A case of liver metastasis of gastric leiomyosarcoma successfully treated by transarterial hepatic chemo-embolization and intra hepato-arterial chemotherapy repeated with infusion-a-port

The patient was a 68-year-old male, who underwent total gastrectomy for giant leiomyosarcoma of the stomach and then had multiple hepatic metastases one year and six months later. Thus, transarterial hepatic chemo-embolization therapy with Lipiodol, adriamycin and gelfoam was given. Moreover, using a reservoir catheter and infusion arterial port, intermittent arterial infusion therapy with adriamycin, cyclophosphamide, and vincristine was attempted. In the metastasis lesion where there were rich blood vessels, Lipiodol was accumulated and the tumor was reduced on abdominal CT. The result indicated the efficacy of this treatment.     

A trypsin inhibitor trans-4-guanidinomethylcyclohexanecarboxylic acid 4-tert-butylphenyl ester suppresses the onset of DNA synthesis in Escherichia coli cells synchronized by phosphate starvation

The Resonant Frequency (RF) of the tibia is proportional to its stiffness. As a fractured tibia heals, its RF should increase. The RF was serially determined in 74 fractured tibias (205 examinations). These were subdivided by fracture location and fixation. Fast Fourier transform software generates the RF from data obtained with an instrumented impactor and accelerometer. The RF was normalized by expressing it as a ratio of the intact tibia. This ratio is called the tibial stiffness index (TSI). A 20 point tibial fracture score (TFS) quantitated the clinical and radiographic signs of healing. For each group the paired TSI and TFS were compared by regression analysis. Except for those fractures limited to the proximal fourth of the tibia, the TSI was found to correlate significantly (p = 0.0001) with the TFS. Fractures without fixation and those with unlocked, unreamed tibial nails showed very significant correlation of TSI with TFS (p = 0.0001). RF analysis was not useful in fractures with locked or reamed tibial nails. Examination of tibia with external fixation showed significant correlation (p = 0.02) of the TSI with the TFS.     

Risk factors for sensitisation to methyltetrahydrophthalic anhydride

OBJECTIVES: To examine an association between specific IgE to methyltetrahydrophthalic anhydride (MTHPA) and exposure time, atopic history, smoking habits, and total IgE concentrations. METHODS: A cross sectional survey was carried out on a population of 148 workers from two condenser plants using epoxy resin with MTHPA, an acid anhydride curing agent known to cause allergy. RESULTS: Using a Pharmacia CAP system with a MTHPA human serum albumin conjugate, specific IgE antibody was detected in serum from 97 (66%) out of the 148 workers exposed to MTHPA. Stepwise multiple linear regression analysis showed a striking relation between log concentrations of specific and total IgE (P < 0.0001). Furthermore, when the workers were divided into two groups according to a cut-off point (100 IU/ml) between low and high total IgE, current smoking was significantly (P = 0.025) associated with specific IgE production only in the group with low total IgE (< 100 IU/ml). CONCLUSIONS: Smoking is the most significant risk factor for raising specific IgE to MTHPA in the group with low total IgE concentrations.     

Prolonged discordant xenograft survival and delayed xenograft rejection in a pig-to-baboon orthotopic cardiac xenograft model

OBJECTIVE: Our objectives were to study delayed xenograft rejection and the effectiveness of pretransplantation total lymphoid irradiation combined with immunosuppression on rejection in a pig-to-baboon cardiac xenograft model. METHODS: Baboons were treated with pretransplantation total lymphoid irradiation, cyclosporine A (INN: ciclosporin), and methotrexate. Orthotopic pig-to-baboon cardiac transplantations were performed after depletion of circulating xenoreactive natural antibody by pretransplantation donor organ hemoperfusion. Tissue samples were collected for immunologic and immunopathologic evaluation. RESULTS: Pig cardiac xenografts survived more than 18 and 19 days without evidence of hyperacute rejection. Immunologic analysis of serum samples demonstrated that circulating xenoreactive natural antibody levels did not return to pretransplantation levels. The production of xenoreactive natural antibodies from the recipient's splenocytes was inhibited completely. Histologic examination of xenografts showed the feature of acute vascular rejection. Immunohistochemical studies demonstrated infiltration of cardiac xenografts by large numbers of macrophages, small numbers of natural killer cells, and a few T cells. The infiltrating macrophages also showed expression of interleukin-1 and tumor necrosis factor. Diffuse deposition of immunoglobulin G, C1Q, C3, and fibrin on xenograft vasculature was observed. Interleukin-2 expression was not found in rejected cardiac xenografts. Xenograft endothelial cells also showed evidence of activation (expression of cytokines interleukin-1 and tumor necrosis factor). CONCLUSIONS: This study demonstrates prolonged discordant cardiac xenograft survival and delayed xenograft rejection in a pig-to-baboon model. The delayed xenograft rejection is mediated by both humoral and cellular mechanisms. Pretransplantation total lymphoid irradiation combined with cyclosporine A and methotrexate can inhibit xenoreactive natural antibody production but not elicited antipig antibody production and the xenoreactivity of macrophages.     

Applications of genetic algorithm to aesthetic design of dam structures

In this paper, an attempt is made to develop a decision-making supporting system for the aesthetic design of dam structures. The present system is based on genetic algorithm and computer graphics. Genetic algorithm is able to produce many design alternatives, whereas computer graphics is useful to prepare their view simulations. In order to evaluate the alternatives, the analytical hierarchy process method is used to reflect the preference of designers. A numerical example of coloring a dam structure is presented to demonstrate the applicability of the system developed here.     

A new charge pumping method for determining the spatialdistribution of hot-carrier-induced fixed charge in p-MOSFETs

A charge pumping method is proposed for the direct measurement of the hot-carrier-induced fixed charge near the drain junction of p-MOSFETs. By holding the rising and falling slopes of the gate pulse constant and then varying the highest and lowest levels, the local threshold and local flatband voltages are readily obtained. The spatial distribution of fixed charges is directly calculated from the changes that occur in these curves after the application of stress. This method is quite simple and, specifically, requires no information about impurity concentrations in the substrate. The validity and reliability of the method have been supported by computer simulations