Towards locally and globally shape-aware reverse 3D modeling

The process of re-creating CAD models from actual physical parts, formally known as digital shape reconstruction (DSR) is an integral part of product development, especially in re-design. While, the majority of current methods used in DSR are surface-based, our overarching goal is to obtain direct parameterization of 3D meshes, by avoiding the actual segmentation of the mesh into different surfaces. As a first step towards reverse modeling physical parts, we extract (1) locally prominent cross-sections (PCS) from triangular meshes, and (2) organize and cluster them into sweep components, which form the basic building blocks of the re-created CAD model. In this paper, we introduce two new algorithms derived from Locally Linear Embedding (LLE) (Roweis and Sauk, 2000 [3]) and Affinity Propagation (AP) (Frey and Dueck, 2007 [4]) for organizing and clustering PCS. The LLE algorithm analyzes the cross-sections (PCS) using their geometric properties to build a global manifold in an embedded space. The AP algorithm, then clusters the local cross sections by propagating affinities among them in the embedded space to form different sweep components. We demonstrate the robustness and efficiency of the algorithms through many examples including actual laser-scanned (point cloud) mechanical parts.     

Sterile keratitis after corneal collagen crosslinking in a child

Corneal collagen crosslinking (CXL) is a non invasive technique used in halting the progression of keratoconus. Complications with this modality are rare. We report a case of an 8-year-old child who developed sterile infiltrates in the immediate postoperative period after uneventful corneal collagen crosslinking for keratoconus. The infiltrates resolved with topical steroid therapy. There was also present coexisting vernal keratoconjunctivitis (VKC) which was controlled with topical 2% cyclosporine A eye drops prior to crosslinking treatment. This case highlights importance of controlling VKC prior to CXL in keratoconus as it adds to the risk of developing post operative sterile keratitis.     

Mitotic Diversity in Homeostatic Human Interfollicular Epidermis

Despite decades of skin research, regulation of proliferation and homeostasis in human epidermis is still insufficiently understood. To address the role of mitoses in tissue regulation, we utilized human long-term skin equivalents and systematically assessed mitoses during early epidermal development and long-term epidermal regeneration. We now demonstrate four different orientations: (1) horizontal, i.e., parallel to the basement membrane (BM) and suggestive of symmetric divisions; (2) oblique with an angle of 45°–70°; or (3) perpendicular, suggestive of asymmetric division. In addition, we demonstrate a fourth substantial fraction of suprabasal mitoses, many of which are committed to differentiation (Keratin K10-positive). As verified also for normal human skin, this spatial mitotic organization is part of the regulatory program of human epidermal tissue homeostasis. As a potential marker for asymmetric division, we investigated for Numb and found that it was evenly spread in almost all undifferentiated keratinocytes, but indeed asymmetrically distributed in some mitoses and particularly frequent under differentiation-repressing low-calcium conditions. Numb deletion (stable knockdown by CRISPR/Cas9), however, did not affect proliferation, neither in a three-day follow up study by life cell imaging nor during a 14-day culture period, suggesting that Numb is not essential for the general control of keratinocyte division.     

Direct three dimensional tomography of flames using maximization of entropy technique

Presently, there are numerous applications for non-destructive techniques like emission tomography, laser based methods and particle image velocimetry that are used to study flame characteristics. Reconstruction of the flame intensity field using emission tomography has the advantage over other technologies that it gives accurate results but at the same time requires relatively inexpensive equipment, and therefore, has numerous industrial applications. In the present paper, a new algorithm performing Direct-3D reconstruction using the maximization of entropy (MENT) methodology has been introduced. Through detailed studies using a mathematical object, it has been shown that the Direct-3D algorithm shows significantly reduced errors as compared to 2D slice-by-slice reconstruction algorithms. Secondly, the major features of the proposed algorithm, for e.g., effect of orientation, effect of number of views, and robustness have been discussed. Finally, a few qualitative results from actual flames have been presented using a candle and a gas fired burner, and the results match well with the actual flame geometry and intensity distribution.     

Surface roughness optimization of cold-sprayed coatings using Taguchi method

In this paper, Taguchi L 18 orthogonal array have been employed for depositing the electro-conductive coatings by varying various process parameters, i.e., substrate material, type of powder feeding arrangement, stagnation gas temperature, stagnation gas pressure, and stand-off distance. The response parameter of the coatings so produced is measured in terms of surface roughness. The optimum process parameters are predicted on the basis of analyses (ANOVA) of the raw data and signal to noise ratio. The significant process parameters in order of their decreasing percentage contribution are: stagnation pressure, stand-off distance, substrate material, stagnation temperature of the carrier gas, and feed arrangement of the powder particles, respectively.     

Carbon nanotube-based electrochemical sensor for the determination of halobetasol propionate, a topical corticosteroid

Electrocatalytic reduction of halobetasol propionate (HBP) at single-walled carbon nanotube (SWCNT) modified edge plane pyrolytic graphite electrode (EPPGE) was performed by square wave voltammetry and cyclic voltammerty in phosphate buffer of pH 7.2. The surface morphology of SWCNT/EPPGE was characterized by field emission scanning electron microscopy. The enhanced peak current (i _p) and lower reduction peak potential (E _p) at modified electrode as compared to bare electrode were obvious evidences for the electrocatalytic ability of SWCNT toward the reduction of HBP. The cathodic peak current varied linearly with concentration of HBP in the range 0.02 to 1 mM with sensitivity of 2.432 μA mM⁻¹ and detection limit (3σ/slope) of 10 μM. The product of electrochemical reduction of HBP was characterized using FT-IR and ¹H-NMR spectroscopic techniques. A tentative mechanism for the formation of product was suggested and it was found that reduction of >C=O occurred at position three. The proposed methodology was successfully applied to the detection of HBP in pharmaceutical preparations.     

Flow Behaviour of Modified 9Cr–1Mo Steel at Elevated Temperatures

In this investigation, the flow behaviour of modified 9Cr–1Mo steel at elevated temperatures is reported. To understand the flow behaviour of the steel, tensile tests were performed at nominal strain rate of 3 × 10^?3 s^?1 and temperatures in the range of 300–823 K. The yield strength and ultimate tensile strength were found to decrease with increase in temperature with a plateau in a intermediate temperature regime (523–673 K). Serrations were also observed in the tensile curve at intermediate temperatures which caused plateau/peak in tensile behaviour of material and was a typical manifestation of dynamic strain ageing. An attempt was made to represent the flow behaviour of the material using different constitutive equations viz., Hollomon, Ludwik, Swift, Ludwigson and Voce. It was observed that the Voce equation could describe the experimental flow curve at different temperatures quite well. Instantaneous work hardening rate with respect to flow stress exhibited two stages of hardening especially at relatively lower temperatures.