A Novel Morphological Parameter Predicting Fibrotic Evolution in Myeloproliferative Neoplasms: New Evidence and Molecular Insights

Philadelphia-negative chronic myeloproliferative neoplasms (MPNs) represent a group of hematological disorders that are traditionally considered as indistinct slow progressing conditions; still, a subset of cases shows a rapid evolution towards myelofibrotic bone marrow failure. Specific abnormalities in the megakaryocyte lineage seem to play a central role in this evolution, especially in the bone marrow fibrosis but also in the induction of myeloproliferation. In this review, we analyze the current knowledge of prognostic factors of MPNs related to their evolution to myelofibrotic bone marrow failure. Moreover, we focused the role of the megakaryocytic lineage in the various stages of MPNs, with updated examples of MPNs in vitro and in vivo models and new therapeutic implications.     

The Potentiality of Plant-Derived Nanovesicles in Human Health—A Comparison with Human Exosomes and Artificial Nanoparticles

Research in science and medicine is witnessing a massive increases in literature concerning extracellular vesicles (EVs). From a morphological point of view, EVs include extracellular vesicles of a micro and nano sizes. However, this simplistic classification does not consider both the source of EVs, including the cells and the species from which Evs are obtained, and the microenvironmental condition during EV production. These two factors are of crucial importance for the potential use of Evs as therapeutic agents. In fact, the choice of the most suitable Evs for drug delivery remains an open debate, inasmuch as the use of Evs of human origin may have at least two major problems: (i) autologous Evs from a patient may deliver dangerous molecules; and (ii) the production of EVs is also limited to cell factory conditions for large-scale industrial use. Recent literature, while limited to only a few papers, when compared to the papers on the use of human EVs, suggests that plant-derived nanovesicles (PDNV) may represent a valuable tool for extensive use in health care.     

The Role of NLRP3 Inflammasome Activation and Oxidative Stress in Varicocele-Mediated Male Hypofertility

Varicocele (VC) is the most common abnormality identified in men evaluated for hypofertility. Increased levels of reactive oxygen species (ROS) and reduced antioxidants concentrations are key contributors in varicocele-mediated hypofertility. Moreover, inflammation and alterations in testicular immunity negatively impact male fertility. In particular, NLRP3 inflammasome activation was hypothesized to lead to seminal inflammation, in which the levels of specific cytokines, such as IL-1β and IL-18, are overexpressed. In this review, we described the role played by oxidative stress (OS), inflammation, and NLRP3 inflammasome activation in VC disease. The consequences of ROS overproduction in testis, including inflammation, lipid peroxidation, mitochondrial dysfunction, chromatin damage, and sperm DNA fragmentation, leading to abnormal testicular function and failed spermatogenesis, were highlighted. Finally, we described some therapeutic antioxidant strategies, with recognized beneficial effects in counteracting OS and inflammation in testes, as possible therapeutic drugs against varicocele-mediated hypofertility.     

Primary Aldosteronism and Resistant Hypertension: A Pathophysiological Insight

Primary aldosteronism (PA) is a pathological condition characterized by an excessive aldosterone secretion; once thought to be rare, PA is now recognized as the most common cause of secondary hypertension. Its prevalence increases with the severity of hypertension, reaching up to 29.1% in patients with resistant hypertension (RH). Both PA and RH are “high-risk phenotypes”, associated with increased cardiovascular morbidity and mortality compared to non-PA and non-RH patients. Aldosterone excess, as occurs in PA, can contribute to the development of a RH phenotype through several mechanisms. First, inappropriate aldosterone levels with respect to the hydro-electrolytic status of the individual can cause salt retention and volume expansion by inducing sodium and water reabsorption in the kidney. Moreover, a growing body of evidence has highlighted the detrimental consequences of “non-classical” effects of aldosterone in several target tissues. Aldosterone-induced vascular remodeling, sympathetic overactivity, insulin resistance, and adipose tissue dysfunction can further contribute to the worsening of arterial hypertension and to the development of drug-resistance. In addition, the pro-oxidative, pro-fibrotic, and pro-inflammatory effects of aldosterone may aggravate end-organ damage, thereby perpetuating a vicious cycle that eventually leads to a more severe hypertensive phenotype. Finally, neither the pathophysiological mechanisms mediating aldosterone-driven blood pressure rise, nor those mediating aldosterone-driven end-organ damage, are specifically blocked by standard first-line anti-hypertensive drugs, which might further account for the drug-resistant phenotype that frequently characterizes PA patients.     

Energy-aware lazy scheduling algorithm for energy-harvesting sensor nodes

The main problem in dealing with energy-harvesting (EH) sensor nodes is represented by the scarcity and non-stationarity of powering, due to the nature of the renewable energy sources. In this work, the authors address the problem of task scheduling in processors located in sensor nodes powered by EH sources. Some interesting solutions have appeared in the literature in the recent past, as the lazy scheduling algorithm (LSA), which represents a performing mix of scheduling effectiveness and ease of implementation. With the aim of achieving a more efficient and conservative management of energy resources, a new improved LSA solution is here proposed. Indeed, the automatic ability of foreseeing at run-time the task energy starving (i.e. the impossibility of finalizing a task due to the lack of power) is integrated within the original LSA approach. Moreover, some modifications have been applied in order to reduce the LSA computational complexity and thus maximizing the amount of energy available for task execution. The resulting technique, namely energy-aware LSA, has then been tested in comparison with the original one, and a relevant performance improvement has been registered both in terms of number of executable tasks and in terms of required computational burden.     

Making a mesh router/gateway from a smartphone: Is that a practical solution?

This paper aims at answering the question whether it is practical to build a mesh-phone or not. A mesh-phone is a smartphone acting as a mesh router, i.e. either actively participating in the process of packet forwarding towards a mesh gateway, or acting itself as a gateway toward the Internet. Technical aspects of the mesh-phone implementation, such as design constraints and implementation details, are addressed. The technical feasibility is validated by describing the implementation of a prototype of the mesh-enabled phone over the Openmoko^TM open platform. Besides technical feasibility also convenience of the addressed solution is analyzed in terms of the consumed power, and some “energy-saving” related enhancements are suggested to be applied to future user’s devices.     

Sensitivity analysis for reliable design verification of nuclear turbosets

In this paper, we present an application of sensitivity analysis for design verification of nuclear turbosets. Before the acquisition of a turbogenerator, energy power operators perform independent design assessment in order to assure safe operating conditions of the new machine in its environment. Variables of interest are related to the vibration behaviour of the machine: its eigenfrequencies and dynamic sensitivity to unbalance. In the framework of design verification, epistemic uncertainties are preponderant. This lack of knowledge is due to inexistent or imprecise information about the design as well as to interaction of the rotating machinery with supporting and sub-structures. Sensitivity analysis enables the analyst to rank sources of uncertainty with respect to their importance and, possibly, to screen out insignificant sources of uncertainty. Further studies, if necessary, can then focus on predominant parameters. In particular, the constructor can be asked for detailed information only about the most significant parameters.     

Game theory and time utility functions for a radio aware scheduling algorithm for WiMAX networks

In WiMAX systems the Base Station scheduler plays a key role as it controls the sharing of the radio resources among the users. The goal of the scheduler is multiple: achieve fair usage of the resources, satisfy the QoS requirements of the users, maximize goodput, and minimize power consumption, and at the same time ensuring feasible algorithm complexity and system scalability. Since most of these goals are contrasting, scheduler designers usually focus their attention on optimizing one aspect only. In this scenario, we propose a scheduling algorithm (called GTS_Nmathrm{GTS_N}) whose goal is to contemporaneously achieve efficiency and fairness, while also taking into account the QoS requirements and the channel state. GTS_Nmathrm{GTS_N} exploits the properties of Time Utility Functions (TUFs) and Game Theory. Simulations prove that the performance of GTS_N,mathrm{GTS_N}, when compared to that of several well-known schedulers, is remarkable. GTS_Nmathrm{GTS_N} provides the best compromise between the two contrasting objectives of fairness and efficiency, while QoS requirements are in most cases guaranteed. However, the exponential complexity introduced by the game theory technique makes it rather impractical and not computationally scalable for a large number of users. Thus we developed a suboptimal version, named sub-GTS_N.mathrm{GTS_N}. We show that this version retains most of the features and performance figures of its brother, but its complexity is linear with the number of users.     

Planar mirrors for image-based robot localization and 3-D reconstruction

Planar catadioptric vision sensors consist of a pinhole camera observing a scene being reflected on two (or more) planar mirrors. These systems have recently received an increasing attention because, unlike stereo cameras, can capture two views of the same scene without the need of hardware multi-camera synchronization and calibration. In this paper we explore the original scenario in which a robot manipulator, equipped with a pinhole camera on its end-effector, observes an unknown 3-D scene both directly and reflected through multiple mirrors. We present new multiple-view properties for this scenario and, based on these theoretical results, we present new image-based camera localization and new 3-D scene reconstruction algorithms. Extensive simulation and real-data experiments illustrate the theory and show the effectiveness of the proposed designs.     

使简单欧姆计具备千兆欧量程的积分器

德州仪器公司(TI)的IVC102精密积分器有高质量的内部电容.图1的电路可以用来测量非常高的Rx电阻值.一只精密差分放大器(TI的INA105)为Rx施加一个基准电压.积分期间,在IVC12的输出端产生一个负电压斜坡Vo.两只LM311将Vo的振幅与两个固定阈值作比较,产生两个数字信号:开始和停止.