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In service tensile and compressive stresses occur in refractory linings, these stresses lead to creep of refractories. Ordinary refractories experience creep of the primary stage and may further proceed to the secondary and tertiary creep stage. For the development of advanced material models for finite element simulations it is necessary to investigate the creep behavior in all three creep stages under tensile and compressive loads. Hence, two advanced high temperature uniaxial creep testing devices, applying a wide range of tensile and compressive loads, were used to determine the three creep stages in a reasonable time under service related loading conditions. The Norton–Bailey creep equations and an inverse identification procedure were applied for the evaluation of the experimental results. A magnesia refractory was studied at elevated temperatures and its respective creep parameters for each stage were determined. The stress dependency on the creep behavior can be seen clearly on the creep curves and the corresponding creep parameters. Furthermore, a comparative study of creep parameters and creep rates was performed between the magnesia refractory and a magnesia-chromite refractory. The results demonstrate the significant asymmetrical creep behavior in tension and compression for both materials. The creep investigation in this paper favors the requirement for consideration of the three stage creep behavior and the asymmetrical creep behavior in thermomechanical modelling activities of industrial vessels.  相似文献   
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Spliceosome-mediated RNA trans-splicing has become an emergent tool for the repair of mutated pre-mRNAs in the treatment of genetic diseases. RNA trans-splicing molecules (RTMs) are designed to induce a specific trans-splicing reaction via a binding domain for a respective target pre-mRNA region. A previously established reporter-based screening system allows us to analyze the impact of various factors on the RTM trans-splicing efficiency in vitro. Using this system, we are further able to investigate the potential of antisense RNAs (AS RNAs), presuming to improve the trans-splicing efficiency of a selected RTM, specific for intron 102 of COL7A1. Mutations in the COL7A1 gene underlie the dystrophic subtype of the skin blistering disease epidermolysis bullosa (DEB). We have shown that co-transfections of the RTM and a selected AS RNA, interfering with competitive splicing elements on a COL7A1-minigene (COL7A1-MG), lead to a significant increase of the RNA trans-splicing efficiency. Thereby, accurate trans-splicing between the RTM and the COL7A1-MG is represented by the restoration of full-length green fluorescent protein GFP on mRNA and protein level. This mechanism can be crucial for the improvement of an RTM-mediated correction, especially in cases where a high trans-splicing efficiency is required.  相似文献   
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The growing popularity of Project Management Offices (PMOs) as organizational structures is grounded in the assumption they support more efficient and effective project management for better strategy implementation. However, research emphasizes they fail to deliver expected value: their unstable nature precludes the delivery of long-term benefits. This is compounded by the absence of a theory of PMO change and adaptation. Recent research, taking a co-evolution lens rooted in evolutionary theory, suggests that PMOs should be studied in relation to the broader organizational context, in order to better capture the dynamic interplay and fit between them. In this study, taking a routine perspective as micro-foundation and unit of analysis, we focus on the co-evolution between PMO and Project Portfolio Management (PfM) as organizational capability for six case studies. A structural analysis of the relational routines' system between PMO, PfM and the Organizational context allow us to unveil dynamics at stake, i.e. why and how changes occur, as well as eigen behaviors and the changing states of various routines elements (influential, mediating, dependent or not-influential). This study makes five contributions. We show that: 1) PMO and PfM can be conceptualized as collections of routines, 2) PMO and PfM co-evolve over time to adapt to organizational context influence, 3) the co-evolution of a routines' system, abstracted as a non-trivial machine, exhibits an eigen behavior, 4) applying a structural analysis approach allows to simulate the dynamics of a routines' system and to unveil the role of key routine elements and 5) eigen values of routines' systems allow to characterize their eigen behavior.  相似文献   
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Metallurgical and Materials Transactions A - The extent to which powder recycling can be permitted before risking a loss in performance of critical components is a major aspect for the viability of...  相似文献   
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As a result of river regulations over several centuries, followed by restoration measures in recent decades, most of the River Danube shoreline is man‐made, primarily riprap, but some reconstructed gravel banks and riparian side arms. We investigated the effects of these different structures on fish larval dispersal over a 20‐km stretch in Vienna via the use of drift nets. The habitats examined were created 18 years ago when the impoundment of the Danube hydropower station Vienna/Freudenau was constructed. About 15,000 fish larvae were trapped, and a subsample was determined to species level by DNA barcoding. In total, 26 different species were detected, including 10 species that are endangered or in danger of extinction. When species composition was considered, cyprinids become dominant at sites downstream of gravel bars, whereas in riprap sections, the majority of the larvae consist of invasive Gobiidae. Side arm habitats provide spawning and nursery grounds for additional species. Furthermore, clear species‐related seasonal patterns were observed with peak densities and multiple spawning periods of some species being recorded. The largest peak of Percidae occurred in the first half of May, followed by Cyprinidae at the end of May and Gobiidae in mid‐June.  相似文献   
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Several samples of exhaust diesel soot are investigated by inverse gas chromatography and linear solvation energy relationship (LSER) modelling according to their soluble organic fraction content and their time of exposure in oxidative conditions. The results demonstrate the evolution of the adsorptive properties of the studied materials towards volatile compounds during the oxidation under NO2.  相似文献   
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