Wheel/rail contact dynamics in turnout negotiations with combined nodal and non-conformal contact approach

In railroad turnouts, geometries of tongue and crossing rails are very complex and their shapes are changing along the track. Therefore, wheels are subjected to not only tread and flange contacts, but also the back-of-flange and top-of-flange contacts in the case of spring switches of tram vehicles. For this reason, one needs to deal with significant jumps in contact points for solving wheel/rail contact problems in turnout, and an accurate prediction of jumps in contact points is one of the most important issues that need to be carefully handled in the dynamic simulation of vehicle/turnout interactions. In this investigation, a numerical procedure that can be used for solving such a complex wheel/rail contact problem in turnout is proposed. In particular, a combined nodal and non-conformal contact approach is developed such that significant jumps in contact points are detected using the nodal search, while the exact location of contact point is then determined with continuous surface parameterizations using non-conformal contact equations. With this combined nodal and non-conformal contact approach for the contact geometry analysis of vehicle/turnout interactions, multiple look-up contact tables can be generated in an efficient way without losing accuracy. Since detailed contact search is performed off-line to obtain look-up contact tables, significant changes in contact points in turnout can be efficiently predicted on-line with tabular data to be interpolated in a standard way. Several numerical examples are presented in order to demonstrate the use of the numerical procedure developed in this investigation.     

Cognitive model of team cooperation in en-route air traffic control

Since controller teams are in charge of en-route air traffic control, team cooperation is a key issue for good control performance. We conducted ethnographic field observation at the Tokyo Area Control Center and then analyzed the obtained data to develop a cognitive model of team cooperation in en-route air traffic control. We segmented conversational records, behavioral records, and so on by control unit, and then clarified relations between the segments and identified expert knowledge and judgment behind them. Cognitive processes of controller teams were reconstructed based on a concept of distributed cognition. The analysis revealed that the mutual belief model is applicable to team cooperation processes, the role assignment of tasks within a controller team is implicit and that control plans are implemented smoothly once team situation awareness has been established. A cognitive model of controllers?? team cooperation has been constructed based on these findings.     

Effects of 2-Hz and 60-Hz electrical stimulation on the microstructure of beef

A comparative electron-microscope study was made of the structural changes brought about in bovine longissimus dorsi muscle by 2-Hz and 60-Hz electrical stimulation. Apart from the frequency difference, the two treatments were identical: 500V AC, 600 pulses (2Hz × 300s and 60 Hz × 10 s), and a time of application of about 40 min post mortem. The low-frequency current produced no detectable tissue disruption or irregularity in sarcomere length, whereas the 60-Hz treatment caused widespread supercontraction and the formation of contraction nodes; many sarcomeres in the internodal zones were stretched or fractured. The observations confirm and extend those of our earlier light-microscope study, and support the view that fiber disruption contributes significantly to the tenderizing effect of high-voltage electrical stimulation.     

Interdiffusion inα solid solutions of the Cu-Zn-Sn system

The interdiffusion coefficients in the f c c phase of Cu-Zn-Sn alloys, , have been determined at 1073 K. The concentration profiles indicate that the diffusion rate of tin is greater than that of zinc in the Cu-Zn-Sn alloy. The diffusion paths show the typical S-shaped curves. All of the four interdiffusion coefficients are positive and they are very sensitive to the solute concentration. The atomic mobilities of the three diffusing elements in Kirkendall planes increase in the order of Cu, Zn, Sn. The interaction energy of the Cu-Sn bond is much larger than that of the Zn-Sn bond. From the results of the present work it seems that the Onsager reciprocal relation holds in the a phase of the Cu-Zn-Sn system.     

Treatment of Oxidative Stress with Exosomes in Myocardial Ischemia

A thrombus in a coronary artery causes ischemia, which eventually leads to myocardial infarction (MI) if not removed. However, removal generates reactive oxygen species (ROS), which causes ischemia–reperfusion (I/R) injury that damages the tissue and exacerbates the resulting MI. The mechanism of I/R injury is currently extensively understood. However, supplementation of exogenous antioxidants is ineffective against oxidative stress (OS). Enhancing the ability of endogenous antioxidants may be a more effective way to treat OS, and exosomes may play a role as targeted carriers. Exosomes are nanosized vesicles wrapped in biofilms which contain various complex RNAs and proteins. They are important intermediate carriers of intercellular communication and material exchange. In recent years, diagnosis and treatment with exosomes in cardiovascular diseases have gained considerable attention. Herein, we review the new findings of exosomes in the regulation of OS in coronary heart disease, discuss the possibility of exosomes as carriers for the targeted regulation of endogenous ROS generation, and compare the advantages of exosome therapy with those of stem-cell therapy. Finally, we explore several miRNAs found in exosomes against OS.     

MiR-10a in Pancreatic Juice as a Biomarker for Invasive Intraductal Papillary Mucinous Neoplasm by miRNA Sequencing

New biomarkers are needed to further stratify the risk of malignancy in intraductal papillary mucinous neoplasm (IPMN). Although microRNAs (miRNAs) are expected to be stable biomarkers, they can vary owing to a lack of definite internal controls. To identify universal biomarkers for invasive IPMN, we performed miRNA sequencing using tumor-normal paired samples. A total of 19 resected tissues and 13 pancreatic juice samples from 32 IPMN patients were analyzed for miRNA expression by next-generation sequencing with a two-step normalization of miRNA sequence data. The miRNAs involved in IPMN associated with invasive carcinoma were identified from this tissue analysis and further verified with the pancreatic juice samples. From the tumor-normal paired tissue analysis of the expression levels of 2792 miRNAs, 20 upregulated and 17 downregulated miRNAs were identified. In IPMN associated with invasive carcinoma (INV), miR-10a-5p and miR-221-3p were upregulated and miR-148a-3p was downregulated when compared with noninvasive IPMN. When these findings were further validated with pancreatic juice samples, miR-10a-5p was found to be elevated in INV (p = 0.002). Therefore, three differentially expressed miRNAs were identified in tissues with INV, and the expression of miR-10a-5p was also elevated in pancreatic juice samples with INV. MiR-10a-5p is a promising additional biomarker for invasive IPMN.     

Kinetics of hydrogen absorption and desorption of magnesium nickel alloy

Reaction rates in the Mg₂Ni---H₂ system are still unclear, although they are needed for the process/optimization of hydrogen storage reactors. In this article, the rates of hydrogen absorption and desorption of the magnesium nickel alloy were investigated at different pressures up to 2.0 MPa using a constant-temperature thermogravimetric method. The powder of the alloy was microencapsulated with copper to improve the alloy properties (such as cycling strength) as a pretreatment. In the experiments, weight changes of the smallest amount possible of samples were monitored with the help of an ultra-accurate thermobalance, in order to avoid changes of the sample temperature due to the heat of the reaction. The reaction curves obtained revealed unique dependence of temperature and pressure and influence of thermal hysterisis. It is also possible that hydrogen-absorption and-desorption rates of this hydrogen storage alloy are expressed by the rate equation of first-order reversible reaction.     

A New Process to Make a Porous PTFE Structure from Aqueous PTFE Dispersion with the Help of Hydrogel

A novel method to make a porous material having relatively large cell diameter (200–300 m), which consisted of mainly poly(tetrafluoroethylene) (PTFE), was developed from aqueous PTFE dispersion by using the characteristics of hydrogel with the addition of carbon nanofiber (CNF). The porous material was produced as follows: firstly, an aqueous agar gel containing PTFE and CNF was prepared; secondly, the gel was freeze-dried; thirdly, the dried gel was heat-treated at 400°C where the agar was almost decomposed and PTFE became molten. The porous material showed electric conductivity (about 50 ), high porosity (about 96 vol%), and relatively uniform cell structures without shrinkage during freeze drying and heat treatment. While the method without CNF resulted in large shrinkage during heat treatment, meaning that CNF prevented the shrinkage. It was explained by the idea that the existence of rigid CNF, which was dispersed in the cell wall, prohibited the shrinkage of PTFE during heat treatment. It was unexpectedly found by SEM analysis that the porous materials had another macro-porous structure inside the cell wall, suggesting that the developed materials had a double porous structure.