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91.
Front Cover: Photoactivatable Mussel‐Based Underwater Adhesive Proteins by an Expanded Genetic Code (ChemBioChem 18/2017)
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Dr. Matthias Hauf Dr. Florian Richter Tobias Schneider Thomas Faidt Dr. Berta M. Martins Dr. Tobias Baumann Dr. Patrick Durkin Prof. Dr. Holger Dobbek Prof. Dr. Karin Jacobs Prof. Dr. Andreas Möglich Prof. Dr. Nediljko Budisa 《Chembiochem : a European journal of chemical biology》2017,18(18):1771-1771
92.
R. Neveling H. Fujita F.D. SmitT. Adachi G.P.A. BergE.Z. Buthelezi J. CarterJ.L. Conradie M. CouderR.W. Fearick S.V. FörtschD.T. Fourie Y. FujitaJ. Görres K. HatanakaM. Jingo A.M. KrumbholzC.O. Kureba J.P. MiraS.H.T. Murray P. von Neumann-CoselS. O’Brien P. Papka I. PoltoratskaA. Richter E. Sideras-HaddadJ.A. Swartz A. TamiiI.T. Usman J.J. van ZylJ. Mabiala 《Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment》2012,662(1):101
93.
Nils von Preetzmann Philipp Eckmann Adriaan M. H. van der Veen Jianrong Li Markus Richter 《American Institute of Chemical Engineers》2021,67(4):e17128
Exact knowledge of natural gas composition is essential in custody transfer to determine the energy content of the delivery. However, for liquefied natural gas (LNG), a reliable composition determination is difficult. Here, we describe the design of a laboratory-scale reference liquefier that enables the validation and calibration of optical spectroscopy sensors by providing them with a sample of metrologically traceable composition. Hence, it is crucial to avoid fractionation of the sample during liquefaction. This is realized by supercritical liquefaction of a reference gas mixture in conjunction with a special vapor–liquid-equilibrium (VLE) cell. As this is a demanding high-pressure application, low-pressure condensation as liquefaction method was also assessed. Through experimental investigations and VLE calculations, preservation of the composition of the produced liquid sample during condensation was studied. We conclude that under optimized conditions, validation, and calibration measurements of optical sensors can be performed on condensed liquids, which, however, needs further confirmation. 相似文献
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Alexander W. Richter Nathaniel A. Throckmorton Todd B. Walker 《Computational Economics》2014,44(4):445-476
Policy function iteration methods for solving and analyzing dynamic stochastic general equilibrium models are powerful from a theoretical and computational perspective. Despite obvious theoretical appeal, significant startup costs and a reliance on grid-based methods have limited the use of policy function iteration as a solution algorithm. We reduce these costs by providing a user-friendly suite of MATLAB functions that introduce multi-core processing and Fortran via MATLAB’s executable function. Within the class of policy function iteration methods, we advocate using time iteration with linear interpolation. We examine a canonical real business cycle model and a new Keynesian model that features regime switching in policy parameters, Epstein–Zin preferences, and monetary policy that occasionally hits the zero-lower bound on the nominal interest rate to highlight the attractiveness of our methodology. We compare our advocated approach to other familiar iteration and approximation methods, highlighting the tradeoffs between accuracy, speed and robustness. 相似文献
98.
J Wuttke A Budwig M Drochner H Kämmerling FJ Kayser H Kleines V Ossovyi LC Pardo M Prager D Richter GJ Schneider H Schneider S Staringer 《The Review of scientific instruments》2012,83(7):075109
SPHERES is a third-generation neutron backscattering spectrometer, located at the 20 MW German neutron source FRM II and operated by the Ju?lich Centre for Neutron Science. It offers an energy resolution (fwhm) better than 0.65 μeV, a dynamic range of ±?31 μeV, and a signal-to-noise ratio of up to 1750:1. 相似文献
99.
Daniel Stubba Dr. Dennis Bensinger Janika Steinbacher Lilia Proskurjakov Álvaro Salcedo Gómez Dr. Uwe Schmidt Prof. Dr. Stefan Roth Prof. Dr. Katja Schmitz Prof. Dr. Boris Schmidt 《ChemMedChem》2019,14(23):2005-2022
The ubiquitin-proteasome system (UPS) is an established therapeutic target for approved drugs to treat selected hematologic malignancies. While drug discovery targeting the UPS focuses on irreversibly binding epoxyketones and slowly-reversibly binding boronates, optimization of novel covalent-reversibly binding warheads remains largely unattended. We previously reported α-ketoamides to be a promising reversible lead motif, yet the cytotoxic activity required further optimization. This work focuses on the lead optimization of phenoxy-substituted α-ketoamides combining the structure-activity relationships from the primed and the non-primed site of the proteasome β5 subunit. Our optimization strategy is accompanied by molecular modeling, suggesting occupation of P1′ by a 3-phenoxy group to increase β5 inhibition and cytotoxic activity in leukemia cell lines. Key compounds were further profiled for time-dependent inhibition of cellular substrate conversion. Furthermore, the α-ketoamide lead structure 27 does not affect escape response behavior in Danio rerio embryos, in contrast to bortezomib, which suggests increased target specificity. 相似文献
100.
Daniel Ortiz Morales Simon Westerberg Pedro X. La Hera Uwe Mettin Leonid Freidovich Anton S. Shiriaev 《野外机器人技术杂志》2014,31(3):343-363
Working with forestry machines requires a great deal of training to be sufficiently skilled to operate forestry cranes. In view of this, it would be desirable within the forestry industry to introduce automated motions, such as those seen in robotic arms, to shorten the training time and make the work of the operator easier. Motivated by this fact, we have developed two experimental platforms for testing control systems and motion‐planning algorithms in real time. They correspond to a laboratory setup and a commercial version of a hydraulic manipulator used in forwarder machines. The aim of this article is to present the results of this development by providing an overview of our trajectory‐planning algorithm and motion‐control method, with a subsequent view of the experimental results. For motion control, we design feedback controllers that are able to track reference trajectories based on sensor measurements. Likewise, we provide arguments to design controllers in an open‐loop for machines that lack sensing devices. Relying on the tracking efficiency of these controllers, we design time‐efficient reference trajectories of motions that correspond to logging tasks. To demonstrate performance, we provide an overview of extensive testing done on these machines. 相似文献