Analysis of an efficient parallel implementation of active-set Newton algorithm

The Journal of Supercomputing - This paper presents an analysis of an efficient parallel implementation of the active-set Newton algorithm (ASNA), which is used to estimate the nonnegative weights...     

Hybrid knowledge-based tool for mixing equipment selection – the fuzzy neural network

The hybrid knowledge-based system proposed in this paper consists of a “stiff” segment, viz. the expert system based on the object-oriented approach, and a flexible part, viz. the neural network. Some of the input parameters of the problem and output parameters of the “stiff” system are presented as the fuzzy numbers. Detailed information is also presented about the development of the neural network. The most evident advantages of the proposed introduction of a hybrid architecture of the knowledge-based system are a faster evaluation and generation of design alternatives and support of systematic searches and storage of experience. In addition, the resulting ability to extrapolate results would be unattainable with separately acting stiff and flexible systems. A system for the estimation of the parameters of a mixing system for wastewater treatment is presented as an example to illustrate the principles of the hybrid system.     

Role of clozapine in the occurrence of chromosomal abnormalities in human bone-marrow cells in vivo and in cultured lymphocytes in vitro

Bone-marrow chromosomes were examined from 38 mentally and physically retarded and two psychiatric patients who were being treated with a variety of neuropharmacologic drugs. Twenty of these patients used clozapine (Leponex). The clastogenic effects of clozapine in vitro were studied in the lymphocyte cultures of three patients--one free of hematologic disease and two who 6 months earlier had had agranulocytosis attributed to the use of clozapine. The mean frequency of cytogenetic abnormalities in the bone-marrow cells of patients who used clozapine was significantly increased (P less than 0.05). The two patients who had had agranulocytosis had a greater frequency of cytogenetic abnormalities in their cultured lymphocytes in vivo and in vitro than the patient free of hematologic disease. A clone with a 13/14 chromosome translocation was detected in one of the patients. As all patients received a number of drugs during the in vivo and in vitro studies no definite conclusions could be drawn regarding the role played by clozapine in the occurrence of chromosomal abnormalities.     

Label-free detection of amyloid growth with microcantilever sensors

We present an approach for sensing protein aggregation using microcantilever systems. Results?from both single cantilever experiments with internal reference and multicantilever array measurements with dedicated reference cantilevers are discussed. We show that in both?cases protein aggregation on the sensor can be detected through associated changes in surface?stress.     

Significance of tissue anisotropy in optical tomography of the infant brain

We study the effect of tissue anisotropy in optical tomography of neonates. A Monte Carlo method capable of modeling photon migration in an arbitrary 3D tissue model with spatially varying optical properties and tissue anisotropy is used for simulating measurements of neonates. Anatomical and diffusion tensor magnetic resonance imaging of neonates are used for creating the anatomical models. We find that tissue anisotropy affects the measured signal and the pattern of sensitivity in optical measurements.     

Project-based and temporary organizing: Reconnecting and rediscovering

In recent years, the linkages between project management and organization theory have become stronger. In an attempt to address this development, this paper analyzes the research on temporary and project-based organizing. It especially discusses the development associated with the EGOS sub-themes on project organizing and the potential avenues for future research. The paper also summarizes the key findings from the included papers in the special issue on project-based and temporary organizing, which is based on papers from the EGOS conference in 2013. One key argument is that project organizing needs to develop along three lines: new empirical contexts, new theoretical/conceptual issues, and new research methodologies.     

Cross-functional integration for managing customer information flows in a project-based firm

The delivery of integrated solutions calls for effective integration across the functional interfaces of the project-based firm (PBF) throughout the solution's life cycle. We scrutinize cross-functional integration in a triadic setting involving the PBF's sales, project operations, and services functions by focusing on the flow of customer information (information from and about customers) across three functional interfaces. Drawing on a qualitative case study, we develop a categorization consisting of four distinct types of integration mechanisms: meetings, IT systems, personal involvement, and processes and rules. Our results show that in the focal PBF, customer information flows are strongest in the sales–project operations interface and weakest in the sales–services interface. Furthermore, sales and services functions were found to rely predominantly on personal involvement mechanisms in transferring customer information. Our results highlight the need to integrate and manage customer information flows, especially between the sales–services interface, when delivering integrated solutions.