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71.
Fabio Ancona Stefano Rovetta Rodolfo Zunino 《Engineering Applications of Artificial Intelligence》1997,10(6):573-580
The paper describes a parallel implementation of a neural algorithm performing vector quantization for very low bit-rate video compression on toroidal-mesh multiprocessor systems. The neural model considered is a plastic version of the Neural Gas algorithm, whose features are suitable for implementations on toroidal mesh topologies. The architecture adopted, and the data-allocation strategy, enhance the method's scaling properties and remarkable efficiency. The parallel approach is supported by a theoretical analysis of the efficiency of the overall structure. Experimental results on a significant testbed and the fit between predicted and measured values confirm the validity of the parallel approach. 相似文献
72.
Berretti Stefano Del Bimbo Alberto Pala Pietro 《Multimedia Tools and Applications》2004,24(3):215-232
Searching information through the Internet often requires users to separately contact several digital libraries, use each library interface to author the query, analyze retrieval results and merge them with results returned by other libraries. Such a solution could be simplified by using a centralized server that acts as a gateway between the user and several distributed repositories: The centralized server receives the user query, forwards the user query to federated repositories—possibly translating the query in the specific format required by each repository—and fuses retrieved documents for presentation to the user. To accomplish these tasks efficiently, the centralized server should perform some major operations such as: resource selection, query transformation and data fusion.
In this paper we report on some aspects of MIND, a system for managing distributed, heterogeneous multimedia libraries (MIND, 2001, http://www.mind-project.org). In particular, this paper focusses on the issue of fusing results returned by different image repositories. The proposed approach is based on normalization of matching scores assigned to retrieved images by individual libraries. Experimental results on a prototype system show the potential of the proposed approach with respect to traditional solutions. 相似文献
73.
Veronica Conti Claudio Cantini Marco Romi Maria Michela Cesare Luigi Parrotta Stefano Del Duca Giampiero Cai 《International journal of molecular sciences》2022,23(10)
Future climate scenarios suggest that crop plants will experience environmental changes capable of affecting their productivity. Among the most harmful environmental stresses is drought, defined as a total or partial lack of water availability. It is essential to study and understand both the damage caused by drought on crop plants and the mechanisms implemented to tolerate the stress. In this study, we focused on four cultivars of tomato, an economically important crop in the Mediterranean basin. We investigated the biochemical mechanisms of plant defense against drought by focusing on proteins specifically involved in this stress, such as osmotin, dehydrin, and aquaporin, and on proteins involved in the general stress response, such as HSP70 and cyclophilins. Since sugars are also known to act as osmoprotectants in plant cells, proteins involved in sugar metabolism (such as RuBisCO and sucrose synthase) were also analyzed. The results show crucial differences in biochemical behavior among the selected cultivars and highlight that the most tolerant tomato cultivars adopt quite specific biochemical strategies such as different accumulations of aquaporins and osmotins. The data set also suggests that RuBisCO isoforms and aquaporins can be used as markers of tolerance/susceptibility to drought stress and be used to select tomato cultivars within breeding programs. 相似文献
74.
Margherita Passariello Veronica Ferrucci Emanuele Sasso Lorenzo Manna Rosa Rapuano Lembo Stefano Pascarella Giovanna Fusco Nicola Zambrano Massimo Zollo Claudia De Lorenzo 《International journal of molecular sciences》2022,23(10)
The dramatic experience with SARS-CoV-2 has alerted the scientific community to be ready to face new epidemics/pandemics caused by new variants. Among the therapies against the pandemic SARS-CoV-2 virus, monoclonal Antibodies (mAbs) targeting the Spike glycoprotein have represented good drugs to interfere in the Spike/ Angiotensin Converting Enzyme-2 (ACE-2) interaction, preventing virus cell entry and subsequent infection, especially in patients with a defective immune system. We obtained, by an innovative phage display selection strategy, specific binders recognizing different epitopes of Spike. The novel human antibodies specifically bind to Spike-Receptor Binding Domain (RBD) in a nanomolar range and interfere in the interaction of Spike with the ACE-2 receptor. We report here that one of these mAbs, named D3, shows neutralizing activity for virus infection in cell cultures by different SARS-CoV-2 variants and retains the ability to recognize the Omicron-derived recombinant RBD differently from the antibodies Casirivimab or Imdevimab. Since anti-Spike mAbs, used individually, might be unable to block the virus cell entry especially in the case of resistant variants, we investigated the possibility to combine D3 with the antibody in clinical use Sotrovimab, and we found that they recognize distinct epitopes and show additive inhibitory effects on the interaction of Omicron-RBD with ACE-2 receptor. Thus, we propose to exploit these mAbs in combinatorial treatments to enhance their potential for both diagnostic and therapeutic applications in the current and future pandemic waves of coronavirus. 相似文献
75.
This paper offers a comprehensive overview on the role of nanostructures in the development of advanced anode materials for application in both lithium and sodium-ion batteries. In particular, this review highlights the differences between the two chemistries, the critical effect of nanosize on the electrode performance, as well as the routes to exploit the inherent potential of nanostructures to achieve high specific energy at the anode, enhance the rate capability, and obtain a long cycle life. Furthermore, it gives an overview of nanostructured sodium- and lithium-based anode materials, and presents a critical analysis of the advantages and issues associated with the use of nanotechnology. 相似文献
76.
Giacomo Lazzarino Valentina Di Pietro Marco Rinaudo Zsuzsanna Nagy Nicholas M. Barnes Lars Bruce Stefano Signoretti Renata Mangione Miriam Wissam Saab Barbara Tavazzi Antonio Belli Giuseppe Lazzarino Angela Maria Amorini Ann Logan 《International journal of molecular sciences》2022,23(15)
In a previous study, we found that administration of ILB®, a new low molecular weight dextran sulphate, significantly improved mitochondrial functions and energy metabolism, as well as decreased oxidative/nitrosative stress, of brain tissue of rats exposed to severe traumatic brain injury (sTBI), induced by the closed-head weight-drop model of diffused TBI. Using aliquots of deproteinized brain tissue of the same animals of this former study, we here determined the concentrations of 24 amino acids of control rats, untreated sTBI rats (sacrificed at 2 and 7 days post-injury) and sTBI rats receiving a subcutaneous ILB® administration (at the dose levels of 1, 5 and 15 mg/kg b.w.) 30 min post-impact (sacrificed at 2 and 7 days post-injury). Additionally, in a different set of experiments, new groups of control rats, untreated sTBI rats and ILB®-treated rats (administered 30 min after sTBI at the dose levels of 1 or 5 mg/kg b.w.) were studied for their neurocognitive functions (anxiety, locomotor capacities, short- and long-term memory) at 7 days after the induction of sTBI. Compared to untreated sTBI animals, ILB® significantly decreased whole brain glutamate (normalizing the glutamate/glutamine ratio), glycine, serine and γ-aminobutyric acid. Furthermore, ILB® administration restored arginine metabolism (preventing nitrosative stress), levels of amino acids involved in methylation reactions (methionine, L-cystathionine, S-adenosylhomocysteine), and N-acetylaspartate homeostasis. The macroscopic evidences of the beneficial effects on brain metabolism induced by ILB® were the relevant improvement in neurocognitive functions of the group of animals treated with ILB® 5 mg/kg b.w., compared to the marked cognitive decline measured in untreated sTBI animals. These results demonstrate that ILB® administration 30 min after sTBI prevents glutamate excitotoxicity and normalizes levels of amino acids involved in crucial brain metabolic functions. The ameliorations of amino acid metabolism, mitochondrial functions and energy metabolism in ILB®-treated rats exposed to sTBI produced significant improvement in neurocognitive functions, reinforcing the concept that ILB® is a new effective therapeutic tool for the treatment of sTBI, worth being tested in the clinical setting. 相似文献
77.
Elisa Boschetti Leonardo Caporali Roberto DAngelo Carolina Malagelada Anna Accarino Maria Teresa Dotti Roberta Costa Giovanna Cenacchi Loris Pironi Rita Rinaldi Vincenzo Stanghellini Stefano Ratti Lucia Manzoli Valerio Carelli Roberto De Giorgio 《International journal of molecular sciences》2022,23(15)
mitochondrial neuro-gastrointestinal encephalomyopathy (MNGIE) is a rare genetic disorder characterized by thymidine phosphorylase (TP) enzyme defect. The absence of TP activity induces the imbalance of mitochondrial nucleotide pool, leading to impaired mitochondrial DNA (mtDNA) replication and depletion. Since mtDNA is required to ensure oxidative phosphorylation, metabolically active tissues may not achieve sufficient energy production. The only effective life-saving approach in MNGIE has been the permanent replacement of TP via allogeneic hematopoietic stem cell or liver transplantation. However, the follow-up of transplanted patients showed that gut tissue changes do not revert and fatal complications, such as massive gastrointestinal bleeding, can occur. The purpose of this study was to clarify whether the reintroduction of TP after transplant can recover mtDNA copy number in a normal range. Using laser capture microdissection and droplet-digital-PCR, we assessed the mtDNA copy number in each layer of full-thickness ileal samples of a naive MNGIE cohort vs. controls and in a patient pre- and post-TP replacement. The treatment led to a significant recovery of gut tissue mtDNA amount, thus showing its efficacy. Our results indicate that a timely TP replacement is needed to maximize therapeutic success before irreversible degenerative tissue changes occur in MNGIE. 相似文献
78.
AdaBoost is one of the most popular classification methods. In contrast to other ensemble methods (e.g., Bagging) the AdaBoost is inherently sequential. In many data intensive real-world situations this may limit the practical applicability of the method. P-AdaBoost is a novel scheme for the parallelization of AdaBoost, which builds upon earlier results concerning the dynamics of AdaBoost weights. P-AdaBoost yields approximations to the standard AdaBoost models that can be easily and efficiently distributed over a network of computing nodes. Properties of P-AdaBoost as a stochastic minimizer of the AdaBoost cost functional are discussed. Experiments are reported on both synthetic and benchmark data sets. 相似文献
79.
We describe the organization of a general purpose data archival system for Write-Once, Read-Many (WORM) optical disks. The system has been designed for large-scale and long-term data storage and retrieval. The archival system is independent of the operating system, flat, self-consistent, does not use any write cache on magnetic disk, and allows the exploitation of auxiliary information on magnetic disk, which can be rebuilt immediately in case of a crash, to speed up file retrieval. A library in C language, called pODLIB, has been implemented as a portable interface to the archival system. 相似文献
80.