Lipidomic analysis of fats and oils – a lot more than just omega‐3

Edible oils and fats are among the most abundant cooking ingredients in the world, and are an important part of a healthy balanced diet, especially if they are high in omega‐6 and omega‐3 polyunsaturated fatty acids. Rather than just the total fatty acid compositions, the analysis of individual lipid species within these oils and fats has become increasingly important. Within the past decade several mass spectrometric lipidomics methods have been adapted and applied to the analysis of edible oils and fats. These methodologies are vital for the analysis of a plethora of lipid species that will be important for numerous health and sustainability issues in the future.     

Aeration and gutter water levels in siphonic roof drainage systems

An investigation is presented into how negative system pressures, the degree of aeration, and gutter water levels are affected by the number of outlets in a siphonic roof drainage system. The experimental results show that system pressures decrease if outlets are blocked. It is also shown that the depth of water above an outlet is strongly influenced by the negative pressure acting at the outlet. As the suction effect at the outlet increases, due to lower system pressures, more water and air will be drawn into the outlets and this will result in a corresponding increase in overall gutter water depth. The results also show that there is often built-in redundancy in multiple outlet siphonic systems experiencing lower-intensity rainfall events, and if one or two outlets were blocked, the system would still operate satisfactorily. A new outlet suppressor was trialled and this was shown to reduce gutter water levels by up to 58% at some positions in the gutter.

Il est présenté une enquête sur la manière dont les pressions négatives dans le système concerné, le degré d'aération et les niveaux d'eau dans les chéneaux sont affectés par le nombre d'orifices de sortie dans un système d'écoulement des eaux de toit par siphonnage. Les résultats expérimentaux montrent que les pressions dans le système diminuent si des orifices de sortie sont obturés. Il est également montré que la profondeur de l'eau au-dessus d'un orifice de sortie est fortement influencée par la pression négative s'exerçant à l'orifice de sortie. Plus l'effet de succion à l'orifice de sortie augmente, en raison des pressions plus faibles dans le système, et plus les quantités d'air et d'eau entraînées dans les orifices de sortie seront importantes, et cela aura pour résultat une augmentation correspondante de la profondeur générale de l'eau dans les chéneaux. Les résultats montrent également qu'il existe souvent une redondance intégrée dans les systèmes à siphons comportant des orifices de sortie multiples et soumis à des épisodes pluvieux de faible intensité, et que si un ou deux orifices de sortie sont obturés, le système fonctionne encore de manière satisfaisante. Un nouvel obturateur d'orifice de sortie a été essayé, ce qui a permis de montrer que celui-ci réduit dans une proportion allant jusqu'à 58 % en certains points les niveaux d'eau dans les chéneaux.

Mots clés: aération, niveaux d'eau dans les chéneaux, pressions négatives, écoulement des eaux de toit par siphonnage     

Numerical experience with diagonalization algorithms for asymmetric demand traffic assignment

This paper reviews the concept of a diagonalization algorithm for use in solving traffic network equilibrium problems for which the arc cost and/or the origin-destination travel demand functions are asymmetric. Such functions are known to occur in realistic settings involving multiple modes or users. The computational performance of this algorithm for different degrees of travel demand asymmetry is then explored by a detailed numerical experiment since no previous results of this type have been reported. It is found that, through the use of progressive stopping tolerances, the impact of high degrees of travel demand function asymmetry on the computational burden associated with finding a traffic network equilibrium may be mitigated; in effect equilibrium problems with high degrees of demand asymmetry are little more difficult to solve than perfectly symmetric problems.     

Development of Simplified Heterocyclic Acetogenin Analogues as Potent and Selective Trypanosoma brucei Inhibitors

Neglected tropical diseases caused by parasitic infections are an ongoing and increasing concern. They are a burden to human and animal health, having the most devastating effect on the world′s poorest countries. Building upon our previously reported triazole analogues, in this study we describe the synthesis and biological testing of other novel heterocyclic acetogenin‐inspired derivatives, namely 3,5‐isoxazoles, furoxans, and furazans. Several of these compounds maintain low‐micromolar levels of inhibition against Trypanosoma brucei, whilst having no observable inhibitory effect on mammalian cells, leading to the possibility of novel lead compounds for selective treatment.     

Exploring barriers and opportunities in adopting crowdsourcing based new product development in manufacturing SMEs

Crowdsourcing is an innovative business practice of obtaining needed services, ideas, or content or even funds by soliciting contributions from a large group of people(the ‘Crowd'). The potential benefits of utilizing crowdsourcing in product design are well-documented, but little research exists on what are the barriers and opportunities in adopting crowdsourcing in new product development(NPD) of manufacturing SMEs. In order to answer the above questions, a Proof of Market study is carried out on crowdsourcing-based product design under an Innovate UK funded Smart project, which aims at identifying the needs, challenges and future development opportunities associated with adopting crowdsourcing strategies for NPD. The research findings from this study are reported here and can be used to guide future development of crowdsourcing-based collaborative design methods and tools and provide some practical references for industry to adopt this new and emerging collaborative design method in their business.     

Correlation Between Phytotoxicity on Annual Ryegrass (Lolium rigidum) and Production Dynamics of Allelochemicals Within Root Exudates of an Allelopathic Wheat

An improved allelopathic correlation between phytotoxicity measured in root growth bioassay upon annual ryegrass (Lolium rigidum Gaud.) and the concentrations of a selection of dynamically produced allelochemicals quantified in the root exudates of cv. Khapli wheat (Triticum turgidum ssp. durum (Desf.) Husn.) monitored during the first 15 days of wheat seedling growth in a sterile, agar–water medium, has been established. Changes over the 15-day growth period in the quantities of five exuded benzoxazinones and seven phenolic acids were measured simultaneously using GC/MS/MS. Substantiating pure compound dose–response measurements were conducted over a range of concentrations for the putative allelochemicals within the wheat exudates. One synergism-based proposal using the monitored compounds to explain the observed low-exudate-concentration phytotoxicity was explored, but was found to be experimentally inadequate.     

Filtration in coal liquefaction. Influence of digestion conditions in the filtration of non-hydrogenated coal digests

A series of experiments has been carried out to study the way in which preparation conditions of coal digests influence filtration rate. It was shown that a relation exists between cake resistivity and digestion temperature and time, and therefore good control over digestion conditions is important for rapid filtration. Particular attention must be paid to the design of the reactor to ensure that all the material is given the same heat-treatment. The optimum residence time occurs when repolymerization of the dissolved coal commences.     

Flexibilized Copolyimide Adhesives

Two copolyimides, LARC-STPI and STPI-LARC-2, with flexible backbones were prepared and characterized as adhesives. The processability and adhesive properties were compared to those of a commercially available form of LARC-TPI.

Lap shear specimens were fabricated using adhesive tape prepared from each of the three polymers. Lap shear tests were performed at room temperature, 177°C, and 204°C before and after exposure to water-boil and to thermal aging at 204°C for up to 1000 hours.

The three adhesive systems possess exceptional lap shear strengths at room temperature and elevated temperatures both before and after thermal exposure. LARC-STPI, because of its high glass transition temperature provided high lap shear strengths up to 260°C. After water-boil, LARC-TPI exhibited the highest lap shear strengths at room temperature and 177°C, whereas the LARC-STPI retained a higher percentage of its original strength when tested at 204°C [68% versus 50% (STPI-LARC-2) and 40% (LARC-TPI)].

These flexible thermoplastic copolyimides show considerable potential as adhesives based on this study and because of the ease of preparation with low cost, commercially available materials.