Fate of the glucose degradation products 3-deoxyglucosone and glyoxal during peritoneal dialysis

Conventional fluids for peritoneal dialysis (PD) contain reactive glucose degradation products (GDPs) as a result of glucose breakdown during heat-sterilization. GDPs in PD fluids (PDFs) have been associated with the progressive alteration of the peritoneal membrane during long-term PD by cytotoxic effects and formation of advanced glycation endproducts (AGEs). In this study, we investigated the possible fate of two characteristic GDPs, 3-deoxyglucosone (3-DG) and glyoxal, during PD. In vivo, 3-DG and glyoxal concentrations, which were analyzed by high-performance liquid chromatography (HPLC), decreased in PDFs by 78% and 88% during 4 h of dwell time. The PDFs were then incubated in vitro in the presence of the most important reaction partners of GDPs in the peritoneal cavity. Neither human peritoneal mesothelial cells, human peritoneal fibroblasts, soluble protein, an insoluble collagen surface, nor components of spent dialysate led to a significant reduction of 3-DG or glyoxal after 6 h. Only after long-term incubation, a noticeable decrease of 3-DG was observed (-37% after three weeks), more likely due to spontaneous degradation reaction than formation of advanced glycation endproducts. These results suggest that in the course of PD, 3-DG, and glyoxal are absorbed into the organism and thus might contribute to the systemic pool of reactive carbonyl compounds.     

3-D analysis of the breakdown localised defects of ACS through a triac study

The reliability tests of triac and ACS^TM present similarities. In this paper, we propose to analyse the origin of the defects observed by using measurements and 3D simulation with the ISE tools. We are interested in the operation of the triac or ACS^TM in quadrant 2. The results presented here relate to the discrete triac only for reasons of confidentiality. Thermal simulation of the triac shows a strong thermal gradient (thermal shock) in the silicon at turn-on. Stresses and strains in the material created micro crackings that increase the temperature until the fusion of silicon (hot spot).     

机床的营销

在市场竞争中获取成功，不仅取决于技术，也取决于持续的市场营销策略及其实施。从客户的层面出发，可以看到世界范围内机床需求的日益增长，而其重点在亚洲，所以DMG公司视其为最重要的市场。     

The LMO1 and LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14)(p15;q11)

The ectopic expression of LMO1 or LMO2 in T cell acute leukaemias resulting from chromosomal translocations t(11;14)(p15;qll) or t(11;14)(p13;q11) respectively in a causal factor in tumorigenesis. LMO1 has been found as a heterodimer with a 46 Kd protein in a T cell line derived from a childhood T-acute leukaemia. This 46 Kd protein is the LIM-binding protein LDB1/NLI. The latter is a phosphoprotein and binds to LMO1 in its phosphorylated state and essentially all the LMO1 and LDB1 protein in the T cell line is part of the complex. Therefore, the LMO1-LDB1 interaction is likely to be involved in tumorigenesis after LMO1 is ectopically expressed following chromosomal translocation in T cells prior to development of acute leukaemias.     

Munich dark matter search

We plan a dark matter search using cryogenic calorimetric detectors with superconducting phase transition thermometers. We discuss such an experiment, compare its estimated sensitivity range with other dark matter searches, and discuss its planned realization.     

在双镶嵌铜互联中O.13微米器件生成用的基于PVD和ALD阻挡层的先进技术

1. Introduction The requirement of minimal bottom coverageand thick sidewall coverage for PVD-based films forlow via resistance and improved stress migration isnot easy to achieve with traditional depositionmethods. Modern I-PVD techniques give high bot-tom coverage, due to the ionized component of thedeposition flux. Sidewall coverage tends to be low,which is mainly due to off-normal deposition fluxand a less than unity sticking coefficient.     

The impacts of power boating and water skiing on lakes and reservoirs

Over the last 30 years, the use of motorised recreational craft on inland waters has increased significantly, and it is likely that this trend will continue. This growing use of rivers, lakes and water storage reservoirs for recreational purposes has led to concerns about increasing anthropological pressures on freshwater environments. As a result, numerous studies focusing on the possible impact of power boats on inland waterbodies have been undertaken since the early 1970s, when attention started to be drawn to environmental impacts associated with this type of recreation. This paper presents an overview of identified and documented physical, chemical and biological impacts as a result of motorised recreational activities on lakes and reservoirs. Relevant literature, including research papers, government reports and bibliographies, was consulted in the preparation of this review. It has become obvious that in the past, biological impacts have been underestimated. Thus, there is a need for further, more focused, research into the impacts on not only freshwater ecosystems but on terrestrial biota surrounding recreational waters.