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61.
Periklis Dousdampanis Stelios F. Assimakopoulos Ioulia Syrocosta Ioannis Ntouvas Kostas Gkouias Konstantina Trigka 《Hemodialysis international. International Symposium on Home Hemodialysis》2020,24(3):E37-E39
We present a male diabetic type 2 patient on hemodialysis (HD) with high cardiovascular (CVD) risk and hyperlipidemia. The patient was under cholesterol‐lowering therapy with statin and ezetimibe but he was obligated to discontinue due to chronic hepatitis C virus infection. Statins and ezetimibe may exert a potential hepatotoxic effect and for this reason, we attempted to find an alternative treatment to prevent CVD. Given that a potential hepatotoxic effect has not been reported for Abs SPCK9, we administered alirocumab 150 mg every 2 weeks for a total of 8 weeks. Low‐density lipoprotein levels have decreased and no side effects have been observed. In conclusion, alirocumab is a safe and efficient alternative therapy approach for HD patients with high CVD risk and liver abnormalities. We suggest that SPCK 9 inhibitors should be considered as a first line treatment for lowering cholesterol in this specific patient group. 相似文献
62.
This paper presents a novel skeleton pruning approach based on angle maps. The angle map of the test object is a representation of the object contour’s angles during a 2D empirical mode like decomposition (EMD-like). The intrinsic mode functions produced by the EMD like decomposition are used to compose the angle map of the object contour. This angle map has very good properties for obtaining the object’s skeleton. The experimental results demonstrate that the obtained skeletons match to hand-labelled skeletons provided by human subjects, even in the presence of significant noise and shape variations, cuts and tears, and have the same topology as the original skeletons. 相似文献
63.
Theologos Athanaselis Stelios Bakamidis Ioannis Dologlou Evmorfia N. Argyriou Antonis Symvonis 《Multimedia Tools and Applications》2014,68(3):681-699
This work presents our effort to incorporate a state of the art speech recognition engine into a new platform for assistive reading for improving reading ability of Greek dyslexic students. This platform was developed in the framework of the Agent-DYSL, IST project, and facilitates dyslexic children in learning to read fluently. Unlike previously presented approaches, the aim of the system is not only to enable access to the reading materials within an inclusive learning system but to promote the development of reading skills by adjusting and adapting in the light of feedback to the system. The idea is to improve speech recognition performance so that gradually increase the reading capabilities of the user, gradually diminish the assistance provided, till he is able to read as a non-dyslexic reader. The evaluation results show that both learners’ reading pace and learners’ reading accuracy were increased. 相似文献
64.
Shaoyi Chen Stelios Florinas Abigail Teitgen Ze-Qi Xu Changshou Gao Herren Wu 《Science and Technology of Advanced Materials》2013,14(1):666-680
AbstractAntibodies and antigen-binding fragments (Fabs) can be used to modify the surface of nanoparticles for enhanced target binding. In our previous work, site-specific conjugation of Fabs to polymeric micelles using conventional methods was limited to approximately 30% efficiency, possibly due to steric hindrance related to macromolecular reactants. Here, we report a new method that enables conjugation of Fabs onto a micelle surface in a controlled manner with up to quantitative conversion of nanoparticle reactive groups. Variation of (i) PEG spacer length in a heterofunctionalized cross-linker and (ii) Fab/polymer feed ratios resulted in production of nanoparticles with a range of Fab densities on the surface up to the theoretical maximum value. The biological impact of variable Fab density was evaluated in vitro with respect to cell uptake and cytotoxicity of a drug-loaded (SN38) targeted polymeric micelle bearing anti-EphA2 Fabs. Fab conjugation increased cell uptake and potency compared with non-targeted micelles, although a Fab density of 60% resulted in decreased uptake and potency of the targeted micelles. Altogether, our findings demonstrate that conjugation strategies can be optimized to allow control of Fab density on the surface of nanoparticles and also that Fab density may need to be optimized for a given cell-surface target to achieve the highest bioactivity. 相似文献
65.
Rate-controlled constrained equilibrium provides a sound framework for deriving and testing low-dimensional models of combustion chemistry, yet its application so far has been limited. The purpose of this paper is twofold: to propose a formulation of RCCE as a differential-algebraic problem and show how existing formulations such as the constraint potentials can be derived from it, and to demonstrate how combustion problems involving flow, such as nonpremixed laminar flames, can be solved with RCCE. A 9-constraint set is employed to reduce a 63-species detailed mechanism for CH4-air combustion and is found to be sufficient for fairly accurate predictions of both ignition in a homogeneous reactor and the structure of nonpremixed laminar flames for a variety of strain rates, while the main features of the latter can also be reproduced with a 7-constraint subset. 相似文献
66.
67.
Effects of pressure on the formation of HCN and NH3 during the pyrolysis and gasification of Loy Yang brown coal in steam were investigated using a pressurised drop-tube/fixed-bed reactor. The NH3 yield increased with increasing pressure during both pyrolysis and gasification. Increasing pressure selectively favours the formation of NH3 at the expenses of other N-containing species. The changes in the yield of NH3 with increasing pressure were mainly observed in the feeding periods both during pyrolysis and gasification and were closely related to the formation and subsequent cracking of soot both as a result of intensified thermal cracking of volatile precursors inside the particles and as a result of volatile-char interactions after the release of volatiles. While the corresponding HCN yield during pyrolysis showed little sensitivity to changes in pressure, the HCN yield during gasification in steam showed some increases with increasing pressure. Our data indicate that the direct hydrogenation of char-N by H radicals, favoured by the presence of steam, is the main route of NH3 formation during pyrolysis and gasification. The direct conversion, either through hydrogenation or hydrolysis, of HCN into NH3 on char surface during the pyrolysis and gasification of brown coal is not an important route of NH3 formation. 相似文献
68.
Claudia N. Hoth Roland Steim Pavel Schilinsky Stelios A. Choulis Sandro F. Tedde Oliver Hayden Christoph J. Brabec 《Organic Electronics》2009,10(4):587-593
Herein we discuss the topographical and nanomorphological aspects of spray deposited organic photovoltaics. We show that the solvent properties have a massive impact on the topography, but less on the nanomorphology formation of composites based on the electron donor poly(3-hexylthiophene) (P3HT) and the electron acceptor [6,6]-phenyl C61 butyric acid methyl ester (PCBM). An adapted solvent mixture consisting of ortho-dichlorobenzene (oDCB) and 1,3,5-trimethylbenzene (mesitylene) allows us to demonstrate spray coated organic photovoltaic devices with 3.1% power conversion efficiency (PCE). Moreover, we show that spray coating is a feasible technology to deposit all solution processable layers of organic solar cells, including the hole transporting layer poly(3,4-ethylene dioxythiophene) doped with polystyrene sulphonic acid (PEDOT:PSS) as well and demonstrate fully spray coated devices with 2.7% PCE. 相似文献
69.
Kaminarides Stelios & Anifantakis Emmanuel 《International Journal of Food Science & Technology》2004,39(3):319-324
Rheological, physico‐chemical and organoleptic studies were made on five types of yoghurt originally from pure caprine milks of an Alpine breed and local breeds, pure ovine milk of the Lacaune breed, and two mixtures containing 50% caprine milk from an Alpine breed + 50% ovine milk of the Lacaune breed and 70% caprine milk of local breeds + 30% ovine milk of the Lacaune breed. Comparison of the yoghurts showed that it was possible to produce yoghurt of good quality from the last four types of milk. In contrast, pure caprine milk from an Alpine breed was not suitable for the production of yoghurt as this milk is low in dry matter and the yoghurt that was produced had the lowest firmness and significantly inferior organoleptic characteristics. Yoghurts prepared from mixtures of 50% caprine milk of an Alpine breed + 50% ovine milk of the Lacaune breed, and 70% caprine milk of local breeds + 30% ovine milk of the Lacaune breed, were of good quality, with similar consistency, rheological and organoleptic characteristics. 相似文献
70.
Aristides Bakandritsos George Mattheolabakis George Chatzikyriakos Tamas Szabo Vasilis Tzitzios Dimitris Kouzoudis Stelios Couris Konstantinos Avgoustakis 《Advanced functional materials》2011,21(8):1465-1475
Magnetic drug nanocarriers are synthesized following an arrested mineralization of magnetic spinel iron oxides in the presence of the biopolymer of sodium carboxymethylcellulose. Based on the experimental results, the polyelectrolyte corona probably attains a brushlike configuration around the magnetic particles. The inner core of these colloids may be constituted of polymer‐associated nanocrystallites, forming nanogel colloids. The hybrid colloids are endowed with a high loading capacity for the anticancer agent doxorubicin and pronounced pH responsiveness. They also display a dramatic increase in non‐linear optical response as compared to previous studies of similar materials. Furthermore, as cell studies indicate, the blank nanocarriers are cytocompatible and the drug retains its activity after loading in the nanocarriers. 相似文献