On the simulation,economic analysis,and life cycle assessment of batch-mode organic solvent recovery alternatives for the pharmaceutical industry

This study explores design alternatives for the purification and possible reuse of low-volume organic solvents waste streams in pharmaceutical manufacturing. Solvent use has a large impact on the life cycle of pharmaceutical processes, as typically 80–90% of the total mass used in the production of an active pharmaceutical ingredient is attributed to solvent use. Solvents are not consumed in pharmaceutical processes so they exit the process as waste. These waste streams are usually disposed of using incineration; therefore, generating significant life cycle emissions from disposal and replacement of virgin solvent. Solvent recovery efforts are generally limited to large-volume waste streams. However, results show that solvents in low-volume streams can also be economically recovered using a versatile multi-campaign solvent recovery skid. Three different solvent waste streams were evaluated, and 85.3% reduction in total emissions and 86.3% reduction in operating costs were achieved. Investment in the solvent recovery system was determined to have a payback period of 4.5 years and a 28% IRR over 10 years. A life cycle impact assessment shows impacts on the human health, ecosystems, and resources categories have been reduced by 82.4, 85.1, and 87.1%, respectively.     

Genomewide search for dehydrated hereditary stomatocytosis (hereditary xerocytosis): mapping of locus to chromosome 16 (16q23-qter)

Dehydrated hereditary stomatocytosis, also known as "hereditary xerocytosis," is caused by a red blood cell-membrane defect characterized by stomatocytic morphology, increased mean corpuscular hemoglobin concentration, decreased osmotic fragility, increased permeability to the univalent cations Na+ and K+, and an increased proportion of phosphatidylcholine in the membrane. The clinical presentation is heterogeneous, ranging from mild to moderate hemolytic anemia associated with scleral icterus, splenomegaly, and choletithiasis. Iron overload may develop later in life. The disease is transmitted as an autosomal dominant trait. We recruited a large three-generation Irish family affected with DHS and comprising 23 members, of whom 14 were affected and 9 were healthy. Two additional, small families also were included in the study. The DNA samples from the family members were used in a genomewide search to identify, by linkage analysis, the DHS locus. After the exclusion of a portion of the human genome, we obtained conclusive evidence for linkage of DHS to microsatellite markers on the long arm of chromosome 16 (16q23-q24). A maximum two-point LOD score of 6.62 at recombination fraction .00 was obtained with marker D16S520. There are no recombination events defining the telomeric limit of the region, which therefore is quite large. No candidate genes map to this area.     

Comparison of two novel MRAS based strategies for identifying parameters in permanent magnet synchronous motors

Two model reference adaptive system (MRAS) estimators are developed for identifying the parameters of permanent magnet synchronous motors (PMSM) based on the Lyapunov stability theorem and the Popov stability criterion, respectively. The proposed estimators only need online measurement of currents, voltages, and rotor speed to effectively estimate stator resistance, inductance, and rotor flux-linkage simultaneously. The performance of the estimators is compared and verified through simulations and experiments, which show that the two estimators are simple, have good robustness against parameter variation, and are accurate in parameter tracking. However, the estimator based on the Popov stability criterion, which can overcome parameter variation in a practical system, is superior in terms of response speed and convergence speed since there are both proportional and integral units in the estimator, in contrast to only one integral unit in the estimator based on the Lyapunov stability theorem. In addition, the estimator based on the Popov stability criterion does not need the expertise that is required in designing a Lyapunov function.     

Safe driving in a green world: A review of driver performance benchmarks and technologies to support ‘smart’ driving

Road transport is a significant source of both safety and environmental concerns. With climate change and fuel prices increasingly prominent on social and political agendas, many drivers are turning their thoughts to fuel efficient or ‘green’ (i.e., environmentally friendly) driving practices. Many vehicle manufacturers are satisfying this demand by offering green driving feedback or advice tools. However, there is a legitimate concern regarding the effects of such devices on road safety – both from the point of view of change in driving styles, as well as potential distraction caused by the in-vehicle feedback. In this paper, we appraise the benchmarks for safe and green driving, concluding that whilst they largely overlap, there are some specific circumstances in which the goals are in conflict. We go on to review current and emerging in-vehicle information systems which purport to affect safe and/or green driving, and discuss some fundamental ergonomics principles for the design of such devices. The results of the review are being used in the Foot-LITE project, aimed at developing a system to encourage ‘smart’ – that is safe and green – driving.     

Semantic data modelling and visualisation using Noetica

Noetica is a tool for structuring knowledge about concepts and the relationships between them. It differs from typical information systems in that the knowledge it represents is abstract, highly connected, and includes meta-knowledge (knowledge about knowledge). Noetica represents knowledge using a strongly typed graph data model. By providing a rich type system it is possible to represent conceptual information using formalised structures. A class hierarchy provides a basic classification for all objects. This allows for a consistency of representation that is not often found in “free” semantic networks, and gives the ability to easily extend a knowledge model while retaining its semantics.

Visualisation and query tools are provided for this data model. Visualisation can be used to explore complete sets of link-classes, show paths while navigating through the database, or visualise the results of queries. Noetica supports goal-directed queries (a series of user-supplied goals that the system attempts to satisfy in sequence) and pathfinding queries (where the system finds relationships between objects in the database by following links).