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21.
22.
Wu Li Yann-Hang Lee Wei-Tek Tsai Jingjing Xu Young-Sung Son Jun-Hee Park Kyung-Duk Moon 《Service Oriented Computing and Applications》2012,6(1):65-79
A smart home usually has a variety of devices or home appliance, instead of designing software for a specific home, this paper
proposes a service-oriented framework with a set of ontology systems to support service and device publishing, discovery of
devices and their services, composition of control software using existing control services that wrap devices, deployment,
and execution of the composed service in an computing environment, monitoring the execution, and recovery from device failure.
The ontology systems specify semantic information about devices, services, and workflows used in various smart home, and users
can compose and recompose services for their specific needs. New devices, workflows, and services can be added into ontology.
Most of the steps in this process can be automated including code generation. For example, service composition will be carried
out in three steps: abstract workflow design, function construction, and device discovery, and different codes can be generated
for different computing platforms such as Java and Open Services Gateway initiative environments. In this way, a variety of
smart home can be constructed rapidly using the framework by discovery and composition using existing services and workflows.
This paper illustrates this framework using a media control example to illustrate the ontology, discovery, composition, deployment,
execution, monitoring, and recovery. 相似文献
23.
Due to the explosive increases of data from both the cyber and physical worlds, the demand for database support in embedded systems is increasing. Databases for embedded systems, or embedded databases, are expected to provide timely in situ data services under various resource constraints, such as limited energy. However, traditional buffer cache management schemes, in which the primary goal is to minimize the number of I/O operations, is problematic since they do not consider the constraints of modern embedded devices such as limited energy and distinctive underlying storage. In particular, due to asymmetric read/write characteristics of flash memory-based storage of modern embedded devices, minimum buffer cache misses neither coincide with minimum power consumption nor minimum I/O deadline misses. In this paper we propose a novel power- and time-aware buffer cache management scheme for embedded databases. A novel multi-dimensional feedback control architecture is proposed and the characteristics of underlying storage of modern embedded devices is exploited for the simultaneous support of the desired I/O power consumption and the I/O deadline miss ratio. We have shown through an extensive simulation that our approach satisfies both power and timing requirements in I/O operations under a variety of workloads while consuming significantly smaller buffer space than baseline approaches. 相似文献
24.
Myeongjoo Son Seyeon Oh Junwon Choi Ji Tae Jang Kuk Hui Son Kyunghee Byun 《International journal of molecular sciences》2021,22(8)
Hypertension induces renal fibrosis or tubular interstitial fibrosis, which eventually results in end-stage renal disease. Epithelial-to-mesenchymal transition (EMT) is one of the underlying mechanisms of renal fibrosis. Though previous studies showed that Ecklonia cava extracts (ECE) and dieckol (DK) had inhibitory action on angiotensin (Ang) I-converting enzyme, which converts Ang I to Ang II. It is known that Ang II is involved in renal fibrosis; however, it was not evaluated whether ECE or DK attenuated hypertensive nephropathy by decreasing EMT. In this study, the effect of ECE and DK on decreasing Ang II and its down signal pathway of angiotensin type 1 receptor (AT1R)/TGFβ/SMAD, which is related with the EMT and restoring renal function in spontaneously hypertensive rats (SHRs), was investigated. Either ECE or DK significantly decreased the serum level of Ang II in the SHRs. Moreover, the renal expression of AT1R/TGFβ/SMAD was decreased by the administration of either ECE or DK. The mesenchymal cell markers in the kidney of SHRs was significantly decreased by ECE or DK. The fibrotic tissue of the kidney of SHRs was also significantly decreased by ECE or DK. The ratio of urine albumin/creatinine of SHRs was significantly decreased by ECE or DK. Overall, the results of this study indicate that ECE and DK decreased the serum levels of Ang II and expression of AT1R/TGFβ/SMAD, and then decreased the EMT and renal fibrosis in SHRs. Furthermore, the decrease in EMT and renal fibrosis could lead to the restoration of renal function. It seems that ECE or DK could be beneficial for decreasing hypertensive nephropathy by decreasing EMT and renal fibrosis. 相似文献
25.
Thi Kieu Oanh Nguyen Thi Luong Vu Minh Quan Nguyen Huynh Kim Khanh Ta Kyoung Sun Park Soo Hyeon Kim Chong Jai Kim Yeon Jin Jang Han Choe 《International journal of molecular sciences》2021,22(10)
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a member of the colony-stimulating factor (CSF) family, which functions to enhance the proliferation and differentiation of hematopoietic stem cells and other hematopoietic lineages such as neutrophils, dendritic cells, or macrophages. These proteins have thus generated considerable interest in clinical therapy research. A current obstacle to the prokaryotic production of human GM-CSF (hGM-CSF) is its low solubility when overexpressed and subsequent complex refolding processes. In our present study, the solubility of hGM-CSF was examined when combined with three N-terminal fusion tags in five E. coli strains at three different expression temperatures. In the five E. coli strains BL21 (DE3), ClearColi BL21 (DE3), LOBSTR, SHuffle T7 and Origami2 (DE3), the hexahistidine-tagged hGM-CSF showed the best expression but was insoluble in all cases at each examined temperature. Tagging with the maltose-binding protein (MBP) and the b′a′ domain of protein disulfide isomerase (PDIb′a′) greatly improved the soluble overexpression of hGM-CSF at 30 °C and 18 °C. The solubility was not improved using the Origami2 (DE3) and SHuffle T7 strains that have been engineered for disulfide bond formation. Two conventional chromatographic steps were used to purify hGM-CSF from the overexpressed PDIb′a′-hGM-CSF produced in ClearColi BL21 (DE3). In the experiment, 0.65 mg of hGM-CSF was isolated from a 0.5 L flask culture of these E. coli and showed a 98% purity by SDS-PAGE analysis and silver staining. The bioactivity of this purified hGM-CSF was measured at an EC50 of 16.4 ± 2 pM by a CCK8 assay in TF-1 human erythroleukemia cells. 相似文献
26.
Chi Nguyen Quynh Ho Minh Thi Tran Chung Chinh Doan Son Nghia Hoang Diem Hong Tran Long Thanh Le 《International journal of molecular sciences》2021,22(9)
Simulated microgravity (SMG) induced the changes in cell proliferation and cytoskeleton organization, which plays an important factor in various cellular processes. The inhibition in cell cycle progression has been considered to be one of the main causes of proliferation inhibition in cells under SMG, but their mechanisms are still not fully understood. This study aimed to evaluate the effects of SMG on the proliferative ability and cytoskeleton changes of Chang Liver Cells (CCL-13). CCL-13 cells were induced SMG by 3D clinostat for 72 h, while the control group were treated in normal gravity at the same time. The results showed that SMG reduced CCL-13 cell proliferation by an increase in the number of CCL-13 cells in G0/G1 phase. This cell cycle phase arrest of CCL-13 cells was due to a downregulation of cell cycle-related proteins, such as cyclin A1 and A2, cyclin D1, and cyclin-dependent kinase 6 (Cdk6). SMG-exposed CCL-13 cells also exhibited a downregulation of α-tubulin 3 and β-actin which induced the cytoskeleton reorganization. These results suggested that the inhibited proliferation of SMG-exposed CCL-13 cells could be associate with the attenuation of major cell cycle regulators and main cytoskeletal proteins. 相似文献
28.
介绍了国外超细纤维人工皮革的产销与应用情况.追溯了国际上这一领域最新技术的进展.通过对国内未来几年市场需求的分析与预测,提出了应在高起点上发展我国人工皮革的思路。 相似文献
29.
Oligomerization of glycine (gly) and diglycine (gly2) on montmorillonite was performed as cyclic, drying-wetting process at temperatures below 100°C, under varying reaction conditions. The influence of substrate/clay ratio, temperature and pH was found to be different for amino acid (AA) dimerization, cyclic anhydride (CA) formation and peptide chain elongation. High temperatures and neutral pH favour CA formation over diglycine production. An AA/catalyst ratio of 0.2 mmol/g leads to optimal yields. This supports the assumption that amino acid dimerization and CA formation take place at the edges of clay particles. Peptide chain elongation, starting from gly2, produces higher yields at higher temperatures and neutral pH. 相似文献
30.
Novel polypyrrole (PPy)/polydimethylsiloxane (PDMS) composite membrane was prepared by interfacial polymerization to make a very effective gas separation membrane. We found that Polymerized PPy films as thin as ~200 nm could be chemically synthesized as freestanding membranes by using the interfacial polymerization technique. Additionally, we show that difference morphology of PPys films was obtained by controlling polymerization rate and more dense films were formed at low polymerization rate. Wide X-ray diffraction study showed the d spacing value of the PPy film decreased from 4.89 å to 3.67 å by the rate of polymerization decreases. According to d spacing value decrease, selectivity of a PPy composite membrane was increased dramatically and permeability was reduced gradually. This high selectivity was derived from d spacing closed to the kinetic diameter of nitrogen. These results indicated that the permeability is controlled by the diffusion coefficient, reflecting the packed structure of the PPy film. The highest selectivity value of composite membrane that was prepared by interfacial polymerization was O2/N2=17.2 and permeability for O2 was 40.2 barrer. 相似文献