Effects of a platelet-activating factor antagonist,CV-6209, on Gastric mucosal lesions induced by ischemia-reperfusion

Recent research was shown that oxygen-derived free radicals are involved in the pathogenesis of various diseases, including ischemia-reperfusion injury. We have also reported that oxygen-derived free radicals and lipid peroxidation may play an important role in gastric mucosal injury induced by ischemia-reperfusion. The hypoxanthinexanthine oxidase system and neutrophils are considered important sources of oxygen-derived free radicals in this process. In recent years, it also has been shown that serum platelet-activating factor (PAF) levels increased during ischemia-reperfusion, and that induction of superoxide generation by neutrophils is one of the important biological effects of PAF. In the present study, we examined the effect of CV-6209, a specific PAF receptor antagonist, on gastric mucosal injury induced by ischemia-reperfusion, to shed some light on the possible involvement of PAF in such lesions. CV-6209 significantly attenuated the gastric mucosal injury induced by ischemia-reperfusion, and inhibited both an increase of thiobarbituric acid reactive substances and a decrease of α-tocopherol in gastric mucosa after ischemia-reperfusion. However, CV-6209 had no effect on gastric mucosal blood flow during ischemiano effect on gastric mucosal blood flow during ischemia-reperfusion. These results suggest that endogenous PAF may play an important role in gastric mucosal injury induced by ischemia-reperfusion, and that CV-6209 exerts its beneficial effect mainly by inhibiting neutrophil superoxide production induced by PAF. Based in part on a paper presented at the Third International Conference on Platelet-Activating Factor and Structurally Related Alkyl Ether Lipids, Tokyo, Japan, May 1989.     

Modulation and demodulation techniques in optical heterodyne PSKtransmission systems

Modulation and demodulation techniques are described for an optical PSK heterodyne transmission system operating at 560 Mb/s and 1.2 Gb/s. Performance limitations affecting the receiver sensitivity in a 1.2-Gb/s DPSK system, such as laser phase noise, phase modulation depth, IF center frequency deviation, and local laser power, are studied. High receiver sensitivities for PSK systems were achieved. The applicability of the Mach-Zehnder modulator as a phase modulator for 1.2-Gb/s DPSK is also demonstrated. A 1.2-Gb/s DPSK transmission of over 100 km, using polarization diversity with novel polarization-insensitive automatic frequency control in an attempt to overcome signal fading caused by polarization fluctuation in the transmitting fiber, is also described. A receiver sensitivity of less than -42.8 dBm and varying within 1.4 dB for all states of polarization was achieved. A multichannel high-definition TV (HDTV) transmission experiment using a DPSK polarization-diversity tunable receiver is described     

Phase noise cancellation in a carrier recovered optical heterodynereceiver

The performance and application of an optical heterodyne receiver which uses a carrier recovery demodulator are described. Phase sensitive demodulators used in coherent optical transmission are compared, and the suppression of both phase noise and frequency instability of light sources by a carrier recovery (CR-) demodulator is described. A carrier recovered PSK (CR-PSK) demodulator and a phase noise canceling circuit (PNC) for a coherent SCM receiver are introduced as examples of CR-demodulators. The relationship between laser diode spectral linewidths and the delay time difference between the two paths in the CR-PSK demodulator necessary to keep the system performance within a certain power penalty is then derived. In a preliminary experiment using 560-Mb/s CR-PSK transmission, a receiver sensitivity of -51.6 dBm was obtained, and a laser phase noise suppression of about ¹/₂ that of DPSK was confirmed. The results suggest the possibility of constructing a heterodyne receiver which has no AFC-loop. Applications of a CR-demodulator to an optical frequency division multiplexing (OFDM) system and to a multivalue modulation scheme are discussed     

Double-layered magnetooptic channel waveguide for waveguideisolator application

TE-TM mode conversion based on the nonreciprocal Faraday effect for waveguides fabricated by liquid-phase epitaxially grown (YBiCa)₃Fe₅O₁₂ films is discussed. The phase mismatch is controlled by constructing a double-layer channel waveguide with an intermediate cladding layer of refractive index slightly lower than the core. Care must be taken to compensate any birefringence of materials, e.g. stress- and growth-induced birefringence. It is shown that such a structure is effective in decreasing the effect of waveguide shape deformation on the phase-matching degree. The analysis of the double-layered channel waveguide and experimental results are described     

D-penicillamine-induced myasthenia gravis in a case of eosinophilic fasciitis

During the period 1983-1995, 200 chronic renal failure patients (115 males and 85 females) were parathyroidectomized for hyperparathyroidism in our Department. In all of them, the presenting clinical symptoms, physical signs, biochemical and radiological tests were typically those of hyperparathyroidism. One hundred ninety patients were operated for the first time whereas 10 were re-operated due to relapse of the disease; 3 of these cases were primary hyperparathyroidism, 182 secondary and 5 tertiary. All three primary hyperparathyroidism cases underwent removal of the adenoma; in the group of secondary hyperparathyroidism, 50 underwent removal of all the parathyroid glands found, 25 underwent total parathyroidectomy with forearm or deltoid autograft and 60 subtotal parathyroidectomy whereas in 39 and 8 patients only 3 and 2 parathyroid glands were found respectively. In the group of tertiary hyperparathyroidism, we removed only the hyperplastic gland detected as the operative detection of the rest was not possible. Ten cases were re-operated for removal of the remaining glands. No complications were noted postoperatively, apart from severe hypocalcemia in 20 cases, treated successfully by Calcium and Vitamin D administration. The highest relapse rate was noted among the 8 patients with only the 2 parathyroid glands removed. It seems that total or subtotal parathyroidectomy represents the most successful methods for surgical treatment of hyperparathyroidism complicating chronic renal failure.