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斑蝥素及其衍生物的作用机制及临床应用 总被引:3,自引:0,他引:3
斑蝥为芫菁科昆虫,南方大斑蝥Mylabrisphalerala Pallas或黄黑小斑蝥Mylabris cichoriiLinnaeus的干燥全虫,味辛、热,有大毒,在我国已经应用两千多年,是一种重要的昆虫类药物。现代药学研究表明其主要药用成分是斑蝥素,主要用于治疗肝癌、食管癌及胃癌。去甲斑蝥素(norcantharidin,NCTD)为斑蝥素的衍生物,是我国首先合成的具有较强抗肿瘤活性和独特升高白细胞作用的新型杭肿瘤药物。明显增强了抗癌效果,并显著降低了斑蝥素对人体的毒副作用。文章对国内外有关斑蝥素及其衍生物的作用机制和临床应用现状进行了综述。 相似文献
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Tea contains antioxidant compounds, such as (-)-epicatechin (EC), (-)-epigallocatechin (EGC), (-)-epicatechin gallate (ECG), (-)-epigallocatechin gallate (EGCG), gallic acid and caffeine. The antioxidant activity of these compounds as well as 1,3,7-trimethyluric acid (the major metabolite of caffeine) was evaluated using the 2,2-diphenyl-1-picrylhydrazyl radical (DPPH). The antiradical ability according to the EC50 was EGCG > ECG > EGC > gallic acid > EC > BHT > 1,3,7-trimethyluric acid > caffeine. The time for these compounds to reach the steady state was considered, and the concept of antioxidant efficiency (AE50 ) involving the EC50 and the time to reach the steady state was used to evaluate the antiradical efficacy. The order of antiradical efficiency according to AE50 was ECG gallic acid > EGCG > EC > EGC > BHT > 1,3,7-trimethyluric acid > caffeine. 相似文献
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廷璋 《高科技纤维与应用》2011,36(1):32-35,43
综述了日本和欧美静电纺丝纳米纤维技术和制品的新进展、已产业化的品种和正在研发的多样新品种和新用途,指出未来的研发方向和动向. 相似文献
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THE DEVELOPMENT OF A MACHINE VISION SYSTEM FOR SHIITAKE GRADING 总被引:1,自引:0,他引:1
A grading system was developed to classify shiitake automatically into various grades of quality in terms of size, shape and color. A shiitake is scanned with a color charge‐coupled‐device camera and then various geometrical and color characteristics are determined by image processing. The online grading procedure includes the following sequences in processing dried shiitake: (a) color abnormality is eliminated by image analysis; (b) broken caps are detected by calculation of the area‐to‐perimeter ratio; and (c) size is determined by pixel counting from the bottom view. Image processing and algorithmic manipulations are done on a personal computer (PC) while grading is carried out by a programmable logic controller (PLC). The PLC accepts grading instructions from the PC, hence controls the grading mechanisms. Pilot system validation was done on 250 dried shiitake samples and resulted in a 97.6% accuracy rate. This result is better than that by visual inspection. A complete grading cycle takes 4.8 s, of which the PC unit participates 0.3–0.7 s depending on the physical complexity of the shiitake being processed. 相似文献
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GIOVANNA D. ALEMÁN MARCIA WALKER DANIEL F. FARKAS J. ANTONIO TORRES EDMUND Y. TING SIGURD C. MORDRE ADRIAN C.O. HAWES 《Journal of food science》1996,61(2):388-390
Sinusoidal and step-pressure pulses were compared with static pressure treatments for the inactivation of Saccharomyces cerevisiae 2407-1a in pineapple juice. No inactivation was observed after 40–4,000 fast sinusoidal pulses (10 cycles/s) at 4–400 sec in the 235–270 MPa range. Static 270 MPa treatments at 40 and 400 sec resulted in 0.7 and 5.1 decimal reductions, respectively. Slower 0–270 MPa step pulses at 0.1 (10 pulses), 1 (100 pulses), and 2 (200 pulses) cycles/s with 100 sec total on-pressure time resulted in 3.3, 3.5, and 3.3 decimal reductions, respectively. A comparable static pressure treatment resulted in 2.5 decimal reductions. Changing the on-pressure/off-pressure time ratio (3:1, 3:3 and 1:3) showed that treatments with longer on-pressure time, e.g., 0.6 sec on-pressure and 0.2 sec off-pressure were significantly more effective showing nearly a 4 decimal reduction in 100 sec. 相似文献