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STUDY OBJECTIVE: To investigate the effect of Pseudomonas aeruginosa infection on clinical parameters in Chinese patients with noncystic fibrosis and steady-state bronchiectasis. DESIGN: Prospective, cross-sectional clinicomicrobiological study with informed consent. SETTING: Consecutive outpatient recruitment from a specialist bronchiectasis respiratory clinic. PATIENTS: Outpatients (n = 100; 62 women; 55.1+/-16.7 years old; FEV1/FVC 1.4+/-0.7/2.1+/-0.9 L), who had stable respiratory symptoms for more than 3 weeks. MEASUREMENTS AND RESULTS: Respiratory pathogens isolated from the sputum were: Pseudomonas aeruginosa (33), Haemophilus influenzae (10), Moraxella catarrhalis (2), other Gram-negative bacilli (5), Streptococcus pneumoniae (6), Staphylococcus aureus (5), mycobacteria (3), and yeast (1). Clinical parameters in patients with positive isolation of P aeruginosa were compared with those without the organism in the sputum culture (non-P aeruginosa). In the P aeruginosa group, the FEV1/FVC ratio and sputum volume were lower (p < 0.005) and higher (p < 0.0001), respectively, than those of the non-P aeruginosa group. The FEV1/FVC ratio (< 60%) and sputum volume (grading > 5) were independently associated with a positive sputum isolation of P aeruginosa with odds ratios of 3.1 (confidence interval [CI] 1.2 to 8.4; p < 0.01) and 4.7 (CI 1.6 to 13.3; p < 0.001), respectively. CONCLUSIONS: P aeruginosa is the predominant respiratory pathogen isolated in the sputum of Chinese patients with steady-state bronchiectasis, and its isolation is associated with high sputum output (> or = 75th quartile) and moderately severe airflow obstruction (FEV1/FVC < 60%).  相似文献   
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Previous research has established the connection between the way in which children interact with objects and the potential early identification of children with autism. Those findings motivate our own work to develop "smart toys," objects embedded with wireless sensors that are safe and enjoyable for very small children, that allow detailed interaction data to be easily recorded. These sensor-enabled toys provide opportunities for autism research by reducing the effort required to collect and analyze a child’s interactions with objects. In the future, such toys may be a useful part of clinical and in-home assessment tools. In this paper, we discuss the design of a collection of smart toys that can be used to automatically characterize the way in which a child is playing. We use statistical models to provide objective, quantitative measures of object play interactions. We also developed a tool to view rich forms of annotated play data for later analysis. We report the results of recognition experiments on more than fifty play sessions conducted with adults and children as well as discuss the opportunities for using this approach to support video annotation and other applications.  相似文献   
24.
A transient permeation method presented here not only determines the adsorption and diffusion properties of the pores that are the transport pathways through zeolite membranes, but nondestructively estimates the effective thickness of the membrane. Transient responses of the permeate concentration to step changes in the feed were measured on two H-ZSM-5 tubular membranes and modeled assuming Maxwell-Stefan diffusion and Langmuir adsorption. The adsorption isotherms determined from these transient measurements at 298 K of N2 and CO2 were nearly identical to those measured by calorimetry on H-ZSM-5 powders. The CH4 isotherm at 298 K was similar to isotherms measured by calorimetry and gravimetric techniques on Na-ZSM-5 and silicalite powders. The similarity of the isotherms indicates that transport of these light gases occurs mainly through zeolite pores. The Maxwell-Stefan diffusion coefficients DMS depended on concentration and were higher for higher feed partial pressures. Average DMS values for the two membranes were 7.5, 5 and 1.5×10−10 m2/s for N2, CH4, and CO2, respectively; these are in the same range and order as diffusion coefficients measured in zeolite crystals.  相似文献   
25.
Steel–steel ethyl 2-cyanoacrylate adhesive bonds have been thermally aged and the polymeric material isolated from the glue line. Molecular weight measurement by gel permeation chromatography suggest that a significant degree of post-curing occurs followed by a slight decrease in molecular weight. This decrease in molar mass is not considered large enough to explain the observed decrease in bond strength. It is postulated that poly(ethyl 2-cyanoacrylate) undergoes thermal degradation in a manner similar to that reported for poly(methyl methacrylate). The loss in bond strength is thought to be due to the disruption of the polymer–metal interface by monomer molecules produced during the thermal depolymerization.  相似文献   
26.
The classical game theoretic resolutions to Selten’s Chain Store game are unsatisfactory; they either alter the game to avoid the paradox or struggle to organize the existing experimental data. This paper applies co-evolutionary algorithms to the Chain Store game and demonstrates that the resulting system’s dynamics are neither intuitively paradoxical nor contradicted by the existing experimental data. Specifically, some parameterizations of evolutionary algorithms promote genetic drift. Such drift can lead the system to transition among the game’s various Nash Equilibria. This has implications for policy makers as well as for computational modelers.  相似文献   
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Peer-to-Peer (P2P) file sharing attracts much attention due to its scalability and robustness. One important metric in measuring the performance of a P2P file sharing system is the amount of time required for all peers to get the files. We refer this time as the file distribution time. Researchers have proposed protocols to minimize the file distribution time under different situation. However, most works are based on the single-file scenario. On the other hand, there are studies showing that in a file sharing application, users may download multiple files at the same time. In this paper, we analyze the minimum time needed to distribute multiple files. We develop an explicit expression for the minimum amount of time needed to distribute multiple files in a heterogeneous P2P fluid model. Unlike the single-file scenario, we demonstrate that the theoretical lower bound in multi-file is not always achievable. With a comprehensive consideration of all the configurations, we elaborate how to partition the bandwidth capacities of both seeds and leechers for a particular file such that the finish time is optimal.  相似文献   
29.
Fish movement may vary across a wide array of aquatic ecosystems and may be related to the overall size of the system inhabited. We investigated movement of smallmouth bass in Lake Michigan because this information is lacking for larger systems. A total of 16 smallmouth bass were surgically implanted with ultrasonic transmitters within the Beaver Archipelago, northern Lake Michigan. During 2007-2008, a maximum of one location per individual was recorded daily during three specific tracking periods - pre-spawn, spawning, and post-spawn - to determine diurnal movement patterns. Movement was evaluated as site fidelity, minimum displacement rate, maximum excursion rate, and distance from shore. Smallmouth bass exhibited greater maximum excursion rates during the spawn period compared to pre-spawn. Movement rates did not differ between tracking periods; however, movement rates were greater during the spawn period in 2007 than 2008. Both sexes moved further offshore to deeper water during post-spawn, but females were located further offshore than males during this period. Annual site fidelity was more evident during post-spawn than during spawning for both sexes. Two smallmouth bass emigrated outside of the Archipelago, suggesting this population may be more “open” in terms of individuals moving throughout northern Lake Michigan than previously thought. These results indicate smallmouth bass may move greater distances in larger aquatic systems and therefore larger management units (in terms of total area) should be established in Lake Michigan to account for these greater excursion distances.  相似文献   
30.
The covering generalized rough sets are an improvement of traditional rough set model to deal with more complex practical problems which the traditional one cannot handle. It is well known that any generalization of traditional rough set theory should first have practical applied background and two important theoretical issues must be addressed. The first one is to present reasonable definitions of set approximations, and the second one is to develop reasonable algorithms for attributes reduct. The existing covering generalized rough sets, however, mainly pay attention to constructing approximation operators. The ideas of constructing lower approximations are similar but the ideas of constructing upper approximations are different and they all seem to be unreasonable. Furthermore, less effort has been put on the discussion of the applied background and the attributes reduct of covering generalized rough sets. In this paper we concentrate our discussion on the above two issues. We first discuss the applied background of covering generalized rough sets by proposing three kinds of datasets which the traditional rough sets cannot handle and improve the definition of upper approximation for covering generalized rough sets to make it more reasonable than the existing ones. Then we study the attributes reduct with covering generalized rough sets and present an algorithm by using discernibility matrix to compute all the attributes reducts with covering generalized rough sets. With these discussions we can set up a basic foundation of the covering generalized rough set theory and broaden its applications.  相似文献   
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