Bone remodelling after total hip arthroplasty

Bone remodelling of the proximal femur following total hip arthroplasty (THA) is related to stress deviation with respect to physiological condition. The clinical relevance of this process is much debated with respect to its role in THA failure. In the present study a group of 475 An.C.A. anatomic cementless stems implanted in our institution were assumed as clinical reference. Of them, 294 had a short stem and 181 had a long stem. Stress shielding was X-ray evaluated in each patient. The survivorship analysis of this study group (negative events = stress shielding) showed significantly (p<0.05) lower survival rates at 25 months follow-up for patients with long-stem implants. A 3-D FEM model of the proximal femur was used to analyse the load transfer mechanism for the two types of stems in fully or proximally only bonding conditions. Little difference was predicted in the proximal stress magnitudes for the different stem lengths. On the contrary, stem-bone bonding leads to a notable increase in the stress shielding.     

On the impact of physical layer awareness on scheduling and resource allocation in broadband multicellular IEEE 802.16 systems [Radio Resource Management and Protocol Engineering for IEEE 802.16]

Multicellular networks based on the IEEE 802.16 standard appear to be very promising candidates to provide end users with broadband wireless access. However, they also pose interesting challenges in terms of radio resource management, where several design choices are not specified in the standard, intentionally left open to implementors. For this reason, we focus in this article on scheduling and resource allocation, and investigate how they could operate in a cross-layer fashion. In particular, we describe the principles of joint scheduling and resource allocation for IEEE 802.16 operating in AMC mode, and discuss the critical role played by physical layer considerations, especially intercell interference estimation and channel state awareness, in the obtained performance. This leads to identifying key open issues and possible general solutions     

Obituaries: Elizabeth Douvan (1926-2002).

Presents an obituary for Elizabeth Douvan (1926-2002). Douvan was a pioneer in the study of changing gender, work, and family roles; personal values; and well-being in the second half of the 20th century. Through her research, she contributed to the interdisciplinary fields of social psychology and women's studies while building and strengthening institutions that remain committed to the same mission. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Rapid tamoxifen-induced inactivation of an estrogenic response is accompanied by a localized epigenetic modification but not by mutations

Ethidium was found to be efficiently cross-linked to DNA by glyoxal. Kinetic studies showed that the rate of the cross-linking reaction is strongly dependent on the glyoxal concentration. Comparative studies using a series of phenanthridines and acridines showed that NH2 groups at both the 2 and 7 positions on the phenanthridine ring are necessary for efficient cross-linking. Studies using synthetic polydeoxynucleotides showed that the 2-amino group of guanine is absolutely required for cross-linking. Fluorescence contact energy transfer and relative viscosity experiments showed that the cross-linked drug remains intercalated into DNA. DNA gel electrophoresis and melting studies demonstrated that cross-linked ethidium does not dissociate the DNA double helix to single strands.     

Human language technology and communicative disabilities: requirements and possibilities for the future

For some years now, the Nederlandse Taalunie (Dutch Language Union) has been active in promoting the development of human language technology (HLT) applications for speakers of Dutch with communicative disabilities. The reason is that HLT products and services may enable them to improve their communication skills and verbal autonomy. We sought to identify a minimum common set of HLT resources that is required to develop tools for a wide range of communication disabilities. In order to reach this goal, we investigated the specific needs of communicatively disabled people and related these needs to the underlying HLT software components. By analysing the availability and quality of these essential HLT resources, we were able to identify which of the crucial elements need further research and development to become usable for developing applications for communicatively disabled speakers of Dutch. The results obtained in the current survey can be used to inform policy institutions on how they can stimulate the development of HLT resources for this target group. In the current survey results were obtained for Dutch, but a similar approach can also be applied to other languages.     

Quantifying and enforcing robustness in staff rostering

Journal of Scheduling - Employee absences are inevitable in practice due to illness, heavy workloads or accidents. These unforeseen events result in the disruption of employee shift rosters, which...     

METIS-II: low resource machine translation

METIS-II was an EU-FET MT project running from October 2004 to September 2007, which aimed at translating free text input without resorting to parallel corpora. The idea was to use “basic” linguistic tools and representations and to link them with patterns and statistics from the monolingual target-language corpus. The METIS-II project has four partners, translating from their “home” languages Greek, Dutch, German, and Spanish into English. The paper outlines the basic ideas of the project, their implementation, the resources used, and the results obtained. It also gives examples of how METIS-II has continued beyond its lifetime and the original scope of the project. On the basis of the results and experiences obtained, we believe that the approach is promising and offers the potential for development in various directions.     

Abstract argumentation

In this paper we explore the thesis that the role of argumentation in practical reasoning in general and legal reasoning in particular is to justify the use of defeasible rules to derive a conclusion in preference to the use of other defeasible rules to derive a conflicting conclusion. The defeasibility of rules is expressed by means of non-provability claims as additional conditions of the rules.We outline an abstract approach to defeasible reasoning and argumentation which includes many existing formalisms, including default logic, extended logic programming, non-monotonic modal logic and auto-epistemic logic, as special cases. We show, in particular, that the admissibility semantics for all these formalisms has a natural argumentation-theoretic interpretation and proof procedure, which seem to correspond well with informal argumentation.In the admissibility semantics there is only one way for one argument to attack another, namely by undermining one of its non-provability claims. In this paper, we show how other kinds of attack between arguments, specifically how rebuttal and priority attacks, can be reduced to the undermining of non-provability claims.     

Organizational impact of system quality,information quality,and service quality

Increased organizational dependence on information systems drives management attention towards improving information systems’ quality. A recent survey shows that “Improve IT quality” is one of the top concerns facing IT executives. As IT quality is a multidimensional measure, it is important to determine what aspects of IT quality are critical to organizations to help Chief Information Officers (CIOs) to devise effective IT quality improvement strategies. In this research, we model the relationship between information systems’ (IS) quality and organizational impact. We hypothesize greater organizational impact in situations in which system quality, information quality and service quality are high. We also hypothesize a positive relationship between system quality and information quality. We test our hypotheses using survey data. Our structural equation model exhibits a good fit with the observed data. Our results show that IS service quality is the most influential variable in this model (followed by information quality and system quality), thus highlighting the importance of IS service quality for organizational performance. This paper contributes theoretically to IS success models through the system quality-to-information quality and IS quality-to-organizational impact links. Implications of our results for practice and research are discussed.     

Large-scale linear system solver using secondary storage: Self-energy in hybrid nanostructures

We present a Fortran library which can be used to solve large-scale dense linear systems, Ax=b. The library is based on the LU decomposition included in the parallel linear algebra library PLAPACK and on its out-of-core extension POOCLAPACK. The library is complemented with a code which calculates the self-polarization charges and self-energy potential of axially symmetric nanostructures, following an induced charge computation method. Illustrative calculations are provided for hybrid semiconductor–quasi-metal zero-dimensional nanostructures. In these systems, the numerical integration of the self-polarization equations requires using a very fine mesh. This translates into very large and dense linear systems, which we solve for ranks up to 3×¹⁰⁵. It is shown that the self-energy potential on the semiconductor–metal interface has important effects on the electronic wavefunction.

Program summary

Program title: HDSS (Huge Dense System Solver)Catalogue identifier: AEHU_v1_0Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEHU_v1_0.htmlProgram obtainable from: CPC Program Library, Queen's University, Belfast, N. IrelandLicensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.htmlNo. of lines in distributed program, including test data, etc.: 98 889No. of bytes in distributed program, including test data, etc.: 1 009 622Distribution format: tar.gzProgramming language: Fortran 90, CComputer: Parallel architectures: multiprocessors, computer clustersOperating system: Linux/UnixHas the code been vectorized or parallelized?: Yes. 4 processors used in the sample tests; tested from 1 to 288 processorsRAM: 2 GB for the sample tests; tested for up to 80 GBClassification: 7.3External routines: MPI, BLAS, PLAPACK, POOCLAPACK. PLAPACK and POOCLAPACK are included in the distribution file.Nature of problem: Huge scale dense systems of linear equations, Ax=B, beyond standard LAPACK capabilities. Application to calculations of self-energy potential in dielectrically mismatched semiconductor quantum dots.Solution method: The linear systems are solved by means of parallelized routines based on the LU factorization, using efficient secondary storage algorithms when the available main memory is insufficient. The self-energy solver relies on an induced charge computation method. The differential equation is discretized to yield linear systems of equations, which we then solve by calling the HDSS library.Restrictions: Simple precision. For the self-energy solver, axially symmetric systems must be considered.Running time: About 32 minutes to solve a system with approximately 100 000 equations and more than 6000 right-hand side vectors using a four-node commodity cluster with a total of 32 Intel cores.