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41.
Makoto Ishizaki Tomohito Matsunaga Kuniaki Adachi Eishi Miyashita 《Hemodialysis international. International Symposium on Home Hemodialysis》2004,8(3):219-225
Background: Matrix metalloproteinase‐3 (MMP‐3) has been linked to osteoarticular destruction in rheumatic arthritis. To investigate the role of MMP‐3 in dialysis‐related amyloidosis (DRA), we determined serum MMP‐3 in long‐term hemodialysis (HD) patients with and without clinical manifestations of DRA. Methods: Thirty‐three subjects (63% female, 3% diabetic) enrolled in the study between September 2001 and June 2003. All patients underwent standard HD three times per week, using high‐flux dialyzers. Four patients had active DRA complications (DRA patients), whereas the others (n = 29) had no evidence of DRA. We determined serum concentrations of MMP‐3, C‐reactive protein (CRP), β2‐microglobulin (β2M), and interleukin‐6 (IL‐6). We also studied the effects of hemodiafiltration (HDF) on inflammatory measures by transferring the DRA patients from regular HD to predilution HDF. Results: The DRA group had been on dialysis significantly longer than the control group. Significant positive correlations were observed between MMP‐3 and IL‐6 (R2 = 0.5143, p < 0.0001) and MMP‐3 and CRP (R2 = 0.6492, p < 0.0001). IL‐6 levels increased after a single dialysis treatment, but this effect was minimal with predilution HDF (the increment of IL‐6 levels did not exceed 10 pg/mL). Serum MMP‐3 levels decreased in parallel with the decrease of IL‐6. Conclusions: MMP‐3 serum levels increase in accordance with clinical manifestations of DRA and elevated circulating levels of IL‐6. For the evaluation of the pathophysiologic state of DRA, serum MMP‐3 may be a useful predictor indicative of chronic inflammation and osteoarticular disorders in DRA patients. 相似文献
42.
Michio Tamate Tamiko Sasaki Akio Toba Hiromu Takubo Fernand Pasan Kenji Okamoto 《Electrical Engineering in Japan》2010,171(4):45-52
High‐frequency leakage current that may cause serious conducted EMI problems flows through an inverter system. The paths of the leakage current are stray capacitances that are formed inside of motors, cables, and IGBT modules. This paper proposes a new IGBT module that realizes low conducted emission noise by flipping the IGBT chip of the lower‐voltage side to decrease its stray capacitance. The leakage current flowing through the low‐noise IGBT module becomes small, since the stray capacitance is a main path of the current. Through an experiment, it is clarified that the conducted emission level is reduced by 13 dB at a maximum when the low‐noise IGBT module is applied to a resonant‐type inverter. © 2010 Wiley Periodicals, Inc. Electr Eng Jpn, 171(4): 45–52, 2010; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/eej.20971 相似文献
43.
Hiroyuki Kono Tomohito Ichiki Hideharu Mori Hisayuki Nakatani Minoru Terano 《Polymer International》2001,50(5):568-571
Block copolymerization of propene and 1,5‐hexadiene was carried out by a modified stopped‐flow polymerization method with an MgCl2‐supported Ziegler catalyst. The resulting polymer, polypropene‐block‐poly(methylene‐1,3‐cyclopentane‐co‐propene) (PP‐b‐(PMCP‐co‐PP)), in which the crystallizable PP part was linked with the non‐crystallizable PMCP‐co‐PP part, was characterized by optical microscopy, differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA) and tensile testing. The block copolymer having a chemical linkage between PP and PMCP‐co‐PP showed properties different from those of homopolymer, random copolymer and blend polymer. © 2001 Society of Chemical Industry 相似文献
44.
Takano Yoshihiko Ozawa Tomohito Yoshinaka Masaru Hirota Ken Yamaguchi Osamu 《Journal of Materials Synthesis and Processing》1999,7(2):107-111
Spark plasma sintering (SPS) has been performed for 5 min at 1500°C and 30 MPa using submicrometer-sized Al2O3/ZrO2(2Y) composite powders in the Al2O3-rich region. Dense ZrO2-toughened Al2O3 (ZTA) ceramics show excellent mechanical strength; the strength of 1620 MPa is achieved in the ZTA with 50 mol% ZrO2. The grain size of Al2O3 in ZTA decreases from 1.5 to 0.6 m with increased ZrO2 content. Almost all the ZrO2 grains (0.3 m) are located in the boundaries of the Al2O3 grains. Mechanical properties are discussed, with an emphasis on the relation between t-/m-ZrO2 ratios and microstructures of ZTA. 相似文献
45.
Takahiro Igarashi Tetsuya Nakazawa Chikashi Suzuki Tomohito Tsuru Yoshiyuki Kaji 《Computational Materials Science》2011,50(12):3346-3349
The authors have developed a new approach for large-scale systems including over 100,000 atoms to obtain physical strength from the viewpoint of atom–atom bonding energy. Combining the semi-empirical molecular orbital method with real space division method makes it possible to estimate structural parameters, electronic structures and bonding energy for various large systems. With this method, various quantum physical properties can be obtained quickly using the semi-empirical molecular orbital method, while adopting real space division improves the computational efficiency of parallelization. In this study, the authors applied this method to SiH4 molecule and crystalline silica system, and carried out bond order and bonding energy analyses. In this analysis, the developed method offered almost the same analytical accuracy as the first principle method, while its calculation speed was much faster than that of the latter. The developed method was also suitable for parallel computing. 相似文献
46.
Atsuo Honda Koichiro Tezuka Tomohito Okamura Kaoru Kawamoto Shoji Shimizu Kohei Harada Takahito Tanabe Tatsuya Shirakawa Tomohiro Takahashi 《Electrical Engineering in Japan》2019,206(4):22-35
Osaka Gas Co., Ltd., jointly with NTT DATA Mathematical Systems Inc., has developed unit‐commitment model for optimizing dispatch of power generation units. Main purpose of this development is to simulate the future world of electric power system in accordance with national energy policy aiming to introduce large amount of renewable energy as well as vitalized cross‐border power exchange via PX market to enhance economically‐efficient power system operation. The model incorporates not only constraints of supply‐demand balance but also constraints of operating reserves, regulation reserves, maximum CO2‐emissions, etc. 相似文献
47.
Classification of the degradability of 30 pharmaceuticals in water with ozone, UV and H2O2. 总被引:1,自引:0,他引:1
I H Kim H Tanaka T Iwasaki T Takubo T Morioka Y Kato 《Water science and technology》2008,57(2):195-200
Experiments were conducted to assess the degradability of 30 PPCPs, selected on the basis of consumption and environmental relevance, by O3 process, UV process and AOPs consisting of UV/ H2O2, O3/UV and O3/H2O2. A batch reactor with volume of 22L of water including the PPCPs was used. For UV process, combination of UV and H2O2 or O3 that can generate OH radicals was capable of degrading the PPCPs faster than UV radiation alone. On the other hand, O3 process and O3-based/UV-based AOPs could remove a variety of the PPCPs effectively, while some PPCPs such as 2-QCA, DEET and cyclophosphamide showed a relatively low degradability compared with the other PPCPs. However, further evaluation on formation of intermediate products resulting from the degradation of the parent PPCPs will be needed because DOC concentration was not decreased with lowered concentrations of the PPCPs. 相似文献
48.
I Fukunishi N Kaji T Nakagawa H Nakamura M Kikuchi M Takubo Y Nishihara 《Canadian Metallurgical Quarterly》1996,79(2):555-562
We investigated the psychometric properties of the Japanese version of the 26 item Toronto Alexithymia Scale in a Japanese culture, testing a sample of 1,008. The validity and reliability of this Japanese version were suggested by significant correlations with the Beth Israel Hospital Psychosomatic Questionnaire and estimates to test-retest and internal consistency. These results suggest that this version may be suitable for Japanese populations. Although alexithymia scores were correlated negatively with increasing age, the result, based on the large sample, seems to be of minimal significance. 相似文献
49.
Tomohito Tanaka Kazuto Kawakami Shun-ichi Hayashi 《Journal of Materials Science》2014,49(11):3928-3935
Time of flight secondary ion mass spectrometry (TOF-SIMS) equipped with a high spatial resolution Ga focused ion beam (Ga-FIB) was applied to understand hydrogen diffusion and desorption behavior in duplex stainless steel and Fe–30 % Ni alloys. Deuterium was used as a tracer of hydrogen. Results showed that the secondary ion intensity from body-centered cubic (bcc) and face-centered cubic (fcc) Fe represents the flux of deuterium from the surface and the concentration of deuterium, respectively. The deuterium-depleted zone can be visualized from the interface between bcc and fcc phase to fcc Fe on the surface. Furthermore, direct visualization of the grain boundary diffusion of deuterium is also possible in fcc Fe–30 % Ni alloys, using Ga-FIB-TOF-SIMS. 相似文献
50.
A toxicokinetic study was performed using rats to investigate the possible mechanism of 18 acute deaths in Japanese patients with cancer and herpes zoster by interactions of the new oral antiviral drug, sorivudine (SRV), with one of the oral 5-fluorouracil (5-FU) prodrugs within 40 days after approval of the use of SRV. Tegafur, an anticancer 5-FU prodrug suggested to be used by most of the patients who died, and SRV were orally administered to rats simultaneously once daily. All of these rats died within 10 days, whereas rats given SRV or tegafur alone under the same dosage conditions showed no appreciable change over 20 days compared with controls. In the rats given both drugs, bone marrow and intestinal membrane mucosa were greatly damaged at an early stage of the coadministration, and before death, the animals showed marked decreases in white blood cell and platelet counts, diarrhea with bloody flux, and severe anorexia, as was also manifested by the patients who subsequently died. In the rats given both drugs for 6 days, extremely enhanced 5-FU levels were observed from the first day of administration in plasma and in all tissues examined, including bone marrow and intestines. The extreme enhancement of the tissue 5-FU levels was attributable to the facile inactivation by (E)-5-(2-bromovinyl)uracil (BVU) of hepatic dihydropyrimidine dehydrogenase (DPD), a key enzyme regulating the systemic 5-FU level in the rat and human. BVU, a major metabolite formed from SRV by gut flora, was found at considerable levels in the liver of rats orally administered SRV alone or SRV and tegafur, and there was a marked decrease in hepatic DPD activity. In the presence of NADPH, DPD purified from rat liver cytosol was rapidly and irreversibly inactivated by [14C]BVU as a suicide inhibitor with concomitant incorporation of the radioactivity into the enzyme protein, although SRV showed no inhibitory effect on DPD under the same conditions. Human liver DPD was recently demonstrated by us to be inactivated with BVU in a manner very similar to rat DPD. 相似文献