Discriminating age-associated memory impairment from Alzheimer's disease.

The authors attempt to provide a better understanding of the differences between the normal memory decline characteristic of age-associated memory impairment (AAMI) and the pathological decline typical of mild Alzheimer's disease (AD). Batteries of traditional memory tests and computer-simulated everyday-memory tests discriminated between the 2 groups, which were matched on age, gender, and education, with reasonable degrees of accuracy (87.5% and 88.4%, respectively). False positives were the most frequent classification errors when using either battery. These results indicate that it is possible to use ecologically valid memory assessment paradigms without sacrificing discriminant validity. The clinical significance of discriminating mild AD from AAMI is discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Implantable biomedical microsystems for neural prostheses.

In the following article, the technologies to fabricate polyimide-based thin and flexible substrates with monolithically integrated electrode arrays and printed circuit boards (PCB) for hybrid electronic assemblies as well as an assembling technique that connects bare electronic dice with flexible PCBs are presented. The concept of modular, flexible biomedical microsystems as neural prostheses is introduced in general and described in detail in three examples. A cuff electrode with integrated multiplexer circuitry and standard implantable cables represents the combination of microtechnology with precision mechanics; a sieve electrode used as an implant in peripheral nerve regeneration studies demonstrates the next level of integration density but still uses a cable connection; and last, joint effort to fabricate the demonstrator of a vision prosthesis that is completely implantable in the eye with a wireless link for energy supply and data transmission is presented. System design, hybrid assembling technology, and flexible multilayer encapsulation using parylene and silicone rubber are the key components for creating a new generation of neural prostheses for complex and challenging new applications.     

Ground state systematics and collective dipole excitations of spheroidally deformed sodium clusters in a diffuse jellium model

We solve the Kohn-Sham equations self-consistently in the local density approximation for spheroidal sodium clusters in the particle range 8 ≤ Z ≤ 40. We use a smooth fermi-like jellium density to simulate the influence of the ions in the surface region and obtain similar results as Ekardt and Penzar, but slightly different regions of prolate-to-oblate transitions. We present the systematics of potential energy curves with respect to transitions between oblate, prolate and spherical shapes. Shape transitions occur at particle numbers 12/14 (prolate/oblate), 18/20/22 (oblate/spherical/prolate) and 30/32 (prolate/oblate), which are in good agreement with experimental results. The quadrupole and hexadecupole overlap of the electron density with the jellium is investigated, showing a strong hexadecupole dependence for selected clusters. Collective dipole resonances are described in a simple sum rule approach, which reveals a double splitting according to the different resonance frequencies along the principal axes of the spheroid. The systematics of the resonance peaks for the larger clusters with Z ≥ 20 is in good agreement with experimental results.     

Enhancing the brightness of thin-film electroluminescent displaysby improving the emission process

AC thin film electroluminescent (ACTFEL) devices emit light laterally in addition to conventional surface emission. Because of the waveguiding in ACTFEL devices, lateral emission is stronger than surface emission. However, the former is ignored for displays. This note demonstrates that mirrors can be fabricated into substrates to reflect upward the lateral emission, which can then be summed with surface emission for displays. Use of standard silicon and thin film technology has demonstrated that the reflected lateral emission is a factor of three brighter than conventional surface emission. hence the effective efficiency of out-coupling the light has been improved for an ACTFEL device     

Verbesserung des Vakuums in Isoliergefäßen aus Glas

Improving the vacuum would increase the insulation capacity of commercially available glass containers by a factor of about two. To do this, pressures of 10^?4 mbar must be attained. Different approaches were taken to meet this objective. As an alternative to today's commonly practiced sealing method, three possibilities are introduced which eliminate the necessity of pump stub narrowing which causes reduced conductance. Furthermore, depending on the sealing process used, the gases occuring during sealing are either avoided completly or they can at least be reduced by having the chance of exact temperature control resp. by a lower separation temperature. A completly different approach was taken by using Getters, of which a metal hydride on a TiVMn base proved especially suitable. It is activated by heat and can be integrated into the normal production process without any problem. Aside from a shorter pump period, the added advantage here is the containment of the gasses occuring during sealing as well as that of the longterm gasses.     

Rapid analysis of polymer homologues and additives with SFE/SFC-MS coupling

A rapid and easy analysis method for polymers is presented. The method involves sample preparation by SFE, separation of the extracted compounds by SFC and simultaneous quantitative detection by FID, as well as identification of unknowns by MS. The applications illustrate how structural research work and routine polymer analysis can be done with this time saving method.     

The big picture on big holes

Two serious flaws in popular client firewall software have been uncovered in February     

Stability of everyday memory in age-associated memory impairment: A longitudinal study.

Everyday memory performance was examined longitudinally in 2 groups of Ss meeting the diagnostic criteria for age-associated memory impairment (AAMI). One group of 157 participants in a drug trial for reversing memory loss in AAMI was tested over multiple sessions. The other group of 75 persons did not participate in a drug trial and thus was tested only twice. Both groups were retested for longitudinal follow-up about 4 yrs after initial session. Follow-up test performance remained fairly stable relative to initial performance in both groups. The drug study group showed large practice effects during the course of the drug studies, but these effects subsided after the drug studies' end. Implications regarding memory decline in the normal elderly and neuropsychological measurement issues are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)