Cardiotrophin-1, a cytokine present in embryonic muscle, supports long-term survival of spinal motoneurons

Activation of courtship behavior in male red-sided garter snakes is independent of androgens. Only exposure to extended periods of low temperature with subsequent warming stimulates courtship in males. The pineal gland is thought to transduce temperature as well as photoperiodic information in reptiles. Therefore, we explored the relationship of the pineal and melatonin to sexual behavior in this species. Pinealectomy of male garter snakes disrupted sexual behavior upon emergence from a 17-week period of low temperature in approximately 60% of treated individuals in each of the 3 years of study. However, 40% of the males were unaffected by the pinealectomy, engaging in vigorous courtship. Administration of exogenous, chronic melatonin did not significantly modulate the effect of pinealectomy. Upon pinealectomy in the autumn (before hibernation), plasma levels of melatonin fell. However, upon emergence from hibernation, melatonin levels in pinealectomized (PINX) and sham-treated (SHAM) animals were equivalent, indicating extrapineal source(s) of melatonin. However, PINX males did not exhibit a diel cycle in melatonin levels upon emergence. Instead, melatonin remained elevated through the subsequent 24-hr period. SHAMs did exhibit a diel cycle. Ten days after emergence, PINX animals either had a disrupted/abnormal melatonin cycle and were non-courters or had a cycle similar to SHAM males and courted. Therefore, a normal diel cycle of melatonin appeared necessary for the proper expression of courtship behavior. These results suggest that the pineal in snakes 1) is part of a complex, multi-oscillator system as it is in birds and lizards and 2) may play a role in maintaining polymorphism in timing of reproductive behavior.     

High frequency GaAs switched capacitor filter implemented with GaAs insulated gate FET switches

A switched capacitor filter implemented with 5 mu m GaAs IGFET switches and GaAs MESFET operational amplifiers is presented. The circuit is clocked at 25 MHz. By scaling to 1 mu m IGFETs, a switching speed of about 625 MHz should be attainable. Use of GaAs IGFET switches is shown to greatly reduce power consumption and complexity of the circuit. The low frequency switching instability of the GaAs IGFET is shown to be of no consequence in this application.<>     

Premium honeys: Response of sensory panelists

Four honeys and one synthetic ‘honey’ were ranked by 62 panelists for relative acceptability; willingness to buy was ranked after price information was provided. Data were analyzed with the R-index procedure and Friedman ranked sums test. Honey floral source and production location differed. Panelists completed a questionnaire concerning food selection and perception and selection of honey. Instrumental techniques were used to characterize the honeys.

Honey was perceived by these panelists to have a unique flavor and positive image. Alaska wildflower, a fireweed table honey and Alaska fireweed/clover were the most acceptable. Acceptability did not necessarily correspond to willingness to buy. Similar results were obtained from both the R-index and rank sums analyses. The instrumental assessment of color and acceptability were significantly correlated. Generally, characteristics that distinguish premium from table honeys were unimportant in the selection process used by these panelists.     

Control orientation in women alcoholics

Women alcoholics had higher scores than women social drinkers (indicating greater external control orientation) on both the Internal-External Locus of Control Scale and a Locus of Drinking Control Scale.     

Chemical changes in almonds throughout storage: modeling the effects of common industry practices

Further investigations of almond degradation under typical industrial storage conditions from a quantitative perspective are warranted. This study modeled effects of packaging, temperature (TEMP), relative humidity (RH) and roasting on chemical attributes of almonds stored according to common industry practices throughout 16 months. Roasted samples were stored in high-barrier bags (HBB) or polypropylene bags (PPB) at multiple combinations of TEMP and RH. Raw samples were held in unlined cardboard cartons (UC) or PPB under the same conditions. Almonds were assessed bimonthly for oxidation products, free fatty acids, moisture content and water activity. Results indicated roasting almonds improved quality preservation. Models showed HBB (rather than PPB) to provide benefits to stability comparable to reductions in storage TEMP of ~15 to 30 °C. PPB (rather than UC) showed benefits to peroxide formation of similar magnitude. Our data shows HBB to be a superior packaging choice, and UC to associate with the greatest rates of degradation.     

An endogenous calcium oscillator may control early embryonic division

Transient elevations in the concentration of free cytosolic calcium ion ([Ca2+]i) promote cell phase transitions in early embryonic division and persist even if these transitions are blocked. These observations suggest that a [Ca2+]i oscillator is an essential timing element of the early embryonic "master clock." We explore this possibility by coupling a [Ca2+]i oscillator model to an early embryonic cell cycle model based on the protein interactions that govern the activity of the M-phase-promoting factor (MPF). We hypothesize three dynamical states of the MPF system and choose parameter sets to represent each. We then investigate how [Ca2+]i dynamics may control early embryonic division in both sea urchin and Xenopus embryos. To investigate both systems, distinct [Ca2+]i profiles matching those observed in sea urchin embryos (in which [Ca2+]i exhibits sharp transients) and Xenopus embryos (in which [Ca2+]i is elevated and oscillates sinusoidally) are imposed on each of the hypothesized dynamical states of MPF. In the first hypothesis, [Ca2+]i oscillations entrain the autonomous MPF oscillator. In the second and third hypotheses, where the MPF system rests in excitatory and bistable states, respectively, [Ca2+]i oscillations drive MPF activation cycles. Simulation results show that hypotheses two and three, in which a [Ca2+]i oscillator is a fundamental timing element of the master clock, best account for key experimental observations and the questions that they raise. Finally, we propose experiments to elucidate further [Ca2+]i regulation and the fundamental components of the early embryonic master clock.     

Nanograin magnetoresistive manganite coatings for EMI shielding against directed energy pulses

Two magnetoresistive manganites, La_0.83Sr_0.17MnO₃ and La_0.7Sr_0.3MnO₃, are synthesized by the environmentally friendly “deposition by aqueous acetate solution (DAAS)” technique. The manganite film has a grain size of 100 nm, and can be processed as thinly as 0.03 μm per layer, while the powder form has a crystallite size of 40 nm. These magnetoresistive materials are shown to be effective and inexpensive electromagnetic interference (EMI) shield for the extremely low frequency (ELF) EM fields. The electrical resistance of manganites is very sensitive to external influences, such as temperature and electromagnetic fields. Both permeability (μ) and conductivity (σ) of manganites tend to increase with increasing applied magnetic field. The manganites have been shown to “react” to field increases in a way that is particularly useful for shielding EMI field fluctuations (e.g., due to current or voltage spikes).

The manganite properties, e.g., crystal structure, film morphology, radiation absorption and reflection, electrical resistivity, and magnetization, etc., have been measured. The ceramic manganites have a metal–insulator transition at 300 K or higher, and are suitable for a room temperature operation. A thin film (approx. 0.1 μm) of La_0.83Sr_0.17MnO₃ was fabricated on a quartz tube or refractory ceramic fiber blanket. Using this thin manganite film, the EMI shielding effectiveness for the measured E-field attenuation is similar to that of a 25 μm thickness of copper tube, aluminum foil, and silver–nickel particle-dispersed paper. The silver–nickel impregnated paper has an EMI shielding effectiveness of 35 dB at 10 kHz, and 15 dB at 60 Hz (or frequency above 1 MHz). The ceramic manganites are chemically inert, thermally stable, and mechanically flexible. They provide low cost EMI shielding against directed energy pulses and may serve as a “signature reduction” barrier.     

Computer Applications in Intelligent Compaction

The term “intelligent compaction” is now heard so often one might believe that the method used for documenting and controlling the quality of hot-mix asphalt pavement has evolved to a state of total commercial and engineering acceptance. In fact, today’s most-used process for determining the density of an asphalt mat uses 1960’s technology. Now, however, the responsibility for quality control (QC) of the paving and compaction process has largely been given to the contractor. This shift in responsibility comes at a time when the construction industry as a whole is faced with the worst labor shortage in history, limiting the number of qualified QC technicians and equipment operators. Recently, researchers introduced a patented system that, when mounted on a vibratory asphalt compactor, can render an asphalt density reading (in pounds per cubic foot) every 1?s in real time. This paper briefly describes the system and details the essential contributions made by computer hardware and software to a successful onboard asphalt density measuring system.     

Growth in working memory and mathematical problem solving in children at risk and not at risk for serious math difficulties.

The influence of cognitive growth in working memory (WM) on mathematical problem solution accuracy was examined in elementary school children (N = 353) at risk and not at risk for serious math problem solving difficulties. A battery of tests was administered that assessed problem solving, achievement, and cognitive processing (WM, inhibition, naming speed, phonological coding) in children in 1st, 2nd, and 3rd grade across 3 testing waves. The results were that (a) children identified as at risk for serious math problem solving difficulties in Wave 1 showed less growth rate and lower levels of performance on cognitive measures than did children not at risk; (b) fluid intelligence and 2 components of WM (central executive, visual-spatial sketchpad) in Wave 1 (Year 1) predicted Wave 3 word problem solving solution accuracy; and (c) growth in the central executive and phonological storage component of WM was related to growth in solution accuracy. The results support the notion that growth in WM is an important predictor of children's problem solving beyond the contribution of reading, calculation skills, and individual differences in phonological processing, inhibition, and processing speed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)