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91.
Cystic dilation of the common bile duct is a rare congenital anomaly. The cases of two patients, 2 1/2 and 18 years old, respectively, illustrate the difficulty in preoperative diagnosis, as well as the value of long-term postoperative follow-up. Ascending cholangitis developed in one of the patients after a Roux-en-Y cystojejunostomy nine years after operation. A follow-up of three years after cystoduodenostomy and 14 years after a hepaticojejunostomy is reported. In infants and small children, a cystoduodenostomy is usually done; otherwise, cystojejunostomy should be the preferred initial operation. Excision may be attempted if the cyst is very small, and in selected cases.  相似文献   
92.
We consider a non-cooperative and symmetric three-stage game played by two regulator-firm hierarchies. We show that R&D spillovers and the competition of firms on the common market help non-cooperating countries to better internalize transboundary pollution. Surprisingly, international competition increases the per-unit emission-tax and decreases the per-unit R&D subsidy. It also leads to a higher investment in R&D and production, and to a lower emission ratio. In most cases, pollution in common market is lower than in autarky, implying a greater social welfare, and the contrary occurs in some other cases.  相似文献   
93.
Since the continuous proliferation of the journalistic content online and the changing political landscape in many Arabic countries, we started our current research in order to implement a media monitoring system about the opinion mining in political field. This system allows political actors, despite of the large volume of online data, to be constantly informed about opinions expressed on the web in order to properly monitor their actual standing, orient their communication strategy and prepare the election campaigns. The developed system is based on a linguistic approach using NooJ’s linguistic engine to formalize the automatic recognition rules and apply them to a dynamic corpus composed of journalistic articles. The first implemented rules allow identifying and annotating the different political entities (political actors and organizations). Then these annotations are used in our system of media monitoring in order to identify the opinions associated with the extracted named entities. The system is mainly based on a set of local grammars developed for the identification of different structures of the political opinion phrases. These grammars are using the entries of the opinion lexicon that contain the different opinion words (verbs, adjectives, nouns) where each entry is associated with the corresponding semantic marker (polarity and intensity). Our developed system is able to identify and properly annotate the opinion holder, the opinion target and the polarity (positive or negative) of the phraseological expression (nominal or verbal) expressing the opinion. Our experiments showed that the adopted method of extraction is consistent with 0.83 F-measure.  相似文献   
94.
Aquifer recharge rates and patterns are often uncertain, especially in arid areas due to sporadic and erratic rainfall. Therefore, determining the optimal groundwater abstraction using classical approaches such as Monte Carlo Simulation (MCS) requires a large number of groundwater simulations and exorbitant computational efforts. The problem becomes even more complex and time consuming for regional coastal aquifers whose domains must be discretized using high-resolution meshes. In fact, even fast evolutionary multi-objective optimization techniques generally require a large number of simulations to determine the Pareto-front among the objectives. This study explores the performance of a Decision Tree (DT) approach for the generation of the Pareto optimal solutions of groundwater extraction. This paper applies the DTs for the optimal management of the Al-Khoud coastal aquifer in Oman. The learning process of the developed DT-based model uses the output of a numerical simulation model to assess the aquifer response based on different abstraction policies. The trained DT network then utilizes the NSGA-II to determine the Pareto-optimal solutions. The simulation show that the general flux pattern in the study area is toward the sea and the hydraulic head following a similar pattern in both best and worst recharging scenarios downstream of the studied recharging dam. Statistical tests showed a good correlation between the DT-based and simulation-based results and demonstrate the capability of the DT approach to obtain high-quality solutions by incorporating a large number of recharge scenarios. Moreover, the required runtime of the DT-based approach is extremely low (5 min) compared to that of the simulation-based method (several days). This means that including additional Monte-Carlo simulations can be readily done in few minutes using the obtained DTs, instead of the long computational time needed by the simulation-based approach.  相似文献   
95.
    
ABSTRACT

Road crashes are present as an epidemic in road traffic and continue to grow up, where, according to World Health Organization; they cause more than 1.24 million deaths each year and 20 to 50 million non-fatal injuries, so they should represent by 2020 the third leading global cause of illness and injury. In this context, we are interested in this paper to the car-following driving behavior problem, since it alone accounts for almost 70% of road accidents, which they are caused by the incorrect judgment of the driver to keep a safe distance. Thus, we propose in this paper a decision-making model based on bi-level modeling, whose objective is to ensure the integration between road safety and the reducing travel time. To ensure this objective, we used the fuzzy logic approach to model the anticipation concept in order to extract more unobservable data from the road environment. Furthermore, we used the fuzzy logic approach in order to model the driver behaviors, in particular, the normative behaviors. The experimental results indicate that the decision to increase in velocity based on our model is ensured in the context of respecting the road safety.  相似文献   
96.
97.
  总被引:1,自引:0,他引:1  
This paper proposes a new robust fault reconstruction and estimation design for a class of nonlinear system described by the Takagi‐Sugeno model with unmeasurable premise variables subject to faults affecting actuators, sensor faults, and unknown disturbances. The augmented Takagi‐Sugeno system is introduced with a new fault vector which has two origins: the first one represents actuator faults, the second one denotes faults affecting sensors. The main contribution is focused primarily to conceive a sliding mode observer with two discontinuous terms designed to compensate for fault behavior and disturbance variation from the system states estimation. In the formalism of linear matrix inequalities, we derive sufficient conditions to guarantee the state estimation error stability and to obtain the observer gains. Meanwhile, additional effort is made to achieve simultaneous faults and disturbance reconstruction. Simulation results are given to illustrate the proposed approach performances.  相似文献   
98.
99.
    
Myeloproliferative neoplasms (MPNs) are a group of disorders characterized by clonal expansion of abnormal hematopoietic stem cells leading to hyperproliferation of one or more myeloid lineages. The main complications in MPNs are high risk of thrombosis and progression to myelofibrosis and leukemia. MPN patients with high risk scores are treated by hydroxyurea (HU), interferon-α, or ruxolitinib, a tyrosine kinase inhibitor. Polycythemia vera (PV) is an MPN characterized by overproduction of red blood cells (RBCs). ABCG2 is a member of the ATP-binding cassette superfamily transporters known to play a crucial role in multidrug resistance development. Proteome analysis showed higher ABCG2 levels in PV RBCs compared to RBCs from healthy controls and an additional increase of these levels in PV patients treated with HU, suggesting that ABCG2 might play a role in multidrug resistance in MPNs. In this work, we explored the role of ABCG2 in the transport of ruxolitinib and HU using human cell lines, RBCs, and in vitro differentiated erythroid progenitors. Using stopped-flow analysis, we showed that HU is not a substrate for ABCG2. Using transfected K562 cells expressing three different levels of recombinant ABCG2, MPN RBCs, and cultured erythroblasts, we showed that ABCG2 potentiates ruxolitinib-induced cytotoxicity that was blocked by the ABCG2-specific inhibitor KO143 suggesting ruxolitinib intracellular import by ABCG2. In silico modeling analysis identified possible ruxolitinib-binding site locations within the cavities of ABCG2. Our study opens new perspectives in ruxolitinib efficacy research targeting cell types depending on ABCG2 expression and polymorphisms among patients.  相似文献   
100.
  总被引:1,自引:0,他引:1  
An excess of 31 million m3/y of tertiary-treated wastewater is expected in Muscat, Oman, by 2015. This paper addresses the technical and cost estimation of managed aquifer recharge after reverse-osmosis treatment. The results indicate that the project is appealing from an economic perspective. The total cost varies between USD 0.353 and USD 0.550 per cubic metre, depending on the cost of electricity, the interest rate and the life span of the project. The project may face rejection from domestic users, who may be unwilling to accept mixing treated wastewater with the current water supply due to health risks. An alternative to indirect potable reuse is the installation of a separate network to service industrial users.  相似文献   
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