曲线锯——提高木材加工能力的新技术

歪斜地锯木材——一定是弄错了。其实不然。现在,先进的锯机能做到精确地锯出弧形,尽可能避免浪费材料。每根木头的最佳切削位置都经过数学计算。REXROTH公司的电动液压驱动装置能引导锯片运动,实时调整,精确地进行曲线切割。     

Evaluating the Suitability of 3D Bioprinted Samples for Experimental Radiotherapy: A Pilot Study

Radiotherapy is an important component in the treatment of lung cancer, one of the most common cancers worldwide, frequently resulting in death within only a few years of diagnosis. In order to evaluate new therapeutic approaches and compare their efficiency with regard to tumour control at a pre-clinical stage, it is important to develop standardized samples which can serve as inter-institutional outcome controls, independent of differences in local technical parameters or specific techniques. Recent developments in 3D bioprinting techniques could provide a sophisticated solution to this challenge. We have conducted a pilot project to evaluate the suitability of standardized samples generated from 3D printed human lung cancer cells in radiotherapy studies. The samples were irradiated at high dose rates using both broad beam and microbeam techniques. We found the 3D printed constructs to be sufficiently mechanically stable for use in microbeam studies with peak doses up to 400 Gy to test for cytotoxicity, DNA damage, and cancer cell death in vitro. The results of this study show how 3D structures generated from human lung cancer cells in an additive printing process can be used to study the effects of radiotherapy in a standardized manner.     

The Role of G Protein-Coupled Receptor Kinase 6 Regulation in Inflammation and Pain

The G protein-coupled receptor kinase 6 is associated with inflammation and pathological pain. Impairment of GRK6 expression was described in chronic inflammatory diseases such as rheumatoid arthritis and this was shown to be accompanied by an imbalance of downstream signaling pathways. Here, we discuss novel aspects of GRK6 interaction and its impact upon hyperalgesia and inflammatory processes. In this review, we compile important findings concerning GRK6 regulation for a better pathophysiological understanding of the intracellular interaction in the context of inflammation and show clinical implications—for example, the identification of possible therapy goals in the treatment of chronic inflammatory hyperalgesia.     

Bemessung,Anwendung und Qualitätssicherung von Stahlfaserspritzbeton im Tunnelbau

Die Spritzbetonbauweise hat sich im Tunnelbau seit Jahren bewährt. Spritzbeton wird als unbewehrter Beton, in Verbindung mit Bewehrung sowie als Stahlfaserspritzbeton eingesetzt. Bei den meisten Tunnelschalen aus Stahlfaserspritzbeton werden Stahlfasern derzeit nur als konstruktive Bewehrung verwendet. Die Faserzugabe führt zu einer nennenswerten Erhöhung der Bruchenergie und somit zu einer höheren Zähigkeit des sonst spröden Materials und damit zu einer höheren Sicherheit. Stahlfaserspritzbeton kann auch anstelle von Spritzbeton mit statisch erforderlicher Mattenbewehrung eingesetzt werden. Die Bemessung erfolgt dann unter Berücksichtigung der Nachrisszugfestigkeit. Diese kann wie bei Stahlfaserbeton an Biegebalken ermittelt werden, die aus größeren Proben herausgesägt werden. Anhand von verschiedenen Beispielen werden die unterschiedlichen Anwendungen aufgezeigt und die dafür erforderlichen Prüfungen vorgestellt. Design, Execution and Quality Management of Steel Fibre Reinforced Shotcrete in Tunnels The shotcrete method has been proven for tunnel structures since years. Shotcrete can be used unreinforced, in combination with reinforcement meshes and with fibre reinforcement. At the moment most steel fibre shotcrete tunnel liners have non‐structural fibre reinforcement. However, the addition of fibres increases the fracture energy of the material and changes the shotcrete behaviour from brittle to ductile with higher reliability. Steel fibre shotcrete can also replace shotcrete with traditional mesh reinforcement. The verification of steel fibre shotcrete takes the post cracking tensile strength of the material into account. The tensile strength of the cracked fibre concrete can be derived from bending tests on beams cut out of a larger shotcrete sample. This paper presents the different types of executed shotcrete applications in tunnels and the necessary test methods.     

Ionic channel current burst analysis by a machine learning based approach

A new method to analyze single ionic channel current conduction is presented. It is based on an automatic classification by K-means algorithm and on the concept of information entropy. This method is used to study the conductance of multistate ion current jumps induced by tetanus toxin in planar lipid bilayers. A comparison is presented with the widely used Gaussian best fit approach, whose main drawback is the fact that it is based on the manual choice of the base line and of meaningful fragments of current signal. On the contrary, the proposed method is able to automatically process a great amount of information and to remove spurious transitions and multichannels. The number of levels and their amplitudes do not have to be known a priori. In this way the presented method is able to produce a reliable evaluation of the conductance levels and their characteristic parameters in a short time.     

Multiphase chemical kinetics of NO3 radicals reacting with organic aerosol components from biomass burning

Multiphase reactions with nitrate radicals are among the most important chemical aging processes of organic aerosol particles in the atmosphere especially at nighttime. Reactive uptake of NO(3) by organic compounds has been observed in a number of studies, but the pathways of mass transport and chemical reaction remained unclear. Here we apply kinetic flux models to experimental NO(3) exposure studies. The model accounts for gas phase diffusion within a cylindrical flow tube, reversible adsorption of NO(3), surface-bulk exchange, bulk diffusion, and chemical reactions from the gas-condensed phase interface to the bulk. We resolve the relative contributions of surface and bulk reactions to the uptake of NO(3) by levoglucosan and abietic acid, which serve as surrogates and molecular markers of biomass burning aerosol (BBA). Applying the kinetic flux model, we provide the first estimate of the diffusion coefficient of NO(3) in amorphous solid organic matrices (10(-8)-10(-7) cm(2) s(-1)) and show that molecular markers are well-conserved in the bulk of solid BBA particles but undergo rapid degradation upon deliquescence/liquefaction at high relative humidity, indicating that the observed concentrations and subsequent apportionment of the biomass burning source could be significantly underestimated.     

垃圾填埋场覆盖层现场试验及特性评价(英文)

填埋场覆盖系统由不同的土层组成,它们具有不同的性质和功能。覆盖层直接与大气和植被接触,因此土的含水率随季节和天气条件不断变化。冬天,土的饱和度增加。夏天,土的含水率减少,同时土中吸力增加。如果土中吸力达到某个极限值,将出现干缩裂缝。这时,粘土阻隔层的密封功能将受到损害。为了研究粘土覆盖系统的长期性状,我们进行了两个大规模现场试验。本文介绍第一批现场试验结果,包括水流量、土中吸力和温度的变化规律。重点介绍保护层(营养层)厚度对覆盖系统水平衡的影响。     

Advances in test generation for testing software and systems

Among the software quality assurance techniques, testing stands out as one of the most frequently used techniques in practice. Consequently, testing is also widely studied in research. An important aspect in testing that receives much attention is the problem of automated test generation. This introductory paper summarizes the papers selected from the 25th IFIP International Conference on Testing Software and Systems (ICTSS 2013), which all deal with this topic. The field is briefly introduced by pointing out to some of the existing survey articles and relating the selected papers in this issue to each other and to the known body of knowledge.