Contributions of the left and right cerebral hemispheres to line bisection

Thirty-one right-hemisphere lesioned (RHL) patients, 11 left-hemisphere lesioned patients (LHL) and 10 normal controls (NC) bisected lines in three spatial location and four directional cuing conditions. The error direction and error size were analyzed as separate and combined variables. Seventy-seven percent of RHL patients and 45% of LHL patients made abnormally large errors in line bisection. Right-hemisphere lesioned patients were more sensitive to spatial location and directional cuing than NC subjects. In contrast, LHL patients were less sensitive to either condition than NCs. The error direction and error size emerged as dissociable components of line bisection. Right-hemisphere lesioned patients and NC subjects bisected lines consistently to one side of the true center. Left-hemisphere lesioned patients bisected lines equally often on both sides of the true center. Both RHL and LHL patients made larger absolute bisection errors than NC subjects, but the RHL patient's errors were larger than those of the LHL patients. We propose that the greater sensitivity of RHL patients to spatial location and directional cues and the directional consistency of their bisection errors represent contributions of the intact left cerebral hemisphere to line bisection. In contrast, the LHL patient's unrestrained ability to orient to both ends of the line reflects a contribution of the intact right cerebral hemisphere to line bisection. The failure of both groups to accurately bisect lines reflects a common visuospatial processing deficit that is more pronounced following RHLs than LHLs.     

A low-voltage triggering SCR for on-chip ESD protection at outputand input pads

A novel silicon-controlled rectifier (SCR) structure for on-chip protection against electrostatic discharge (ESD) stress at output or input pads is presented. The SCR switches to an ON state at a trigger voltage determined by the gate length of an incorporated nMOS-like structure. Thus, the new SCR can be designed to consistently trigger at a voltage low enough to protect nMOS transistors from ESD. The capability of a protection circuit using the new SCR design is experimentally demonstrated. The tunability of the SCR trigger voltage with reference to the nMOS breakdown voltage is exploited to improve the human body model (HBM) ESD failure threshold of an output buffer from 1500 to 5000 V     

Evolution of federal and state policies for persons with disability in the United States: Efficiency and welfare impacts

This paper focuses on the labor force participation and earnings of the working age disabled in the United States, as they vary by gender, age, and minority status. Expenditure on public and private sector programs targeted to persons with disabilities exceed $100 billion for approximately 8m individuals. Program objectives are to increase employment opportunities among the disabled as well as, provide public assistance through various welfare provisions. This paper argues public policies and public expenditures have favored assistance and short run equity concerns relative to rehabilitation and vocational training, thus providing work disincentives to people with disabilities and undermining their long-term welfare.     

The impact of trench isolation on latch-up immunity in bulknonepitaxial CMOS

Numerical simulations have been used to show that two-dimensional effects can improve the latch-up immunity of deep trench-isolated, bulk, nonepitaxial CMOS. It is observed that the holding voltage is strongly influenced by trench dimensions and layout, which affect the two-dimensional spreading resistance of the conductivity-modulated well and substrate regions, which also changes the parasitic bipolar current gain. To increase the holding voltage, design parameters that are unique to deep trench isolation have been identified. The theoretical understanding that has been obtained can be exploited to design latch-up-free submicrometer CMOS at high packing densities without using expensive epitaxial substrates     

Distribution of IgG subclasses in antimonial unresponsive Indian kala-azar patients

BACKGROUND: Interleukin 10 (IL-10) decreases the severity of experimental acute pancreatitis. The role of endogenous IL-10 in modulating the course of pancreatitis is currently unknown. AIMS: To examine the systemic release of IL-10 and its messenger RNA production in the pancrease, liver, and lungs and analyse the effects of IL-10 neutralisation in caerulein induced acute pancreatitis in mice. METHODS: Acute necrotising pancreatitis was induced by intraperitoneal caerulein. Serum levels of IL-10 and tumour necrosis factor (TNF), and tissue IL-10 and TNF-alpha gene expression were assessed. After injecting control antibody or after blocking the activity of endogenous IL-10 by a specific monoclonal antibody, the severity of acute pancreatitis was assessed in terms of serum enzyme release, histological changes, and systemic and tissue TNF production. RESULTS: In control conditions, serum IL-10 levels increased and correlated with the course of pancreatitis, with a maximal value eight hours after induction. Both IL-10 and TNF-alpha messengers showed a similar course, and were identified in the pancreas, liver, and lungs. Neutralisation of endogenous IL-10 significantly increased the severity of pancreatitis and associated lung injury as well as serum TNF protein levels (+75%) and pancreatic, pulmonary, and hepatic TNF messenger expression (+33%, +29%, +43%, respectively). CONCLUSIONS: In this non-lethal model, systemic release of IL-10 correlates with the course of acute pancreatitis. This anti-inflammatory response parallels the release of TNF and both cytokines are produced multisystemically. Endogenous IL-10 controls TNF-alpha production and plays a protective role in the local and systemic consequences of the disease.     

Flow of materials in rotary kilns used for sponge iron manufacture: Part II. Effect of kiln geometry

The present work identifies the basic features of burden movement in a rotary kiln. The cold model study was conducted with iron ore as the feed material to determine the influence of length to diameter ratio (L/D) of a rotary kiln on the filling degree, hold-up, and residence time of the charge. An empirical equation correlating different operating variables has been derived on the basis of the experimental results. The influence of individual parameters under different conditions on the residence time and back spillage has also been evaluated. Formerly Joint Director, Research and Development, TISCO     

Studies on the contamination of feed molasses for continuous ethanol production in an immobilised yeast cell reactor

With the present world problem of fossil fuel limitations, alcohol production from renewable resources such as sugar cane molasses, particularly by continuous processes, has become important. In continuous processing, feed contamination problems could become critical. A useful inexpensive technique, which can minimise these problems when molasses is used as the substrate, is to ensure that the time period elapsing after dilution of molasses and before feeding to the reactor is minimal. Experiments were conducted to determine how long the clarified molasses feed solution could be kept under non-sterile conditions without affecting the performance of an immobilised whole cell reactor for alcohol production. For this purpose, the fastest growing contaminant (under the prevailing conditions) present in molasses feed solution was isolated by plating technique. From the initial total number of contaminant microorganisms in the feed solution, and from the experimentally determined generation time of the fastest growing contaminant cells, the safe period of storage of diluted molasses was calculated. This value was in reasonable agreement with the experimental observations.     

Chemical brightening of aluminium

The activity details of a Phosbrite-type solution for chemical brightening of aluminium are presented in terms of solvent power, chemical action and electrochemical properties of the solution. The optimum conditions for maximum brightness are discussed. The general consideration of the present analytical approach would enable one to plan a programme for development of a novel chemical brightening solution for a metal if required for economic reason.