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101.
102.
Raquel Salazar Jeffry Stone Diana Yakowitz Donald Slack 《Canadian Metallurgical Quarterly》2005,131(6):514-524
The Alto Rio Lerma Irrigation District, located in the state of Guanajuato in Mexico, is an agricultural area whose sustainability depends partially upon groundwater withdrawal for crop irrigation. Because of high pumping demands and current land-management practices, groundwater levels have declined severely, resulting in aquifer overdraft. In order to analyze economic, environmental, and water use problems in this region, 12 potential cropping patterns were generated for different groundwater withdrawals using linear programming. Then, simulation of the agricultural system was performed using GLEAMS to estimate the amounts of water, nitrate, and pesticides in both runoff and percolation for each cropping pattern. Pumping costs and an aquifer exploitation coefficient account for the economic and environmental impacts of aquifer overdraft. Finally, the Range of Value Method (multicriteria method) was applied to rank and identify the best cropping pattern. The results show the best alternative for effectively balancing environmental with economic considerations was the farming practice, consisting of land leveling, growing vegetables such as red tomato, and controlled groundwater withdrawals to preserve aquifer sustainability. 相似文献
103.
As part of a programme to investigate the requirements for computer-based detection aids in the NHS breast screening programme,
we have been studying how the work of mammogram reading is done within different screening centres. Our findings show how
various interactional practices have been evolved in order to help maintain readers’ performance within acceptable levels.
In this paper, we investigate one of these in detail, the use of annotations on screening reporting forms, and we consider
their role in managing readers’ performance. Finally, we consider the implications of such practices for the design of computer-based
systems and tools for breast screening. 相似文献
104.
Douglas B. Clark Brian C. Nelson Hsin-Yi Chang Mario Martinez-Garza Kent Slack Cynthia M. D’Angelo 《Computers & Education》2011
This study investigates the potential of a digital game that overlays popular game-play mechanics with formal physics representations and terminology to support explicit learning and exploration of Newtonian mechanics. The analysis compares test data, survey data, and observational data collected during implementations in Taiwan and the United States with students in grades 7–9. Results demonstrate learning on some core disciplinary measures and high levels of learner engagement, indicating the potential benefits of this genre of conceptually-integrated games, but also suggesting that further research and development will be needed to more fully harness this potential. Encouragingly, striking similarities were observed across the two countries in terms of learning and engagement, suggesting that this genre of learning games may prove suitable for engaging students in active exploration of core science concepts across multiple countries. 相似文献
105.
106.
Electro-migration of nitrate in sandy soil 总被引:4,自引:0,他引:4
Migration of nitrate to groundwater has become a serious threat in many agricultural areas. This paper presents the results of experimental laboratory tests studying the nitrate gradient developed in response to an electrical potential. Two systems were tested; the first had no flow (closed system) and the second had flow opposite to the direction of the electrical current. A solution of sodium nitrate in sandy soil was used in both systems. The tests showed that the electro-kinetic process effectively concentrated and retained nitrate close to the anode. The movement of NO(3)(-) through the soil column was significantly influenced by the development of a pH gradient. Statistical analysis was performed to determine best-fit equations relating the nitrate gradient to the electrical input and pH gradient. A simple one-dimensional finite difference model was used to predict the pH gradient developed during the electro-kinetic process. The experimental measurements closely agreed with the predicted spatial and temporal distribution of the nitrate gradient for both closed and open system configurations. 相似文献
107.
Local Mechanical Perturbation Provides an Effective Means to Regulate the Growth and Assembly of Functional Peptide Fibrils 下载免费PDF全文
Arpad Karsai Teri Jo Slack Hamed Malekan Fadi Khoury Wei‐Feng Lin Victoria Tran Daniel Cox Michael Toney Xi Chen Gang‐yu Liu 《Small (Weinheim an der Bergstrasse, Germany)》2016,12(46):6407-6415
Mucin 1 (MUC1) peptide fused with Q11 (MUC1‐Q11) having 35 residues has previously been shown to form amyloid fibrils. Using time‐dependent and high‐resolution atomic force microscopy (AFM) imaging, it is revealed that the formation of individual MUC1‐Q11 fibrils entails nucleation and extension at both ends. This process can be altered by local mechanical perturbations using AFM probes. This work reports two specific perturbations and outcomes. First, by increasing load while maintaining tip‐surface contact, the fibrils are cut during the scan due to shearing. Growth of fibrils occurs at the newly exposed termini, following similar mechanism of the MUC1‐Q11 nucleation growth. As a result, branched fibrils are seen on the surface whose orientation and length can be controlled by the nuclei orientation and reaction time. In contrast to the “one‐time‐cut”, fibrils can be continuously fragmented by modulation at sufficiently high amplitude. As a result, short and highly branched fibrils accumulate and pile on surfaces. Since the fibril formation and assembly of MUC1‐Q11 can be impacted by local mechanical force, this approach offers a nonchemical and label‐free means to control the presentation of MUC1 epitopes, and has promising application in MUC1 fibril‐based immunotherapy. 相似文献
108.
Brown LE Mitchell G Holden J Folkard A Wright N Beharry-Borg N Berry G Brierley B Chapman P Clarke SJ Cotton L Dobson M Dollar E Fletcher M Foster J Hanlon A Hildon S Hiley P Hillis P Hoseason J Johnston K Kay P McDonald A Parrott A Powell A Slack RJ Sleigh A Spray C Tapley K Underhill R Woulds C 《The Science of the total environment》2010,409(2):256-369
Several recent studies have emphasised the need for a more integrated process in which researchers, policy makers and practitioners interact to identify research priorities. This paper discusses such a process with respect to the UK water sector, detailing how questions were developed through inter-disciplinary collaboration using online questionnaires and a stakeholder workshop. The paper details the 94 key questions arising, and provides commentary on their scale and scope. Prioritisation voting divided the nine research themes into three categories: (1) extreme events (primarily flooding), valuing freshwater services, and water supply, treatment and distribution [each > 150/1109 votes]; (2) freshwater pollution and integrated catchment management [100-150 votes] and; (3) freshwater biodiversity, water industry governance, understanding and managing demand and communicating water research [50-100 votes]. The biggest demand was for research to improve understanding of intervention impacts in the water environment, while a need for improved understanding of basic processes was also clearly expressed, particularly with respect to impacts of pollution and aquatic ecosystems. Questions that addressed aspects of appraisal, particularly incorporation of ecological service values into decision making, were also strongly represented. The findings revealed that sustainability has entered the lexicon of the UK water sector, but much remains to be done to embed the concept operationally, with key sustainability issues such as resilience and interaction with related key sectors, such as energy and agriculture, relatively poorly addressed. However, the exercise also revealed that a necessary condition for sustainable development, effective communication between scientists, practitioners and policy makers, already appears to be relatively well established in the UK water sector. 相似文献
109.
110.
Stephan Bose-O'Reilly Gustav Drasch Aloyce Tesha Gabriele Roider Don Appleton 《The Science of the total environment》2010,408(4):796-1000
In 2003 UNIDO (United Nations Industrial Development Organization) conducted an environmental and health assessment in a small-scale mining area in Tanzania. BGS (British Geological Survey) performed the environmental assessment. The Institute of Forensic Medicine - University of Munich performed the health assessment. The results of the medical, neurological and neuro-psychological examination of 180 participants from the affected area of Rwamagasa and 31 controls were analyzed. Urine, blood and hair samples were analyzed to detect the level of mercury body burden. Mercury concentrations in the bio-monitors urine, blood and hair were statistically significantly higher in the exposed population from Rwamagasa compared to the control group from Katoro. Only amalgam burners showed mercury levels above the toxicological threshold limits. A speciation of mercury in hair indicated that mainly elemental mercury vapor contributed to the high body burden of the artisanal miners. 104 amalgam-burners, the most exposed population group, were examined. 25 of these workers were found to be intoxicated. Small-scale mining is a serious health hazard for amalgam burners. Reduction of the exposure is essential to prevent further damage. 相似文献