Treatment of skin cancer by means of intersitial curietherapie with artificial radioisotopes and using the after-loading technic

Epidermal septate junctions of Nereis sp. and Cirriformia sp. fixed with OsO4 or glutaraldehyde/OsO4 display variable structure in electron micrographs. In transverse section the septa are often indistinct and obscured by opaque material that fills the junctional cleft. Septa (spaced at 180--280 A) are more clearly defined in slightly oblique transverse section; they exhibit an electron lucent center and appear to be linked by arms. En face views of the junction show a honeycomb pattern. Cytoplasmic faces of junctional membranes are backed with plaques opposite the septa. Lanthanum used as a tracer delineates junctional structure in negative contrast. In transverse section a chain-like lattice is present in the junctional cleft. En face vies show parallel rows of pleated elements often linked by arms into honeycomb arrays. Oblique sections demonstrate that these pleated elements are continuous with the chain-like lattice seen in transverse sections. Lanthanum does not pass entirely through the junction. Lanthanum reveals that the septa have a very intricate substructure, but it is difficult to visualize the architecture that could generate the various images presented by these junctions when seen in different orientations. However, it is clear that these junctions possess some features that are diagnostic of several supposedly different types of septate junctions in invertebrates.     

Study of milk/κ-carrageenan mixtures by atomic force microscopy

Structural characteristics of milk components and milk/κ-carrageenan mixtures were studied by atomic force microscopy (AFM). Samples were adsorbed on highly ordered pyrolytic graphite (HOPG) and mica substrates. Sample attachment by physisorption and imaging in air by AFM resulted in a very promising technique to investigate structures and interactions between biological macromolecules under “near-native” conditions. Differences in adsorption of casein micelles on HOPG and mica surfaces were observed. Casein micelles were adsorbed satisfactorily on HOPG while poor adsorption was obtained on mica surface. Topographical images of casein micelles adsorbed on HOPG denoted pseudo-spherical structures forming aggregates which were polydisperse in size and shape. In the case of milk/κ-carrageenan mixtures, it was observed that as κ-carrageenan concentration increased, the amount of casein micelles attached on HOPG surface decreased. An opposite behavior was observed when samples were adsorbed on mica. Hydrophobic and hydrophilic interactions between samples and substrates helped in improving the understanding of the interactions between the macromolecules studied. Our findings agreed with previous studies suggesting a surface level interaction between casein micelles and κ-carrageenan, the structures observed being dependent on polysaccharide concentration. It can also be concluded that mica may be a suitable substrate for imaging milk/κ-carrageenan mixtures.     

Thermal Decomposition of Diammonium Tetrachloroplatinate to form Platinum Nanoparticles and its Application as Electrodes

Pt nanoparticles were obtained via the thermal decomposition of (NH₄)₂[PtCl₄] (diammonium tetrachloroplatinate) by heating from room temperature to 760 °C. The thermal decomposition process was analyzed using thermogravimetric analysis (TGA) and differential thermal analysis (DTA), X-ray thermodiffraction and infrared spectroscopy. The size and structure of the platinum particles were analyzed using transmission electron microscopy (TEM). The electrochemical activity of Pt particles was assessed by cyclic voltammetry in 0.5 M H₂SO₄. The TGA and DTA results suggested that the thermal decomposition of the precursor proceeded in two stages: loss of NH₄Cl at ~300 °C, followed by loss of NH₄Cl and Cl₂ at ~372 °C. Metallic Pt particles were then produced at temperatures of 372 °C and above. At 760 °C, the mean ± SD size of the Pt particles was (4.1 ± 1.6) nm, as determined from TEM measurements. In cyclic voltammetry (CV) measurements, an electrode comprised of glassy carbon and Pt particles in 0.5 M H₂SO₄ exhibited behavior similar to that observed using a polycrystalline Pt electrode.     

Aluminum nitride for heatspreading in RF IC’s

To reduce the electrothermal instabilities in silicon-on-glass high-frequency bipolar devices, the integration of thin-film aluminum nitride as a heatspreader is studied. The AlN is deposited by reactive sputtering and this material is shown to fulfill all the requirements for actively draining heat from RF IC’s, i.e., it has good process compatibility, sufficiently high thermal conductivity and good electrical isolation also at high frequencies. The residual stress and the piezoelectric character of the material, both of which can be detrimental for the present application, are minimized by a suitable choice of deposition conditions including variable biasing of the substrate in a multistep deposition cycle. Films of AlN as thick as 4 μm are successfully integrated in RF silicon-on-glass bipolar junction transistors that display a reduction of more than 70% in the value of the thermal resistance.     

When is it reasonable to implement the discontinuous sliding‐mode controllers instead of the continuous ones? Frequency domain criteria

Professor Utkin proposed an example showing that the amplitude of chattering caused by the presence of parasitic dynamics (stable actuators) in some systems governed by the First‐Order Sliding‐Mode Controller is lower than that produced by the Super‐Twisting Algorithm. This example served to motivate this paper reconsidering the problem of comparison of chattering in systems with stable actuators, and driven by Discontinuous Sliding‐Mode Controllers (DSMCs) and Continuous Sliding‐Mode Controllers (CSMCs). Comparison of chattering produced by DSMC and CSMC taking into account their amplitudes, frequencies, and average power (AP) needed to maintain the system into real‐sliding modes, allowing to conclude the following: (i) for systems with slow actuators, the amplitude of oscillations and AP produced by DSMC be smaller than those caused by CSMC; (ii) for bounded disturbances with fixed Lipschitz constant, there exist sufficiently fast actuators for which the amplitude of oscillations and AP produced by CSMC be smaller than those caused by DSMC.     

Processes and measurement of knowledge management in supply chains: an integrative systematic literature review

During the last 10 years, important contributions about knowledge management (KM) issues in supply chain management (SCM) have been published. The current paper aims to build upon previous literature reviews focused on KM in supply chains (SCs) from an integrative perspective, particularly recognising the studies conducted by Bhosale and Kant (2016. “Metadata Analysis of Knowledge Management in Supply Chain: Investigating the Past and Predicting the Future.” Business Process Management Journal 22 (1): 140–172) and Cerchione and Esposito (2016. “A Systematic Review of Supply Chain Knowledge Management Research: State of the Art and Research Opportunities.” International Journal of Production Economics 182: 276–292) as an effort to discuss the evolution of KM in the SC field. To this end, a systematic literature review including 210 papers is conducted over the period 2008–2017 from three positions previously not addressed jointly within the supply chain (SC) context: research methods employed by the authors; KM processes applied in the business processes across the SC; and intra and inter- organisational performance metrics linked with KM initiatives. Results exhibited that: (i) ‘Survey’ and ‘Case study’ are the two research methodologies mostly employed by authors (ii) the knowledge transfer is discussed in the majority of the studies reviewed, (iii) 114 intra and inter-organisational performance metrics are reported within the SC context from an empirical data approach. Findings concerning previous identified gap analysis and future lines of research are described.     

In vitro activity of resorcinarene–chlorambucil conjugates for therapy in human chronic myelogenous leukemia cells

A possible way of improving the activity and selectivity profile of antitumor agents is to design drug carrier systems employing soluble macromolecules. Thus, four resorcinarene-PAMAM-dendrimer conjugates of chlorambucil with different groups in the lower part of the macrocycle and different length dendritic arms showed a good stability of the chemical link between drug and spacer. Evaluation of the cytotoxicity of the resorcinarene-PAMAM-dendrimer–chlorambucil conjugate employing a sulforhodamine B (SRB) assay in K-562 (human chronic myelogenous leukemia cells) demonstrated that the conjugate was more potent as an antiproliferative agent than chlorambucil.