Dual threshold voltage and sleep switch dual threshold voltage DOIND approach for leakage reduction in domino logic circuits

Subthreshold leakage current becomes the major component of total power dissipation as scaling down the feature size. In this paper, two new circuit techniques are proposed for reducing the subthreshold leakage power consumption in domino logic circuit. Dual threshold voltage DOIND (Domino logic with clock and input dependent transistors) and NMOS sleep switch dual threshold voltage DOIND circuits for low leakage domino logic circuits are presented. High threshold voltage transistors are utilized to reduce the leakage current and a sleep transistor is added to the dynamic node that strongly turnoff all the high threshold voltage transistor and significantly reduce the subthreshold leakage power. The proposed circuit techniques, dual threshold voltage DOIND logic and sleep switch dual threshold voltage DOIND logic reduces the leakage current by 71.46 and 74.86% respectively as compared to standard domino logic circuit. Simulation results also shows that both the circuits are less affected by supply and temperature variations. The proposed sleep switch dual threshold voltage DOIND exhibits 19.95% less power consumption with 24% die area overhead for the buffer circuit as compared to standard domino logic circuit. The proposed sleep switch dual threshold voltage DOIND logic has improved normalized figure of merit of 1.17 as compared to standard domino logic circuit.

     

Pipette-based Method to Study Embryoid Body Formation Derived from Mouse and Human Pluripotent Stem Cells Partially Recapitulating Early Embryonic Development Under Simulated Microgravity Conditions

The in vitro differentiation of pluripotent stem cells partially recapitulates early in vivo embryonic development. More recently, embryonic development under the influence of microgravity has become a primary focus of space life sciences. In order to integrate the technique of pluripotent stem cell differentiation with simulated microgravity approaches, the 2-D clinostat compatible pipette-based method was experimentally investigated and adapted for investigating stem cell differentiation processes under simulated microgravity conditions. In order to keep residual accelerations as low as possible during clinorotation, while also guaranteeing enough material for further analysis, stem cells were exposed in 1-mL pipettes with a diameter of 3.5 mm. The differentiation of mouse and human pluripotent stem cells inside the pipettes resulted in the formation of embryoid bodies at normal gravity (1 g) after 24 h and 3 days. Differentiation of the mouse pluripotent stem cells on a 2-D pipette-clinostat for 3 days also resulted in the formation of embryoid bodies. Interestingly, the expression of myosin heavy chain was downregulated when cultivation was continued for an additional 7 days at normal gravity. This paper describes the techniques for culturing and differentiation of pluripotent stem cells and exposure to simulated microgravity during culturing or differentiation on a 2-D pipette clinostat. The implementation of these methodologies along with -omics technologies will contribute to understand the mechanisms regulating how microgravity influences early embryonic development.     

Building and querying semantic layers for web archives (extended version)

Web archiving is the process of collecting portions of the Web to ensure that the information is preserved for future exploitation. However, despite the in     

Grafting of poly (methyl acrylate) onto sulfite pulp fibers and its effect on water absorbance

To prepare super water absorbent hydrogels of wood cellulose fibers, poly (methyl acrylate) (PMA) was copolymerized onto softwood sulfite pulp fibers using free radical initiator followed by alkaline hydrolysis. Ceric ammonium nitrate (CAN) was used as the free radical initiator. Effects of various parameters such as fiber concentration, monomer/pulp (M/pulp) ratio, CAN concentration, and reaction time on the grafting yield and on other grafting parameters were investigated. The graft conversion was the same from low to medium fiber concentration. The amount of initiator required was found to be independent of fiber concentration to achieve maximum grafting yield. Different fiber fractions (classified based on their length) have no effect on the grafting yield. The evidence of graft copolymerization was determined by using ATR‐IR spectroscopy. The X‐ray diffraction (XRD) analysis shows that grafting takes place both in amorphous and crystalline regions of cellulose fibers and the decrease in crystallinity of the grafted fibers with an increase in grafting yield was confirmed. The surface morphology of the PMA‐g‐cellulose was characterized by scanning electron microscopy (SEM). The water retention value of the hydrolyzed grafted pulp was determined based on a centrifugation technique. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci, 2007     

Computational Modeling of GMAW Process for Joining Dissimilar Aluminum Alloys

A three-dimensional transient model is developed to solve for heat transfer, fluid flow, and species distribution during a continuous gas metal arc welding (GMAW) process for joining dissimilar aluminum alloys. The phase-change process during melting and solidification is modeled using a fixed-grid enthalpy-porositytechnique, and Scheil's model is used to determine coupling among composition, temperature, and the liquid fraction. The effect of molten droplet addition to the weld pool is simulated using a “cavity” model, in which the droplet heat and species addition to the molten pool are considered as volumetric heat and species sources, respectively, distributed in an imaginary cylindrical cavity within the molten pool. To establish the model for joining dissimilar alloys, results for joining two pieces of a similar alloy are also presented. The dissimilar welding model is demonstrated using a case study in which a plate of wrought aluminum alloy (with approximately 0.5 wt% Si) is butt-welded to an aluminum cast alloy plate (with approximately 10 wt% Si) of equal thickness using a GMAW process. Macrosegregation, along with the associated heat transfer and fluid flow phenomena and their role in the weld pool development, are discussed. The model is able to capture some of the key features of the process, such as differential heating of the two alloys, asymmetric weld pool development, mixing of the molten alloys, and the final composition after solidification.     

A Survey on Path Planning Techniques for Mobile Sink in IoT-Enabled Wireless Sensor Networks

Wireless Personal Communications - Recently, the Internet of Things (IoT) had emerged very rapidly and became the most important technology in today’s era. In an IoT-based environment, every...     

Structural Elaboration of a Natural Product: Identification of 3,3′‐Diindolylmethane Aminophosphonate and Urea Derivatives as Potent Anticancer Agents

An approach involving rational structural elaboration of the biologically active natural product diindolylmethane (DIM) with the incorporation of aminophosphonate and urea moieties toward the discovery of potent anticancer agents was considered. A four‐step approach for the synthesis of DIM aminophosphonate and urea derivatives was established. These novel compounds showed potent anticancer activities in two representative kidney and colon cancer cell lines, low toxicity to normal cells, higher potency than the parent natural product DIM and etoposide, and potent inhibition of cancer cell migration. Biophysical and immunological studies, including DAPI nuclear staining, western blot analysis with apoptotic protein markers, flow cytometry, immunocytochemistry, and comet assays of the two most potent compounds revealed good efficacies in apoptosis and DNA damage. It was found that down‐regulation of nuclear factor κB (NF‐κB p65) could be an important mode of action in apoptosis, and the two most potent derivatives were found to be more potent than parent compound DIM in the down‐regulation of NF‐κB. Our results show the importance of structural elaboration of DIM by rational incorporation of aminophosphonate and urea moieties to produce potent anticancer agents; they also suggest that this approach using other structurally simple bioactive natural products as scaffolds holds promise for future drug discovery and development.     

Production of first and second generation biofuels: A comprehensive review

Sustainable economic and industrial growth requires safe, sustainable resources of energy. For the future re-arrangement of a sustainable economy to biological raw materials, completely new approaches in research and development, production, and economy are necessary. The ‘first-generation’ biofuels appear unsustainable because of the potential stress that their production places on food commodities. For organic chemicals and materials these needs to follow a biorefinery model under environmentally sustainable conditions. Where these operate at present, their product range is largely limited to simple materials (i.e. cellulose, ethanol, and biofuels). Second generation biorefineries need to build on the need for sustainable chemical products through modern and proven green chemical technologies such as bioprocessing including pyrolysis, Fisher Tropsch, and other catalytic processes in order to make more complex molecules and materials on which a future sustainable society will be based. This review focus on cost effective technologies and the processes to convert biomass into useful liquid biofuels and bioproducts, with particular focus on some biorefinery concepts based on different feedstocks aiming at the integral utilization of these feedstocks for the production of value added chemicals.     

Covalently linked Au nanoparticles to a viral vector: potential for combined photothermal and gene cancer therapy

Hyperthermia can be produced by near-infrared laser irradiation of gold nanoparticles present in tumors and thus induce tumor cell killing via a bystander effect. To be clinically relevant, however, several problems still need to be resolved. In particular, selective delivery and physical targeting of gold nanoparticles to tumor cells are necessary to improve therapeutic selectivity. Considerable progress has been made with respect to retargeting adenoviral vectors for cancer gene therapy. We therefore hypothesized that covalent coupling of gold nanoparticles to retargeted adenoviral vectors would allow selective delivery of the nanoparticles to tumor cells, thus feasibilizing hyperthermia and gene therapy as a combinatorial therapeutic approach. For this, sulfo-N-hydroxysuccinimide labeled gold nanoparticles were reacted to adenoviral vectors encoding a luciferase reporter gene driven by the cytomegalovirus promoter (AdCMVLuc). We herein demonstrate that covalent coupling could be achieved, while retaining virus infectivity and ability to retarget tumor-associated antigens. These results indicate the possibility of using adenoviral vectors as carriers for gold nanoparticles.