Cross-talk induces bifurcations in nonlinear models of synaptic plasticity

Linear models of synaptic plasticity provide a useful starting-point for examining the dynamics of neuronal development and learning, but their inherent problems are well known. Models of synaptic plasticity that embrace the demands of biological realism are therefore typically nonlinear. Viewed from a more abstract perspective, nonlinear models of synaptic plasticity are a subset of nonlinear dynamical systems. As such, they may therefore exhibit bifurcations under the variation of control parameters, including noise and errors in synaptic updates. One source of noise or error is the cross-talk that occurs during otherwise Hebbian plasticity. Under cross-talk, stimulation of a set of synapses can induce or modify plasticity in adjacent, unstimulated synapses. Here, we analyze two nonlinear models of developmental synaptic plasticity and a model of independent component analysis in the presence of a simple model of cross-talk. We show that cross-talk does indeed induce bifurcations in these models, entirely destroying their ability to acquire either developmentally or learning-related patterns of fixed points. Importantly, the critical level of cross-talk required to induce bifurcations in these models is very sensitive to the statistics of the afferents' activities and the number of afferents synapsing on a postsynaptic cell. In particular, the critical level can be made arbitrarily small. Because bifurcations are inevitable in nonlinear models, our results likely apply to many nonlinear models of synaptic plasticity, although the precise details vary by model. Hence, many nonlinear models of synaptic plasticity are potentially fatally compromised by the toxic influence of cross-talk and other sources of noise and errors more generally. We conclude by arguing that biologically realistic models of synaptic plasticity must be robust against noise-induced bifurcations and that biological systems may have evolved strategies to circumvent their possible dangers.     

电力电子和未来的航海电气系统(上)

明天的航海电气系统将同今天的系统有极大的不同。电力电子给予船舶上包括推进、电力分配、备用电源、声纳和雷达等在内的各种系统的进展以重要的影响。刚刚出现的新材料、新器件和新的系统概念(诸如宽带半导体材料、碳化硅基的电力半导体器件、电力电子模组(PEBB),以及集成功率系统)正在使、并将持续地使未来的航海系统有别于今天的系统,如同内燃船舶有别于蒸汽船舶。但是,这些正在实现的技术和有关概念还未被大家所周知,而且还有难于理解的地方。本文就将介绍这些新概念和新技术,指出潜在的影响力,并揭示新的设计方法,以推动航海电气系统的发展。     

The Nature of Struck-by Accidents

Construction accidents are broadly categorized into five basic groups, namely falls (from elevation), shock (electrical), caught in/between, struck-by, and other. “Struck-by” accidents accounted for 22% of all construction-related fatalities recorded by the Occupational Safety and Health Administration between 1985 and 1989. Recent (1997 to 2000) data show that the percentage of struck-by accidents constituted 24.6% of the fatalities and serious construction worker injuries. Struck-by accidents primarily involve workers struck by equipment, private vehicles, falling materials, vertically hoisted materials, horizontally transported materials, and trench cave ins. Determining possible causation factors of these accident types is often difficult, due to the broad categories utilized in the accident coding system. This study resulted in gaining insights about the root causes of the struck-by injuries. By finding the root causes, effective methods for accident prevention can be developed.     

Health Service Use Predictors Among Trauma Survivors: A Critical Review.

This article had 2 aims: (a) to comprehensively review and synthesize the literature on predictors of health service utilization in survivors of traumatic events and posttraumatic stress disorder (PTSD) patients and (b) to discuss methodological issues in examining service utilization in this population. PsycINFO was searched for relevant articles published through April 2004. Included studies had to primarily sample trauma survivors or PTSD patients and statistically explore health service use determinants. Although some findings conflicted across studies, increased mental health service use was generally related to being female, having a previous trauma history, and having a PTSD diagnosis. Increased medical service use was found among those with a PTSD diagnosis. Methodological recommendations are made for future health service use studies. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Development of a measure for the information technology infrastructure construct

The goal of this research was to operationalize the information technology infrastructure (ITI) concept by identifying its underlying dimensions and establishing a valid and reliable measure for the construct. In order to accomplish this task with the highest degree of certainty, two approaches were sequentially applied: exploratory factor analysis and confirmatory factor analysis. In evaluating the confirmatory factor model, a step-by-step process was employed, assessing unidimensionality, reliability, discriminant validity, and nomological validity. The dimensions of ITI were determined to be: Chief Information Officer, IT Planning, IT Security, Technology Integration, Advisory Committee, Enterprise Model, and Data Administration. Researchers may now make use of this validated ITI measure to conduct investigations of ITI and other organizational measures. Implications of the ITI measure with other organizational initiatives such as electronic commerce and knowledge management are explored.     

Determinants of the Relative Advantage of a Structured SDM During the Adoption Stage of Implementation

This research investigates a new theoretical model for examining the relationships between user perceptions during innovation adoption. We have taken several innovation-related variables and constructed a framework for assessing the ability of a technology to improve worker performance. Prior research has not addressed the appropriate relationship between innovation adoption-related variables as applied to information systems development methodologies (SDM). This study attempts to use innovation-related variables created by Moore and Benbasat (Information Systems Research 2(3) (1991) 192–222) and Davis (MIS Quarterly 13(3) (1989) 319–340) to propose a framework useful by project managers in designing innovations that will successfully support the efforts of technology users. A framework is proposed, tested, and modified in the context of using an SDM to govern large systems development operation. Forty-seven users within a military software development organization were surveyed about their perceptions of a recently implemented structured SDM. A proposed model of innovation adoption perceptions was tested using correlation and partial least squares regression. Findings suggest a model for predicting the perceived relative advantage of SDMs in the adoption stage of their implementation which is useful in designing techniques in the IS development organizational function.     

The Relationship Between Witnessing Parental Conflict During Childhood and Later Psychological Adjustment Among University Students: Disentangling Confounding Risk Factors.

The purpose of the current study was to examine in detail the association between witnessing domestic violence (DV) and long-term psychological adjustment. Important limitations of past research were addressed, including controlling for several associated risk factors. Special attention was paid to whether the perpetrator of the violence was the maternal or paternal figure, as well as to whether the witness to the violence was male or female. Participants completed measures examining DV witnessed, direct child abuse experienced, and current psychopathology. Following screening for physical and sexual abuse, a sample of 351 individuals was selected. Four groups of participants were compared. Results indicated that individuals who had witnessed either physical DV or major psychological DV had higher levels of psychopathology than individuals who reported witnessing minor psychological DV or controls. After controlling for direct psychological abuse experienced, witnessing DV remained a significant predictor of psychopathology for males but not for females. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Identification of Tone Duration, Line Length, and Letter Position: An Experimental Approach to Timing and Working Memory Deficits in Schizophrenia.

Patients with schizophrenia display numerous cognitive deficits, including problems in working memory, time estimation, and absolute identification of stimuli. Research in these fields has traditionally been conducted independently. We examined these cognitive processes using tasks that are structurally similar and that yield rich error data. Relative to healthy control participants (n = 20), patients with schizophrenia (n = 20) were impaired on a duration identification task and a probed-recall memory task but not on a line-length identification task. These findings do not support the notion of a global impairment in absolute identification in schizophrenia. However, the authors suggest that some aspect of temporal information processing is indeed disturbed in schizophrenia. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Optical modes for BiNem® LCDs

Abstract— We report on theoretical simulations and measurements of the optics of BiNem® displays, taking into account not only the luminance at normal incidence, but contrast ratio and color shift over the viewing hemisphere as well. Transmissive and reflective BiNem® modes were optimized differently, emphasizing contrast in transmission and paperlike, white appearance in reflection.