Escape trajectories are deflected when fish larvae intercept their own C-start wake

Fish larvae may intercept their own wake during sharp turns, which might affect their escape performance. We analysed C-starts of larval zebrafish (Danio rerio, Hamilton, 1822) using a computational fluid dynamics approach that simulates free swimming (swimming trajectory is determined by fluid forces) by coupling hydrodynamics and body dynamics. The simulations show that fish may intercept their own wake when they turn by 100–180°. During stage 1 of a C-start, the fish generates a strong jet at the tail that is shed into the wake. During stage 2, the fish intercepts this wake. Counterfactual simulations showed that wake interception increased the lateral force on the fish and reduced the fish''s turning angle by more than 5°. Wake interception caused no significant acceleration tangential to the trajectory of the fish and did not affect total power output. While experimental and simulation evidence suggests that fish larvae can either undershoot or intercept but not overshoot their wake, our simulations show that larger fish might be able to avoid intercepting their wake by either under- or overshooting. As intercepting its own wake modifies the fish''s escape trajectory, fish should account for this effect when planning their escape route.     

Ice‐Templated Scaffolds with Microridged Pores Direct DRG Neurite Growth

Successful spinal cord repair is thought to be promoted with hierarchically structured scaffolds. These should combine aligned porosity with additional linear features on the micrometer scale to guide axons across multiple length scales. Such scaffolds are generated through the carefully controlled directional solidification of an aqueous biopolymer solution, followed by lyophilization. Under specific freezing conditions this yields a highly regular and aligned lamellar architecture. This architecture exhibits uniform ridges of controlled height and width on the lamellar surface. These ridges run parallel to the pore axis, serving as secondary guidance features. The ridges are capable of linearly aligning 62.4% of chick dorsal root ganglia neurites to within ±10° of the ridge direction. Notably, neurites sprouting perpendicular to the ridge are guided into alignment with these microridged features.     

Is Upregulation of Aquaporin 4-M1 Isoform Responsible for the Loss of Typical Orthogonal Arrays of Particles in Astrocytomas?

The astrocytic endfoot membranes of the healthy blood-brain barrier—contacting the capillary—are covered with a large number of the water channel aquaporin 4 (AQP4). They form orthogonal arrays of particles (OAPs), which consist of AQP4 isoform M1 and M23. Under pathologic conditions, AQP4 is distributed over the whole cell and no or only small OAPs are found. From cell culture experiments, it is known that cells transfected only with AQP4-M1 do not form OAPs or only small ones. We hypothesized that in astrocytomas the situation may be comparable to the in vitro experiments expecting an upregulation of AQP4-M1. Quantitative Real-time PCR (qRT-PCR) of different graded astrocytomas revealed an upregulation of both isoforms AQP4 M1 and M23 in all astrocytomas investigated. In freeze fracture replicas of low-grade malignancy astrocytomas, more OAPs than in high-grade malignancy astrocytomas were found. In vitro, cultured glioma cells did not express AQP4, whereas healthy astrocytes revealed a slight upregulation of both isoforms and only a few OAPs in freeze fracture analysis. Taken together, we found a correlation between the decrease of OAPs and increasing grade of malignancy of astrocytomas but this was not consistent with an upregulation of AQP4-M1 in relation to AQP4 M23.     

Preference-inconsistent recommendations: An effective approach for reducing confirmation bias and stimulating divergent thinking?

The Web is a perfect backdrop for opinion formation as a multitude of different opinions is publicly available. However, the different opinions often remain unexploited: Learners prefer preference-consistent over preference-inconsistent information, a phenomenon called confirmation bias. Two experiments were designed to test whether technologies such as recommender systems can be used to overcome this bias. The role of preference-inconsistent recommendations was explored by comparing their influence to a condition with preference-consistent recommendations and to a control condition without recommendations. In Study 1, preference-inconsistent recommendations led to a reduction of confirmation bias and to a more moderate view of the controversial topic of neuro-enhancement. In Study 2, we found that preference-inconsistent recommendations stimulated balanced recall and divergent thinking. Together these studies showed that preference-inconsistent recommendations are an effective approach for reducing confirmation bias and stimulating divergent thinking. In conclusion, future research and practical implications are discussed.     

<Superscript>1</Superscript>H-NMR Spectroscopy as a New Tool in the Assessment of the Oxidative State in Edible Oils

Within the course of lipid peroxidation, hydroperoxides are formed as primary products. They can be used as analytical markers to assess the deterioration status of oils and fats. Here a new ¹H-NMR assay to determine the hydroperoxide amount in edible oils is presented. We were able to show that the analytical performance of the method is similar to that of the commonly used peroxide value (PV) according to Wheeler. A total of 290 edible oil samples were analyzed using both methods. For some oil varieties considerable discrepancies were found between the results obtained. In the case of black seed and olive oil, two substances could be identified that cause positive (black seed oil) and negative (olive oils) deviations from the theoretical PV expected from the NMR values.     

从集体利益中产生个人利益——共鸣设计方法及其在独立住宅转化为集合住宅中的运用

提出可以增加集合住宅受欢迎度的共鸣设计方法策略,这些策略不仅考虑到建筑本身的一些可能性,同时考虑到在空间和社会环境方面的要求,涵盖了物理的、心理的以及社会的因素;指出这类策略的应用带来了高度的用户接受度并使得适应性建筑在一个长时期内可以保持其价值.阐释在设计方法的帮助下,建筑物被记录和相互比较.