Green chemical processes play a crucial role in sustainable development, and efficient recyclable catalysts that can be conveniently applied in various chemical reactions are the key elements for the development of sustainable synthetic processes. Many organic transformations rely on Lewis and Br?nsted acid catalysts, and such molecules have been widely studied in organic synthesis. Over the years, researchers have looked for Lewis acid catalysts that provide high selectivity and high turnover frequency but are also stable in aqueous media and recoverable. Since the first preparation of trifluoromethanesulfonic acid by Hazeldine (triflic acid, HOTf), researchers have synthesized and used numerous metal triflates in a variety of organic reactions. Even though the rare earth metal triflates have played a major role in these studies, the majority of rare earth triflates lack one or more of the primary properties of sustainable catalysts: low cost and easy availability of the metals, easy preparation of triflates, aqueous/thermal stability, recyclability, and catalytic efficiency. In this Account, we describe the synthetic applications of Ga(OTf)(3) and its advantages over similar catalysts. Ga(OTf)(3) can be conveniently prepared from gallium metal or gallium chloride in excess of trifluoromethanesulfonic acid (triflic acid) under reflux. Among many Lewis acid catalysts recently studied, Ga(OTf)(3) is water tolerant and soluble and requires very low catalyst loading to drive various acid-catalyzed reactions including Friedel-Crafts alkylation, hydroxyalkylation, and acylation selectively and efficiently. In many reactions Ga(OTf)(3) demonstrated high chemo- and regioselectivity, high yields, excellent stability, and recyclability. We successfully synthesized many biologically active heterocycles and their fluoroanalogs under mild conditions. Many challenging reactions such as the ketonic Strecker reactions proceed efficiently via Ga(OTf)(3) catalysis. Because it is stable in water, this catalyst provides the opportunity to study substrates and develop new synthetic protocols in aqueous media, significantly reducing the production of hazardous waste from organic solvents and toxic catalyst systems. 相似文献
The general blueprint for the design of monoamine oxidase-B (MAO-B) inhibitors has been based on two phenyl or heteronuclei linked via a spacer of appropriate length. In this study, 1-[4-(morpholin-4-yl)phenyl]-5-phenylpenta-2,4-dien-1-one (MO10) was prepared by the condensation of 4′-morpholinoacetophenone and cinnamaldehyde in basic alcoholic medium. MO10 was assessed for inhibitory activity against two human MAO isoforms, MAO-A and MAO-B. Interestingly, MO10 showed a remarkable inhibition against MAO-B with an IC50 value of 0.044 μM along with a selectivity index of 366.13. The IC50 value was better than that of lazabemide (IC50 value of 0.063 μM), which was used as a reference. Kinetics studies revealed that MO10 acted as a competitive inhibitor of MAO-B, with a Ki value of 0.0080 μM. The observation of recovery of MAO-B inhibition, compared to reference levels showed MO10 to be a reversible inhibitor. MTT assays showed that MO10 was nontoxic to normal VERO cells with an IC50 value of 195.44 μg/mL. SwissADME predicted that MO10 provided advantageous pharmacokinetics profiles for developing agents acting on the central nervous system, that is, high passive human gastrointestinal absorption and blood–brain barrier permeability. Molecular docking simulations showed that MO10 properly entered the aromatic cage formed by Y435, Y398, and FAD of the active site of MAO-B. On the basis of these results, MO10 can be considered a promising starting compound in development of agents for the treatment of various neurodegenerative disorders. 相似文献
This study deals with the utility of mini spray dryer process to improve the dispersibility, of graphene oxide(GO) and its application for high-performance supercapacitor. Initially, the neutral solution of GO was obtained using the modified Hummer's method. After this, the prepared GO solution was processed by mini spray dryer to obtain a more purified, lighter, and dispersed form of GO which is named as spray dryer processed GO (SPGO). The SPGO thus obtained showed excellent dispersibility behavior with various solvents, which is not found in case of conventional oven drying. Furthermore, utility of SPGO and its reduced form (r-SPGO) for supercapacitor applications have been investigated. Results obtained from the cyclic voltammetry(CV) analysis, impedance, and charge-discharge behavior of supercapacitor fabricated using r-SPGO shows enhanced features. Therefore, the simple spray dried GO and its reduced form, that is, r-SPGO can be utilized as a potential candidate for the supercapacitor application. Herein, as synthesized SPGO exhibited the specific capacitance of 12.07 and 37.6 F/g with PVA-H3PO4 and 1 mol/L H3PO4, respectively, at a scan rate of 5 mV/s. On the other hand, reduced form of SPGO, that is, r-SPGO showed the specific capacitance of 27.16 and 230 F/g with PVA-H3PO4 and 1 mol/L H3PO4, respectively. 相似文献
The moisture absorption of cyanate ester modified epoxy resin matrices has been studied under thermal spiking conditions. Enhanced moisture absorption has been observed at spike-temperatures above 120 °C. The results of the desorption studies on both control specimens and the spiked specimens showed that some of the water molecules remained entrained in the polymer. It is postulated that this water could be associated with that which is hydrogen bonded or from the hydrolysis of isolated residual cyanate ester groups because the concentration of entrained water remains constant at spike-temperatures below 180 °C. Above 180 °C a thermally activated process, leading to chain scission as indicated by a reduced recoverability of the glass transition temperature (Tg) on drying.On isothermal resorption, the moisture concentration was found to be similar to that achieved through thermal spiking, showing that the entrained water at the lower spike-temperatures can also be achieved under mild conditions. The Tg is reversibly recovered to within 5 °C, which indicates a degree of relaxation rather than degradation. The moisture diffusion coefficient estimated from the resorption curves is lower than those estimated from the absorption and desorption curves. The isothermal resorption diffusion coefficient also decreased with increasing spike temperature. It is proposed that thermal spiking induced a relaxation of the network but as the spike-temperature approaches the transition region of the wet polymer, further hydrolytically induced relaxation events become feasible. 相似文献
Many moth pheromones are composed of mixtures of acetates of long‐chain (≥10 carbon) fatty alcohols. Moth pheromone precursors such as fatty acids and fatty alcohols can be produced in yeast by the heterologous expression of genes involved in insect pheromone production. Acetyltransferases that subsequently catalyze the formation of acetates by transfer of the acetate unit from acetyl‐CoA to a fatty alcohol have been postulated in pheromone biosynthesis. However, so far no fatty alcohol acetyltransferases responsible for the production of straight chain alkyl acetate pheromone components in insects have been identified. In search for a non‐insect acetyltransferase alternative, we expressed a plant‐derived diacylglycerol acetyltransferase (EaDAcT) (EC 2.3.1.20) cloned from the seed of the burning bush (Euonymus alatus) in a yeast system. EaDAcT transformed various fatty alcohol insect pheromone precursors into acetates but we also found high background acetylation activities. Only one enzyme in yeast was shown to be responsible for the majority of that background activity, the acetyltransferase ATF1 (EC 2.3.1.84). We further investigated the usefulness of ATF1 for the conversion of moth pheromone alcohols into acetates in comparison with EaDAcT. Overexpression of ATF1 revealed that it was capable of acetylating these fatty alcohols with chain lengths from 10 to 18 carbons with up to 27‐ and 10‐fold higher in vivo and in vitro efficiency, respectively, compared to EaDAcT. The ATF1 enzyme thus has the potential to serve as the missing enzyme in the reconstruction of the biosynthetic pathway of insect acetate pheromones from precursor fatty acids in yeast. 相似文献
A novel class of organic‐inorganic polymer hybrids was developed by melt‐blending up to 50 (v/v) % [about 83 (w/w) %] tin‐based polyphosphate glass (Pglass) and low‐density polyethylene (LDPE) in conventional plastics processing equipment. The liquid‐ and solid‐state rheology of the polymer hybrids was studied under oscillatory shear flow and deformation to understand the behavior of these materials and to accelerate efforts to melt process the Pglass with organic polymers. All the materials were found to be linearly viscoelastic in the range of temperature and frequencies examined and their viscoelastic functions increased with increasing Pglass concentration. The Pglass significantly enhanced the shear‐thinning characteristics of the Pglass‐LDPE hybrid, indicating the presence of nonlinear chemical and physical interactions between the hybrid components. Morphological examination of the materials by scanning electron microscopy revealed interesting evolution of microstructure of the Pglass phase from droplets (or round beads) to elongated and interpenetrating network structures as the glass concentration was increased in the Pglass‐LDPE hybrids. Melt viscosities of the materials were well described by a simple power‐law equation and a Maxwellian (Hookean) model with three relaxation times. Time‐temperature superpositioning (TTS) of the complex viscosity versus frequency data was excellent at 170°C < T < 220°C and the temperature dependencies of the shift factors conformed excellently well to predictions from an Arrhenius‐type relation, enabling calculation of the flow‐activation energies (25–285 kj/mol) for the materials. The beneficial function of the Pglass in the hybrid system was significantly enhanced by pre‐treating the glass with coupling agents prior to incorporating them into the Pglass‐LDPE hybrids. 相似文献
Extensive experimental tests and a computational study of the performance in a cross-flow air classifier have been carried out. A computational fluid dynamics (CFD) package—Fluent—is used to first understand and explain why the cuts or the sharpness of cut of this classifier are not as sharp as they ought to be, and then to optimize the geometry and operational conditions.
Flow fields of the classifier under various set-up conditions and geometry were measured by using laser Doppler anemometry (LDA). Using sieve analyses and the HELOS-laser method, the patterns of behaviour of separation parameters such as cut size and sharpness of cut have been investigated at different boundary conditions.
Using the Fluent package, a two-dimensional computational fluid dynamics model has been developed. The model is based on the Euler–Lagrangian approach. Different turbulence models have been tested. Both Fluent 4.5, with a structured grid, and Fluent 5.1, with structured and unstructured grids, have been used.
Discussions and analyses of the experimental, as well as the computational results, are presented. The simulation with a structured grid shows good agreement with experimental data, except for the sharpness of cut. The reasons of poor performance of the classifier have been found. The geometry is optimized and other conditions were also improved. The performance of the classifier is improved. The experimental observations together with the computed results should increase the depth of understanding of the underlying mechanisms. 相似文献