Left ventricular diastolic properties of hypertensive patients measured by pulsed tissue Doppler imaging

Examination of left ventricular (LV) diastolic dysfunction in hypertensive patients has been based on parameters obtained from the transmitral flow velocity during pulsed Doppler echocardiography. However, these parameters are affected by loading conditions. We evaluated LV diastolic function along the longitudinal and transverse axes by pulsed tissue Doppler imaging (TDI) in 50 hypertensive (HT) patients and 36 age-matched healthy volunteers (N). Transmitral flow velocity was recorded by pulsed Doppler echocardiography. LV posterior wall motion velocity along the longitudinal and transverse axes also was recorded by pulsed TDI. In both groups, peak early diastolic velocity of the LV posterior wall (Ew) along the transverse axis (N: 15.8+/-5.2 cm/s, HT: 12.2+/-4.4 cm/s) was higher than that along the longitudinal axis (N: 12.7+/-3.1 cm/s, HT: 9.5+/-3.3 cm/s). Peak atrial systolic velocity of the LV posterior wall (Aw) along the longitudinal axis (N: 9.1+/-1.8 cm/s, HT: 9.7 +/-2.6 cm/s) significantly exceeded that along the transverse axis (N: 8.0+/-2.2 cm/s, HT: 8.4+/-2.4 cm/s) in both groups. The Ews were lower and the Aws were higher along both axes in the patient group than in the control group. The time intervals from the aortic component of the second heart sound to the peak of the early diastolic wave (IIA-Ews) along both the transverse (N: 142+/-18 ms, HT: 154+/-19 ms) and longitudinal (N: 151 16 ms, HT: 162+/-20 ms) axes were longer in the patient group. In 29 patients, Ews along both axes correlated negatively (transverse: r = -0.80, P < .0001; longitudinal: r = -0.71, P < .0001) and IIA-Ews correlated positively (transverse: r = 0.81, P < .0001; longitudinal: r = 0.74, P < .001) with the time constant of the LV pressure decay during isovolumic diastole. The Aws along both axes in the 24 patients without pseudonormalization in transmitral flow velocity correlated positively (transverse: r = 0.60, P < .001; longitudinal: r = 0.74, P < .0001) with the LV end-diastolic pressure. In conclusion, LV relaxation and filling along the longitudinal and transverse axes were impaired in many patients with hypertension. Pulsed TDI was useful for evaluating LV diastolic dynamics in this disease.     

Clinically applicable bulk isolation of blood CD34+ cells for autografting in children

The quality of population-based cancer registries has been measured by the indices of the proportion of total incident cases (DCO%) registered by death certificate only (DCO), and the ratio of incidence to mortality (I/D ratio). Recently it has been recommended that DCO% should be used as an index for the reliability of diagnosing cancers and that the proportion of cases first notified via death certificate (DCN, DCN%) be used as an index for the completeness of registration. Parkin introduced a method to estimate the registration rate, the estimated proportion of the "true incidence" that are registered in population-based registries. We recommend a modified method for estimating the registration rate for cancer registries where DCN% is relatively high, as it is in Japan, as Parkin's method may overestimate the registration rate. The method is as follows: the registration rate = (1-DCN% x 1/D ratio)/(1-DCN%). The registration rates at the Osaka Cancer Registry between 1966 and 1992 were estimated using our method. During this period, the yearly registration rate was 74.6-78.4% for males and 69.1-73.3% for females. When the cancer cases were looked at according to site, the yearly registration rate was 74.2-81.6% for stomach cancer, 81.2-89.3% for lung cancer, and 71.3-76.9% for uterine cancer. These results show that the registration rate is high for cancers that have an unfavorable prognosis and low for cancers that have a favorable prognosis. We recommend that all cancer registries in Japan calculate the completeness of registration by utilizing DCN defined as the sum of DCO plus cases not reported as cancer but with supportive clinical information of such obtained through survey of the registry for DCN.     

Propagation properties of longitudinal leaky surface waves on lithium tetraborate

Theoretical and experimental results of longitudinal leaky surface waves with a higher phase velocity than that of ordinary leaky surface waves and a low propagation loss on lithium tetraborate (LBO) are investigated in detail. They propagate along the surface with a phase velocity close to that of longitudinal bulk wave, slightly radiating two kinds of shear bulk waves (or one shear bulk wave in the case that one of two shear wave terms is uncoupled) into the solid. Most surface components of the mode consist of a longitudinal wave term and an electromagnetic wave term. The detailed propagation properties of the longitudinal leaky surface waves on LBO with the Euler angles (phi, theta, 90 degrees ) are investigated theoretically and experimentally. The (011) cut of LBO was found to be desirable for higher frequency SAW devices. One of the reasons why that mode on LBO has a low propagation loss is also discussed.     

Effect of mean stress on fatigue properties of 1800 MPa-class spring steels

Fatigue tests were conducted for 1800 MPa-class spring steels at various stress ratios. For comparison, similar fatigue tests were conducted for conventional steels whose tensile strength was lower than 1200 MPa. The spring steels exhibited fish-eye fractures, and the origins of these fractures were oxide, TiN and the matrix itself. In contrast, the conventional steels never exhibited fish-eye fractures. The fatigue strength of these steels decreased monotonously as the stress ratio increased, when the fatigue strength was evaluated in terms of stress amplitude. However, the fatigue strength degradation was less than that expected from a modified-Goodman line, and the best fit line was obtained by connecting the fatigue limit at zero mean stress to true fracture strength instead of tensile strength. This research also reviewed application of a power low to the stress ratio effect evaluation. In these results, the difference between the spring and conventional steels was negligible.     

Bile Acid–Drug Interaction via Organic Anion-Transporting Polypeptide 4C1 Is a Potential Mechanism of Altered Pharmacokinetics of Renally Excreted Drugs

Patients with liver diseases not only experience the adverse effects of liver-metabolized drugs, but also the unexpected adverse effects of renally excreted drugs. Bile acids alter the expression of renal drug transporters, however, the direct effects of bile acids on drug transport remain unknown. Renal drug transporter organic anion-transporting polypeptide 4C1 (OATP4C1) was reported to be inhibited by chenodeoxycholic acid. Therefore, we predicted that the inhibition of OATP4C1-mediated transport by bile acids might be a potential mechanism for the altered pharmacokinetics of renally excreted drugs. We screened 45 types of bile acids and calculated the IC₅₀, K_i values, and bile acid–drug interaction (BDI) indices of bile acids whose inhibitory effect on OATP4C1 was >50%. From the screening results, lithocholic acid (LCA), glycine-conjugated lithocholic acid (GLCA), and taurine-conjugated lithocholic acid (TLCA) were newly identified as inhibitors of OATP4C1. Since the BDI index of LCA was 0.278, LCA is likely to inhibit OATP4C1-mediated transport in clinical settings. Our findings suggest that dose adjustment of renally excreted drugs may be required in patients with renal failure as well as in patients with hepatic failure. We believe that our findings provide essential information for drug development and safe drug treatment in clinics.     

Cubic GaN/AlGaN Schottky-barrier devices on 3C-SiC substrates

In this work, we focus on the fabrication of cubic GaN based Schottky-barrier devices (SBDs) and measured current voltage (I-V) characteristics and the critical field for electronic breakdown. Phase-pure cubic GaN and c-Al_xGa_1 − xN/GaN structures were grown by plasma assisted molecular beam epitaxy (MBE) on 200 μm thick free-standing 3C-SiC (1 0 0) substrates, which were produced by HOYA Advanced Semiconductor Technologies Co., Ltd. The thickness of the c-GaN and c-Al_0.3Ga_0.7N epilayers were about 600 and 30 nm, respectively. Ni/In Schottky contacts 300 μm in diameter were produced on c-GaN and c-Al_0.3Ga_0.7N/GaN structures by thermal evaporation using contact lithography. A clear rectifying behavior was measured in our SBDs and the I-V behavior was analyzed in detail, indicating the formation of a thin surface barrier at the Ni-GaN interface. Annealing of the Ni Schottky contacts in air at 200 °C reduces the leakage current by three orders of magnitude. The doping density dependence of breakdown voltages derived from the reverse breakdown voltage characteristics of c-GaN SBDs is investigated. The experimental values of breakdown voltage in c-GaN are in good agreement with theoretical values and show the same dependence on doping level as in hexagonal GaN. From our experimental data, we extrapolate a blocking voltage of 600 V in c-GaN films with a doping level N_D = 5 × 10¹⁵ cm⁻³.     

Moving pick‐up‐type contactless power transfer systems and their efficiency using series and parallel resonant capacitors

The equivalent circuit, the efficiency, and the important characteristics of moving pick‐up type contactless power transfer systems are described. If the primary series capacitor and the secondary parallel capacitors are chosen correctly and the winding resistances are ignored, the equivalent circuit of the transformer with these capacitors becomes the same as an ideal transformer at the resonant frequency. This simple approximation helps to understand the phenomena occurring with load changes. Because the circuit analysis becomes simple, the approximate value of the power transfer efficiency can be derived. This paper describes the determination of the capacitor values, the derivation of the equivalent circuit and the efficiency, and test results. © 2010 Wiley Periodicals, Inc. Electr Eng Jpn, 172(2): 47–54, 2010; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/eej.20970     

An integrated numerical simulator for thermal performance assessments of firefighters’ protective clothing

Research and development of firefighters’ protective clothing relies on a large number of fire disaster experiments in order to assess the thermal performance. It would be substantially advantageous to substitute a virtual numerical experiment for a real one in terms of time, cost and safety. The present article reports the development of an integrated numerical simulator that makes possible the estimation of burn injuries originating from fire disasters. In the simulator, a general-purpose computational fluid dynamics program computes the fluid flow and heat transfer in an in situ fire event, while a one-dimensional program calculates the radiative–conductive heat transfer through the clothing and human skin. A data interface combines the two simulations by loose coupling so as to give the real-time burn injury progress output. The predicted surface heat fluxes and burn degrees agree with experimental measurements reasonably well. Possible numerical error sources are discussed that call for potential improvements in the future.     

Preparation and mesostructure control of highly ordered zirconia particles having crystalline walls

Mesostructured zirconia particles having monoclinic-type crystalline walls were prepared using a low-temperature crystallization technique. Crystalline zirconia particles with highly-ordered mesostructures were obtained through the sol–gel process of zirconium sulfate tetrahydrate at 333 K in the presence of molecular self-assemblies of cetyltrimethylammonium bromide (CTAB) or mixtures of CTAB and anionic molecules such as sodium dodecyl sulfate and sodium p-toluenesulfonate. Variations in the molar ratios of CTAB and the chemical species of anionic molecules led to the variations in the periods of highly-ordered zirconia having crystalline walls. Calcination of the mesostructured zirconia particles prepared using templates consisting solely of CTAB yielded crystalline mesoporous zirconia particles.