Truthful Mechanisms for Selfish Routing and Two-Parameter Agents

We prove a general monotonicity result about Nash flows in directed networks, which generalizes earlier results and can be used for the design of truthful mechanisms in the setting where each edge of the network is controlled by a different selfish agent, who incurs costs when her edge is used.     

Modeling without categorical variables: a mixed-integer nonlinear program for the optimization of thermal insulation systems

Optimal design applications are often modeled by using categorical variables to express discrete design decisions, such as material types. A disadvantage of using categorical variables is the lack of continuous relaxations, which precludes the use of modern integer programming techniques. We show how to express categorical variables with standard integer modeling techniques, and we illustrate this approach on a load-bearing thermal insulation system. The system consists of a number of insulators of different materials and intercepts that minimize the heat flow from a hot surface to a cold surface. Our new model allows us to employ black-box modeling languages and solvers and illustrates the interplay between integer and nonlinear modeling techniques. We present numerical experience that illustrates the advantage of the standard integer model.     

Compression depth estimation for CPR quality assessment using DSP on accelerometer signals

Chest compression is a vital part of cardiopulmonary resuscitation (CPR). This paper demonstrates how the compression depth can be estimated using the principles of inertia navigation. The proposed method uses accelerometer sensors, one placed on the patient's chest, the other beside the patient. The acceleration-to-position conversion is performed using discrete-time digital signal processing (DSP). Instability problems due to integration are combated using a set of boundary conditions. The proposed algorithm is tested on a mannequin in harsh environments, where the patient is exposed to external forces as in a boat or car, as well as improper sensor/patient alignment. The overall performance is an estimation depth error of 4.3 mm in these environments, which is reduced to 1.6 mm in a regular, flat-floor controlled environment.     

Arbitrary spot location diffractive beam-splitting elements

Diffractive beam-splitting elements are typically designed for replicating beams on positions belonging to an equidistant grid in the spatial spectrum. The parameter of the output grid follows directly from the period of the beam-splitter transmission through the grating equation. Our objective is to develop design strategies allowing a more accurate positioning of the replicated beams. Issues occurring when the output grid parameter is decreased below the output beam width are discussed and shown to be avoidable. Furthermore, a design algorithm is introduced, which permits an arbitrary positioning of the replicated beams. This algorithm is constructed for high computational efficiency by utilizing fast Fourier transform operations in the major part of its iterations.     

Exploring Problems with Function Analysis. Experimental Insights for Team Management

Problem analysis is an important, but mainly neglected part of the problem‐solving process. The theory of inventive problem solving (TRIZ) offers an instrument called function analysis to conduct problem analysis, which is especially useful for exploring a problem. This process is based on an idea applied in different creativity techniques, saying that behind one problem statement many problem formulations may occur, which allows for evaluation and selection of those problem formulations before looking for problem solutions. The application of function analysis as a tool for teams is recommended for a number of reasons. In so doing so, two main questions arise: (i) Should function analysis be used with the help of an external moderator? and: (ii) Should it be applied with currently available special software? After introducing the basics of function analysis this article provides key findings deducted from an experiment addressing these questions. An important result is the remarkable learning effect, which occurs while using function analysis in teams. By applying function analysis in R&D, companies will be able to get deeper and team‐based problem explorations, which may lead to maturing problem solutions.     

Anagrelide in control of myeloproliferative thrombocythemia: long-term experiences in 6 patients

Symptomatic or asymptomatic chronic elevation of platelet count can be observed in all forms of myeloproliferative disorders (MPD). Benefits and limitations of the traditional platelet-reducing agents, such as radioactive phosphorus, alkylating agents, hydroxyurea and interferon alpha, are well known and have been largely described. Anagrelide (Agrelin) is an additional newer drug with a selective platelet-lowering effect. We describe our own long-term experience in 6 patients with MPD who were treated with anagrelide as part of a compassionate-use protocol between April 1991 and August 1997. The median duration of therapy was 54 months (range 17 to 75 months), with an overall response rate of 100% (complete and partial response for at least 4 weeks). The initial median platelet count of 1211 x 10(9)/l (range 847 to 2050 x 10(9)/l) was reduced rapidly and lastingly to 570 x 10(9)/l (range 216 to 667 x 10(9)/l) at the time of the last control. Under treatment with anagrelide 4 of the 6 patients showed a reduction of disease-associated symptoms or complications. Adverse reactions were generally mild and transitory, and no interruption or cessation of therapy was required. Development of drug resistance or late adverse events were not observed. Treatment with anagrelide is effective, safe and in our opinion easy to administer. It also appears to be suitable for long-term administration.     

On Scheduling in a Semi-Ordered Flow Shop Without Intermediate Queues

The dynamic programming solution offered is of complexity O(n²) and is a significant improvement over the implicit enumeration procedure previously suggested by Arora and Rana in an article in the September 1980 issue of TRANSACTIONS.