全文获取类型
收费全文 | 8775篇 |
免费 | 9篇 |
国内免费 | 1篇 |
专业分类
电工技术 | 3篇 |
综合类 | 8篇 |
化学工业 | 93篇 |
金属工艺 | 10篇 |
机械仪表 | 2篇 |
建筑科学 | 7篇 |
能源动力 | 1篇 |
轻工业 | 83篇 |
水利工程 | 2篇 |
石油天然气 | 3篇 |
武器工业 | 1篇 |
无线电 | 26篇 |
一般工业技术 | 53篇 |
冶金工业 | 8446篇 |
原子能技术 | 8篇 |
自动化技术 | 39篇 |
出版年
2022年 | 4篇 |
2021年 | 9篇 |
2020年 | 7篇 |
2019年 | 5篇 |
2018年 | 6篇 |
2017年 | 5篇 |
2016年 | 4篇 |
2015年 | 3篇 |
2014年 | 7篇 |
2013年 | 8篇 |
2012年 | 11篇 |
2011年 | 8篇 |
2010年 | 6篇 |
2009年 | 10篇 |
2008年 | 14篇 |
2007年 | 15篇 |
2006年 | 20篇 |
2005年 | 12篇 |
2004年 | 23篇 |
2003年 | 19篇 |
2002年 | 7篇 |
2001年 | 10篇 |
2000年 | 12篇 |
1999年 | 280篇 |
1998年 | 2708篇 |
1997年 | 1504篇 |
1996年 | 964篇 |
1995年 | 556篇 |
1994年 | 428篇 |
1993年 | 530篇 |
1992年 | 64篇 |
1991年 | 119篇 |
1990年 | 114篇 |
1989年 | 94篇 |
1988年 | 99篇 |
1987年 | 91篇 |
1986年 | 96篇 |
1985年 | 68篇 |
1984年 | 6篇 |
1983年 | 9篇 |
1982年 | 36篇 |
1981年 | 38篇 |
1980年 | 78篇 |
1979年 | 3篇 |
1978年 | 13篇 |
1977年 | 185篇 |
1976年 | 439篇 |
1975年 | 11篇 |
1955年 | 7篇 |
1934年 | 3篇 |
排序方式: 共有8785条查询结果,搜索用时 0 毫秒
101.
Aminothiols, such as WR-2721 and its active free thiol, WR-1065, reduce mutations from ionizing radiation in exponentially growing cells. In this study, human noncycling G0 T lymphocytes were exposed in vitro to gamma-irradiation in the presence or absence of WR-1065. The five treatment groups were: (a) control; (b) treatment with 4 mM WR-1065; (c) treatment with 3 Gy of gamma-radiation, from a 137Cs source; and (d) and (e) treatment with WR-1065 30 min prior to or 3 h after 3 Gy of gamma-irradiaiton, respectively. A total of 224 cloned HPRT mutants representing 179 independent mutations were analyzed for genetic alterations using multiplex PCR. Ionizing radiation alone significantly increased the percentage of mutations with gross structural alterations compared to controls (P = 0.02). Although the frequency of such large structural mutations was not different from control cells treated with WR-1065 alone, this aminothiol significantly reduced their frequency among irradiated mutants (P = 0.01) when the radioprotector was present during the irradiation. Addition of WR-1065 3 h postirradiation also greatly reduced the percentage of gross structural alterations; however, due to small numbers, this was not statistically significant. This is the first demonstration that the antimutagenicity of WR-1065 in human cells specifically protects against these kinds of large-scale DNA alterations induced by ionizing radiation. WR-1065 and similar aminothiol compounds may afford protection against radiation-induced mutations through polyamine-like processes, e.g., stabilization of chromatin structure, inhibition of cell proliferation, and influences on DNA repair systems. 相似文献
102.
JA Zaia GM Gallez-Hawkins BR Tegtmeier A ter Veer X Li JC Niland SJ Forman 《Canadian Metallurgical Quarterly》1997,176(3):782-785
Late occurrence of cytomegalovirus (CMV) disease after day 100 after bone marrow transplantation has become an increasing problem; whether a quantitative measurement of CMV DNA in plasma by polymerase chain reaction (P-PCR) could be predictive of such disease was investigated. In a prospective study, 117 subjects undergoing allogeneic marrow transplantation were followed for 120 days with weekly CMV blood cultures, with day 35 bronchoalveolar lavage CMV cultures, with weekly CMV P-PCR, and with clinical follow-up for an additional 1-2 years. Despite preemptive ganciclovir, CMV disease occurred in 9% of subjects, with a median time of onset of 176 days. Quantitative CMV P-PCR was associated with the late development of CMV disease (P = .01). Of 43 subjects with positive P-PCR results, 23% developed CMV disease, but no disease occurred in the 74 subjects with negative P-PCR (P < .001), despite the fact that 22% had CMV isolated from lung lavage fluid and 32% had CMV isolated from blood. 相似文献
103.
104.
105.
JA Tumlin JP Lea CE Swanson CL Smith SS Edge JS Someren 《Canadian Metallurgical Quarterly》1997,99(6):1217-1223
1. PD 81,723 has been shown to enhance binding of adenosine to A1 receptors by stabilizing G protein-receptor coupling ('allosteric enhancement'). Evidence has been provided that in the perfused hearts and isolated atria PD 81,723 causes a sensitization to adenosine via this mechanism. 2. We have studied the effect of PD 81,723 in guinea-pig isolated atrial myocytes by use of whole-cell measurement of the muscarinic K+ current (I[K(ACh)]) activated by different Gi-coupled receptors (A1, M2, sphingolipid). PD 81,273 caused inhibition of I[K(ACh)] (IC50 approximately 5 microM) activated by either of the three receptors. Receptor-independent I[K(ACh)] in cells loaded with GTP-gamma-S and background I[K(ACh)], which contributes to the resting conductance of atrial myocytes, were equally sensitive to PD 81,723. At no combination of concentrations of adenosine and PD 81,723 could an enhancing effect be detected. 3. The compound was active from the outside only. Loading of the cells with PD 81,723 (50 microM) via the patch pipette did not affect either I[K(ACh)] or its sensitivity to adenosine. We suggest that PD 81,723 acts as an inhibitor of inward rectifying K+ channels; this is supported by the finding that ventricular I(K1), which shares a large degree of homology with the proteins (GIRK1/GIRK4) forming I[K(ACh)] but is not G protein-gated, was also blocked by this compound. 4. It is concluded that the functional effects of PD 81,723 described in the literature are not mediated by the A1 adenosine receptor-Gi-I[K(ACh)] pathway. 相似文献
106.
Chondromas are benign tumours of cartilage which are rare in the head and neck. We present a case report of a chondroma in the neck of condyle and demonstrate the value of multiplanar spiral CT and the limitations of 3D reconstruction. 相似文献
107.
108.
109.
110.
In recent years fracture fixation in the horse has changed significantly. New devices, mainly adapted from the human field, have been successfully introduced into large animal surgery. Examples of such implants include the DCS/DHS implant system, the self-tapping screw, the cannulated screw, and the pinless external fixator. However, new devices have also been developed exclusively for equine fracture management, including the interlocking intramedullary nail and the external skeletal fixation device. With these devices the surgeon has more options for repairing fractures in horses. Nevertheless, many problems are still unsolved. Indications exist that during the next few years new, exciting fracture fixation systems will be developed, providing further advancements in the quest for the ideal implant for horses. However, the development stages of these devices are such that mentioning the possibilities here is premature. 相似文献