Early stages of recrystallization in alloys containing complex structure of second phase particles are of considerable practical interest. They were observed for the AA3104 alloy in which large particles occur against the background of randomly distributed dispersoids. The samples were deformed by equal channel angular pressing and then slightly annealed to obtain the state of partial recrystallization. The highly deformed alloy contained a structure of flat grains with the spacing between high-angle grain boundaries ranging from 100 nm to 1 ??m. On annealing, the structure coarsened and got transformed into nearly equiaxed grains by both discontinuous and continuous recrystallization. The nucleation of new grains was observed in statically recrystallized bulk samples using scanning electron microscopy, and during in-situ recrystallization in a transmission electron microscope. Special attention was paid to the nucleation of new grains in areas close to large second phase particles, where a relatively high stored energy was expected to stimulate nucleation. A particular role in the rise of nuclei is attributed to migration of low angle boundaries. During recrystallization at 623 K (350?°C), in most of the observed cases, the growth of grains occurred by coalescence of neighbouring cells and by migration of high-angle grain boundaries. These processes led to nearly equiaxed grains of similar size. Orientation mappings showed that although orientations of new grains were widely scattered, they were not completely random. 相似文献
Motion planning is a fundamental problem in robotics that has motivated research since more than three decades ago. A large variety of algorithms have been proposed to compute feasible motions of multi-body systems in constrained workspaces. In recent years, some of these algorithms have surpassed the frontiers of robotics, finding applications in other domains such as industrial manufacturing, computer animation and computational structural biology. This paper concerns the latter domain, providing a survey on motion planning algorithms applied to molecular modeling and simulation. Both the algorithmic and application sides are discussed, as well as the different issues to be taken into consideration when extending robot motion planning algorithms to deal with molecules. From an algorithmic perspective, the paper gives a general overview of the different extensions to sampling-based motion planners. From the point of view of applications, the survey deals with problems involving protein folding and conformational transitions, as well as protein–ligand interactions. 相似文献
Crack stability is discussed as affected by their presence in statically-indeterminate beams, frames, rings, etc. loaded into the plastic range. The stability of a crack in a section, which has become plastic, is analyzed with the remainder of the structure elastic and with subsequent additional plastic hinges occurring. The reduction of energy absorption characteristics for large deformations is also discussed. The methods of elastic-plastic tearing instability are incorporated to show that in many cases the fully plastic collapse mechanism must occur for complete failure. 相似文献
The South African government has named the transition towards a greener economy one of its priorities. Meanwhile it has developed a new multilevel integrated planning process, and announced a massive public infrastructure investment plan. The converging point of these three dynamics should be the integration of green infrastructure principles into the different plans as the foundation of the green transition. This paper uses a policy integration analytical framework to assess whether this convergence is in fact taking shape. It analyses the level of integration of green infrastructure principles into the different plans and suggests options to move the green infrastructure agenda forward. 相似文献
Ti, TiC, Al and AlN powders were mixed to synthesize Ti2Al(CxNy) (x + y < 1) solid solutions, Ti2AlCx (x < 1) and Ti2AlN‐related end‐members by hot isostatic pressing at 1400°C/80 MPa for 4 h. For the pure carbides, it is demonstrated that single‐phased samples can only be obtained when about 15% of substoichiometry on the carbon site is applied. Such a result likely implies that Ti2AlCx can only exist in a narrow range of carbon composition. Ti2AlN nitride can be synthesized with y = 1. Assuming that vacancy content varies linearly from 0 to 0.15 going from Ti2AlN to Ti2AlC0.85 in the solid solutions, element concentrations have been calculated to synthesize different solid solutions. Thus, it is demonstrated that single‐phased and fully dense Ti2Al(C0.23N0.71), Ti2Al(C0.45N0.45), and Ti2Al(C0.66N0.22) carbonitrides can be synthesized. 相似文献
Using drugs to treat COVID-19 symptoms may induce adverse effects and modify patient outcomes. These adverse events may be further aggravated in obese patients, who often present different illnesses such as metabolic-associated fatty liver disease. In Rennes University Hospital, several drug such as hydroxychloroquine (HCQ) have been used in the clinical trial HARMONICOV to treat COVID-19 patients, including obese patients. The aim of this study is to determine whether HCQ metabolism and hepatotoxicity are worsened in obese patients using an in vivo/in vitro approach. Liquid chromatography high resolution mass spectrometry in combination with untargeted screening and molecular networking were employed to study drug metabolism in vivo (patient’s plasma) and in vitro (HepaRG cells and RPTEC cells). In addition, HepaRG cells model were used to reproduce pathophysiological features of obese patient metabolism, i.e., in the condition of hepatic steatosis. The metabolic signature of HCQ was modified in HepaRG cells cultured under a steatosis condition and a new metabolite was detected (carboxychloroquine). The RPTEC model was found to produce only one metabolite. A higher cytotoxicity of HCQ was observed in HepaRG cells exposed to exogenous fatty acids, while neutral lipid accumulation (steatosis) was further enhanced in these cells. These in vitro data were compared with the biological parameters of 17 COVID-19 patients treated with HCQ included in the HARMONICOV cohort. Overall, our data suggest that steatosis may be a risk factor for altered drug metabolism and possibly toxicity of HCQ. 相似文献
Fusarium graminearum, the main causal agent of Fusarium Head Blight (FHB), is one of the most damaging pathogens in wheat. Because of the complex organization of wheat resistance to FHB, this pathosystem represents a relevant model to elucidate the molecular mechanisms underlying plant susceptibility and to identify their main drivers, the pathogen’s effectors. Although the F. graminearum catalog of effectors has been well characterized at the genome scale, in planta studies are needed to confirm their effective accumulation in host tissues and to identify their role during the infection process. Taking advantage of the genetic variability from both species, a RNAseq-based profiling of gene expression was performed during an infection time course using an aggressive F. graminearum strain facing five wheat cultivars of contrasting susceptibility as well as using three strains of contrasting aggressiveness infecting a single susceptible host. Genes coding for secreted proteins and exhibiting significant expression changes along infection progress were selected to identify the effector gene candidates. During its interaction with the five wheat cultivars, 476 effector genes were expressed by the aggressive strain, among which 91% were found in all the infected hosts. Considering three different strains infecting a single susceptible host, 761 effector genes were identified, among which 90% were systematically expressed in the three strains. We revealed a robust F. graminearum core effectome of 357 genes expressed in all the hosts and by all the strains that exhibited conserved expression patterns over time. Several wheat compartments were predicted to be targeted by these putative effectors including apoplast, nucleus, chloroplast and mitochondria. Taken together, our results shed light on a highly conserved parasite strategy. They led to the identification of reliable key fungal genes putatively involved in wheat susceptibility to F. graminearum, and provided valuable information about their putative targets. 相似文献
Geopolymer-based glass-ceramic matrix composites can be processed at room temperature and a heat treatment below 100°C leads to matrix hardening thanks to the geopolymerization mechanisms. The stabilization of the matrix into glass-ceramics is achieved via a post-curing at high temperature. This paves the way of the utilization of cost-effective liquid composite molding processes, for which all the necessary equipment is already available for processing temperature ranges related to polymer matrix composites, provided that the rheological behavior of the precursor is suitable to conveniently permeate the fibrous preform. The paper describes the thixotropic rheological behavior of a reference suspension at processing temperature (10°C-20°C) and its evolution along aging at −18°C. The changes are interpreted in terms of geopolymerization mechanisms (dissolution and polycondensation) and suspension rheology (predominance of hydrodynamic effects at high shear rate). On this basis, a phenomenological modeling framework, combining two Krieger-Dougherty equations, is proposed to build a relationship between the effective viscosity of the suspension and the phenomena involved during aging (dissolution of aluminosilicate particles) and shearing (microstructure scalar variable). 相似文献
A novel biobased plasticizer made of cardanol is designed for poly(lactide) (PLA). This cardanol‐derived plasticizer, i.e., methoxylated hydroxyethyl cardanol (MeCard), is synthesized through methoxylation of the double bonds on the side chain of cardanol, and characterized by 1H NMR and mass spectrometry. The plasticization effect of MeCard on the molecular structure, morphology, thermal and mechanical properties of PLA is evaluated and compared to that of a commercial cardanol, i.e., hydroxyethyl cardanol (pCard). The plasticization efficiency of MeCard is demonstrated by a substantial decrease of the glass transition temperature and storage modulus together with a significant increase of the elongation at break as compared to neat PLA. Moreover, MeCard exhibits higher plasticization performance than pCard toward PLA. Such behavior is related to a higher miscibility and compatibility between PLA and MeCard thanks to the methoxylation of the double bonds on the side chain of cardanol as shown by SEM micrographs.
This paper presents a generalization to eddy current images of a thresholding method developed for ultrasonic imaging. It is also shown how to improve the thresholding strength through the definition of a cooperation rule between two threshold assessment measures. This rule is also used to reduce time of calculus. These measures are calculated from the image cooccurrence matrix. The aim is to build a thresholding method that gives a threshold value but also an indicator which allows the operator to know if the methodology applies to the processed image. Examples of results are presented. 相似文献