placing these patients at an increasingly high risk of kidney failure. Despite the significant burden of CKD on various healthcare systems, there are no effective cures that reverse or even halt its progression. In recent years, human bone-marrow-derived mesenchymal stromal cells (BM-MSCs) have been recognised as a novel therapy for CKDs, owing to their well-established immunomodulatory and tissue-reparative properties in preclinical settings, and their promising safety profile that has been demonstrated in patients with CKDs from several clinical trials. However, renal fibrosis (scarring), a hallmark of CKD, has been shown to impair the viability and functionality of BM-MSCs post-transplantation. This has suggested that BM-MSCs might require a pre-treatment or adjunct therapy that can enhance the viability and therapeutic efficacy of these stromal cells in chronic disease settings. To address this, recent studies that have combined BM-MSCs with the anti-fibrotic drug serelaxin (RLX), have demonstrated the enhanced therapeutic potential of this combination therapy in normotensive and hypertensive preclinical models of CKD. In this review, a critical appraisal of the preclinical data available on the anti-fibrotic and renoprotective actions of BM-MSCs or RLX alone and when combined, as a treatment option for normotensive vs. hypertensive CKD, is discussed.     

Symmetric self-electrooptic effect device: optical set-reset latch,differential logic gate, and differential modulator/detector

The symmetric self-electrooptic-effect device (S-SEED), a structure consisting of two p-i-n diodes electrically connected in series and acting as an optically bistable set-reset latch, is discussed. Applications and extensions of this device are also discussed. The devices do not require the critical biasing that is common to most optically bistable devices and thus is more useful for system applications. They have been optically cascaded in a photonic ring counter and have been used to perform different NOR, OR, NAND, and AND logic functions. Using the same device, a differential modulator that generates a set of complementary output beams with a single voltage control lead and a differential detector that gives an output voltage dependent on the ratio of the two optical input powers have been demonstrated     

Female-Headed Households and Achieving Home Ownership in Australia

This paper begins by identifying the growth in female-headed households in Australia. Despite this increase, it is argued that females still lag males in terms of home ownership rates (HORs) with women in Australia facing similar ownership challenges as those experienced in the UK and the USA. In seeking to establish any dynamic change, the study analyses female home ownership rates in Australia for two points in time, 1998 and 2008. Logit models are used to predict HORs. The results indicate that factors such as household type, income and source of income have an impact on rates of ownership. The paper concludes that female-headed households in Australia show an increasing propensity to purchase which match, or even exceed, those of male-headed households.     

Hydrogel/bioactive glass composites for bone regeneration applications: Synthesis and characterisation

Due to the deficiencies of current commercially available biological bone grafts, alternative bone graft substitutes have come to the forefront of tissue engineering in recent times. The main challenge for scientists in manufacturing bone graft substitutes is to obtain a scaffold that has sufficient mechanical strength and bioactive properties to promote formation of new tissue. The ability to synthesise hydrogel based composite scaffolds using photopolymerisation has been demonstrated in this study. The prepared hydrogel based composites were characterised using techniques including Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), Energy-dispersive X-ray spectrometry (EDX), rheological studies and compression testing. In addition, gel fraction, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), porosity and swelling studies of the composites were carried out. It was found that these novel hydrogel bioglass composite formulations did not display the inherent brittleness that is typically associated with bioactive glass based bone graft materials and exhibited enhanced biomechanical properties compared to the polyethylene glycol hydrogel scaffolds along. Together, the combination of enhanced mechanical properties and the deposition of apatite on the surface of these hydrogel based composites make them an ideal candidate as bone graft substitutes in cancellous bone defects or low load bearing applications.     

DNA-directed immobilization of horseradish peroxidase onto porous SiO2optical transducers

ABSTRACT: Multifunctional porous Si nanostructure is designed to optically monitor enzymatic activity of Horseradish Peroxidase. First, an oxidized PSi optical nanostructure, a Fabry-Perot thin film, is synthesized and is used as the optical transducer element. Immobilization of the enzyme onto the nanostructure is performed through DNA-Directed Immobilization. Preliminary studies demonstrate high enzymatic activity levels of the immobilized Horseradish Peroxidase, while maintaining its specificity. The catalytic activity of the enzymes immobilized within the porous nanostructure is monitored in real time by reflective interferometric Fourier transform spectroscopy. We show that we can easily regenerate the surface for consecutive biosensing analysis by mild de-hybridization conditions.     

Polychromic carbon black: Laser galvanized multicolour fluorescence display

Recovered carbon black (rCB), a very economical and abundance source of material, is transformed into dazzling multicolour fluorescence and visual display for the first time by way of a scanning focused laser treatment. This laser-initiated process is both straightforward and versatile, catering to both micro- and macro-scopic patterning with the sample in ambient or helium environment. The observed phenomenon is attributed to both chemical and structural induced colouration of rCB powder. Chemically, carbon infusion of oxidised metal occurs when photothermal reaction takes place in ambient. After laser modification with the sample in helium environment, the powder not only fluoresces due to sulphur impurities, control annealing of these powders results in formation of periodic arrangements of carbon nanoparticles. The periodicity of these arrangement falls within the range of visible wavelength, hence contributing to the visually observable rainbow coloured rCB flakes. The patterned sample is also transferrable using PDMS stamps. This in turn broadens the application of this material in flexible electronic devices/displays. Photocurrent measurements show most significant enhancement under yellow light illumination. Furthermore, in the presence of an applied potential, the fluorescence detected from the sample can easily be switched off. All in all, we present a simple process to add multiple functionalities to a material that is both inexpensive and sustainable.