The untranslated first exon ''exon 0S'' of the rat estrogen receptor (ER) gene

Occasionally, ipsilateral ischemia develops following the groin insertion of an intra-aortic balloon catheter. Various treatment options have evolved, and include replacing the catheter in the opposite groin, removing it completely, or performing a femorofemoral bypass to deliver blood flow below the catheter. Outlined in this paper is a simple method to restore blood flow to a threatened limb, during femoral artery exploration, in the presence of an intra-aortic balloon. This method is also appropriate for optimal positioning of the balloon catheter prior to femorofemoral bypass.     

Analysis of primary-on-slider type piezoelectric actuator and theapplication to two-degree-of-motion freedom plane actuator

The basic characteristics of a primary-on-slider type piezoelectric actuator were theoretically analyzed, and the relationship between the thrust force and the weight force was clarified, and was verified by the experiments. As a result, when the weight force was imposed on the slider, the thrust force increased, but when too heavy a weight force was applied, the thrust force decreased. Various prototypes of two-degree-of-motion freedom plane ultrasonic piezoelectric actuators were experimentally constructed, and the fundamental characteristics were measured. The vibration mode of actuators was also analyzed by ANSYS, and compared with the experimental results. The characteristics of the plane ultrasonic piezoelectric actuators were obtained similar to the theoretical characteristics. Since the shape of this plane ultrasonic piezoelectric actuator is very simple, it is suitable for applications that complicated motions are required in limited space     

Factors affecting the efficiency of peripheral blood stem cell collection in children treated with chemotherapy and G-CSF

Post-training administration of morphine (0.25, 0.5, or 1 mg/kg) dose-dependently impairs retention of an inhibitory avoidance response in mice. The effects on retention performance induced by the drug appear to be due to an effect on memory consolidation. In fact, they were observed when drugs were given at short, but not long, periods of time after training, i.e., when the memory trace was susceptible to modulation. Moreover, these effects are not to be ascribed to an aversive or a rewarding or nonspecific action of the drugs on retention performance, because the latencies during the retention test of those mice that had not received a footshock during the training were not affected by post-training drug administration. Pretreatment with either selective D1 or D2 dopamine (DA) receptor antagonists SCH 23390 and (-)-sulpiride administered at per se noneffective doses (0.025 and 6 mg/kg, respectively) potentiated the effects of morphine, while either selective D1 or D2 receptor agonists SKF 38393 and LY 171555 at per se noneffective doses (5 and 0.25 mg/kg, respectively) antagonized the effects of the opiate on memory consolidation. No significant differences were evident between the effects of D1 and D2 receptor active compounds, thus suggesting that D1 and D2 receptor types are similarly involved in the effects of morphine on memory consolidation, in agreement with previously reported results. These results are discussed in terms of a possible inverse relationship of endogenous opioid and DA systems in the brain that are involved in memory processes.     

Tablet Coating in an Aqueous System

We have studied about the operation technique of film coating with HPMC, Pharmacoat which is our product name, and show here some data in commercial scale using mainly aqueous system which is expected to be carried out in the near future throughout the world.     

Technology for the control of quality in automated manufacturing

This paper reviews the present status of technology for the quality assurance of products produced by flexible automation parts-manufacturing. Two examples of practical systems that represent typical products (rotational and prismatic work-pieces) are described with particular emphasis on control functions relevant to product quality     

A simple method for measuring wire tension in drift tubes

Measuring the tension of wires in drift tubes after construction is an important procedure because sometimes the wires get loose after soldering. The method described here uses a simple circuit for observing the change in the Lissajous pattern of a wire resonating with an external magnetic field. The vibration of the wire causes a fundamental harmonic component in the current and results in a periodic change of the Lissajous pattern. Measurement of this fundamental harmonic signal provides a precise determination of the resonance frequency and the wire tension.     

Oxygen consumption of single bovine embryos probed by scanning electrochemical microscopy

Oxygen consumption of individual bovine embryos was noninvasively quantified by scanning electrochemical microscopy (SECM). A probe microelectrode was used to scan near a single embryo surface in a culture medium to monitor the oxygen reduction current at 37 degrees C, under a water-saturated atmosphere of 5% CO2 and 95% air. The oxygen concentration profiles near the embryos were in good agreement with the theoretical spherical diffusion. When an embryo reached the stage of a morula with a 74-microm radius on day 6 after in vitro fertilization, the oxygen concentration difference (deltaC) between the bulk solution and the morula surface was 6.90 +/- 1.35 microM. The oxygen consumption rate (F) of the single morula was estimated to be (1.40 +/- 0.27) x 10(-14) mol s(-1). After the SECM measurement, the embryo was continuously cultured for another 2 days and grew to the stage of a blastocyst with a 100-microm radius. For the blastocyst, the deltaC values for the inner cell mass side and the trophoblast side were 16.40 +/- 1.83 and 9.14 +/- 1.68 microM, respectively. The oxygen consumption rate of the blastocyst was found to be in the range of (2.50 +/- 0.46) x 10(-14) mol s(-1) < F < (4.49 +/- 0.50) x 10(-14) mol s(-1). We have carried out SECM measurements for 19 embryos, and the results were compared in detail with these from an optical microscopic observation. The deltaC values for the morulae on day 6 after in vitro fertilization were strongly related to the morphological embryo quality. The morulae showing a larger deltaC value developed into blastocysts of a larger size, and the deltaC value after the subsequent 2 days of cultivation was found to be increased.     

Screening of high melting point phase change materials (PCM) in solar thermal concentrating technology based on CLFR

We have investigated the suitability of high melting point phase change materials for use in new, large scale solar thermal electricity plants. Candidate materials for latent heat thermal energy storage are identified and their operating parameters modeled and analysed. The mathematical characteristics of charging and discharging these storage materials are discussed. Several high melting point, high conductivity materials are shown to be suitable and advantageous for use with solar thermal electricity plants, such as Sydney University’s novel, low cost CLFR and MTSA collector systems, as well as existing parabolic trough and tower technologies.     

Substituent-Induced Supramolecular Aggregates of Edge Functionalized Nanographenes

Precisely controlled molecular assemblies often display intriguing morphologies and/or functions arising from their structures. The application of the concept of the self-assembly for controlling the aggregation of nanographenes (NGs) is challenging. The title NGs are those carrying both long alkyl chains and tris(phenylisoxazolyl)benzene (TPIB) on the edge. The former group secures the affinity of NGs for organic solvents, and the latter group drives the 1D arrangement of NGs through the interactions between the TPIB units. The concentration-dependent and temperature variable ¹H NMR, UV–vis, and PL spectra demonstrate the aggregation of NGs in 1,2-dichloroethane, and the aggregation is controllable by the regulation of the solvent polarity. AFM images give the stacked structures of the NGs, and these aggregates turn out to be network polymeric structures at a high concentration. These observations demonstrate that the synergy of the face-to-face interactions between the surfaces and the interactions between the TPIB units are effective for controlling the self-assembly of the NGs.     

CMAS degradation of ytterbium aluminum garnets

The degradation of ytterbium aluminum garnet (YbAG) exposed to molten Ca–Mg–Fe–Al–Si–O (CMAS) at 1673 K was investigated for two kinds of dense polycrystalline YbAG with compositions deviating slightly from stoichiometry, referred to as Al- and Yb-rich. The mitigation of the CMAS attack for Yb-rich YbAG was markedly superior to that for the Al-rich one. For both types of YbAG, corrosion progressed due to the preferential penetration of the CMAS melt along grain boundaries in the thickness direction and the simultaneous dissolution of crystal grains into the melt. The lower of the corroded region consisted of YbAG crystals with a core/shell-I/shell-II structure. Shell-I contained alkaline earth, silicon, and iron cations, whereas these cations were hardly detected in shell-II. Growth of the shell-I region was considered to progress by dissolution and reprecipitation through the melt existing around it, and finally, the melt disappeared, resulting in the formation of a thin shell-II region containing little of these ions. The formation and growth of the shell-I region were found to be promoted by making the YbAG Yb-rich, resulting in enhancement of the resistance to CMAS.