Derivation of Path Independent Coupled Mix Mode Cohesive Laws from Fracture Resistance Curves

A generalised approach is presented to derive coupled mixed mode cohesive laws described with physical parameters such as peak traction, critical opening, fracture energy and cohesive shape. The approach is based on deriving mix mode fracture resistance curves from an effective mix mode cohesive law at different mode mixities. From the fracture resistance curves, the normal and shear stresses of the cohesive laws can be obtained by differentiation. Since, the mixed mode cohesive laws are obtained from a fracture resistance curve (potential function), path independence is automatically satisfied. The effective mix mode cohesive law can have different shape and cohesive law parameters at different mode mixities so that the approach can be applied to various material failure models.     

Design synthesis and structural optimization of a lightweight,monobloc cast iron brake disc with fingered hub

This article focuses on generating a monobloc fingered hub (top-hat) disc design, aiming at reducing disc mass but maintaining rotor thermal capacity, while also improving heat dissipation characteristics. The analyses and tests demonstrated that such a design is possible to achieve, with mass reduction of just over 9%. The activities included research into cast iron modelling, which gave very important insights into the limits of mechanical performance under bending. Initial finite element analyses enabled considerable progress to be made towards establishing a baseline design, but only through shape optimization and topology optimization procedures was the full potential of the design accomplished. Shape optimization facilitated the reduction of maximum principal stress by 32%, considerably improving disc torsional strength with practically no increase in mass. The safety factor in torsion achieved a value of 3.57. Topology optimization provided further, although small, mass reduction (1.5%) while maintaining low stress levels.     

Parallel Application Scheduling on Networks of Workstations

Parallel applications can be executed using the idle computing capacity of workstation clusters. However, it remains unclear how to schedule the processors among different applications most effectively. Processor scheduling algorithms that were successful for shared-memory machines have proven to be inadequate for distributed memory environments due to the high costs of remote memory accesses and redistributing data. We investigate how knowledge of system load and application characteristics can be used in scheduling decisions. We propose a new algorithm based on adaptive equipartitioning, which, by properly exploiting both the information types above, performs better than other nonpreemptive scheduling rules, and nearly as well as idealized versions of preemptive rules (with free preemption). We conclude that the new algorithm is suitable for use in scheduling parallel applications on networks of workstations.     

Chimeric Stimuli-Responsive Liposomes as Nanocarriers for the Delivery of the Anti-Glioma Agent TRAM-34

Nanocarriers are delivery platforms of drugs, peptides, nucleic acids and other therapeutic molecules that are indicated for severe human diseases. Gliomas are the most frequent type of brain tumor, with glioblastoma being the most common and malignant type. The current state of glioma treatment requires innovative approaches that will lead to efficient and safe therapies. Advanced nanosystems and stimuli-responsive materials are available and well-studied technologies that may contribute to this effort. The present study deals with the development of functional chimeric nanocarriers composed of a phospholipid and a diblock copolymer, for the incorporation, delivery and pH-responsive release of the antiglioma agent TRAM-34 inside glioblastoma cells. Nanocarrier analysis included light scattering, protein incubation and electron microscopy, and fluorescence anisotropy and thermal analysis techniques were also applied. Biological assays were carried out in order to evaluate the nanocarrier nanotoxicity in vitro and in vivo, as well as to evaluate antiglioma activity. The nanosystems were able to successfully manifest functional properties under pH conditions, and their biocompatibility and cellular internalization were also evident. The chimeric nanoplatforms presented herein have shown promise for biomedical applications so far and should be further studied in terms of their ability to deliver TRAM-34 and other therapeutic molecules to glioblastoma cells.     

On mixing rules for the hydraulic permeability of fiber mixtures

We perform numerical simulations of Stokes flow through ordered arrays of fibers of square cross-section. The results for the permeability of single-size-fiber arrays are in very good agreement with the well-known correlation of Jackson and James, provided that an effective radius of equivalent cylindrical fibers is used with the same cross-sectional area. Then, we consider arrays of mixtures of different-sized fibers and test several mixing rules, proposed for estimating the composite permeability. The two most well-known, namely, the unweighted- and the volume-averaged resistivity rules give good predictions for not too large size-ratios, yet they systematically overestimate and underestimate the numerical results, respectively. Then, it appears almost self-evident that a combination of the above two mixing rules would provide a better prediction. Indeed, the geometric mean gives excellent agreement with the numerical results over an extended range of size ratios and relative volume fractions.     

Adjectival and Adverbial Modification: The View from Modern Type Theories

In this paper we present a study of adjectival/adverbial modification using modern type theories (MTTs), i.e. type theories within the tradition of Martin-Löf. We present an account of various issues concerning adjectival/adverbial modification and argue that MTTs can be used as an adequate language for interpreting NL semantics. MTTs are not only expressive enough to deal with a range of modification phenomena, but are furthermore well-suited to perform reasoning tasks that can be easily implemented (e.g. in proof-assistants) given their proof-theoretic nature. In MTT-semantics, common nouns are interpreted as types rather than predicates. Therefore, in order to capture the semantics of adjectives adequately, one needs to meet the challenge of modeling CNs modified by adjectives as types. To explicate that this can be done successfully, we first look at the mainstream classification of adjectives, i.e. intersective, subsective and non-subsective adjectives. There, we show that the rich type structure available in MTTs, along with a suitable subtyping framework, offers an adequate mechanism to model these cases. In particular, this modelling naturally takes care of the characterising inferences associated with each class of adjectives. Then, more advanced issues on adjectival modification are discussed: (a) degree adjectives, (b) comparatives and (c) multidimensional adjectives. There, it is shown that the use of indexed types can be usefully applied in order to deal with these cases. In the same vein, the issue of adverbial modification is discussed. We study two general typings for sentence and VP adverbs respectively. It is shown that the rich type structure in MTTs further provides useful organisational mechanisms in giving formal semantics for adverbs. In particular, we discuss the use of \(\varSigma \)-types to capture the veridicality/non-veridicality distinction and further discuss cases of intensional adverbs using the type theoretic notion of context (i.e. without resorting to intensional typing). We also look at manner, subject and speech act adverbials and propose solutions using MTTs. Finally, we show that the current proof technology can help mechanically check the associated inferences. A number of our proposals concerning adjectival and adverbial modification have been formalised in the proof assistant Coq and many of the associated inference patterns are checked to be correctly captured.     

Relationship of toughness and modulus of elasticity in static bending of small clear spruce wood specimens

Unlike static bending, toughness is a mechanical property less commonly measured in clear wood. The paper presents results on the relationship of toughness and modulus of elasticity in static bending based on DIN standard tests on small, clear specimens of spruce, 2×2?cm² in cross section.     

Optical fiber long-period grating humidity sensor with poly(ethylene oxide)/cobalt chloride coating

A long-period fiber grating (LPFG) humidity sensor is reported utilizing poly(ethylene oxide)/cobalt chloride (PEO/CoCl2) as a hybrid hygrosensitive cladding coating. A thin overlay of the material is deposited on the LPFG and with exposure to different ambient humidity levels, its spectral properties are modified. The material parameters associated with the sensing mechanism may include those of refractive index, absorption, and morphological alterations of the overlaid material. Relative humidity variations in the range from 50% to 95% have been detected with a resolution better than 0.2%. The response time constant of the fiber sensor is of the order of a few hundred milliseconds.