A System-based Paradigm of Drought Analysis for Operational Management

Conventionally droughts are studied in terms of their dimensions (severity, duration and areal extent), without specifying the affected system. The paper presents an innovative system-based approach for drought analysis, which can lead to rational decisions for combating drought. Concepts of water scarcity (drought, water shortage, aridity and desertification) are viewed within the perspective of this new approach. The paper focuses also on operational water management in the presence of drought. Starting from the needs for such management, the affected system is defined and the related quantities are identified. Also, sub-systems are considered which allow the establishment of the link between specific variables and drought. Some drought characterisation methods are particularly suited for the systemic approach. Finally drought is considered as a natural hazard phenomenon and its consequences are discussed. Each physical sub-system can be improved by a variety of measures aiming at decreasing its vulnerability towards drought, so that the drought risk is mitigated. It is concluded that the clear definition of the affected system on the spatial and temporal scales can significantly contribute to the rational management for combating drought.     

High-grade glioma diffusive modeling using statistical tissue information and diffusion tensors extracted from atlases

Glioma, especially glioblastoma, is a leading cause of brain cancer fatality involving highly invasive and neoplastic growth. Diffusive models of glioma growth use variations of the diffusion-reaction equation in order to simulate the invasive patterns of glioma cells by approximating the spatiotemporal change of glioma cell concentration. The most advanced diffusive models take into consideration the heterogeneous velocity of glioma in gray and white matter, by using two different discrete diffusion coefficients in these areas. Moreover, by using diffusion tensor imaging (DTI), they simulate the anisotropic migration of glioma cells, which is facilitated along white fibers, assuming diffusion tensors with different diffusion coefficients along each candidate direction of growth. Our study extends this concept by fully exploiting the proportions of white and gray matter extracted by normal brain atlases, rather than discretizing diffusion coefficients. Moreover, the proportions of white and gray matter, as well as the diffusion tensors, are extracted by the respective atlases; thus, no DTI processing is needed. Finally, we applied this novel glioma growth model on real data and the results indicate that prognostication rates can be improved.     

Regional Drought Assessment Based on the Reconnaissance Drought Index (RDI)

Regional drought assessment is conventionally based on drought indices for the identification of drought intensity, duration and areal extent. In this study, a new index, the Reconnaissance Drought Index (RDI) is proposed together with the well known Standardized Precipitation Index (SPI) and the method of deciles. The new index exhibits significant advantages over the other indices by including apart from precipitation, an additional meteorological parameter, the potential evapotranspiration. The drought assessment is achieved using the above indices in two river basins, namely Mornos and Nestos basins in Greece. It is concluded that although the RDI generally responds in a similar fashion to the SPI (and to a lesser extent to the deciles), it is more sensitive and suitable in cases of a changing environment.     

On-line maximum-order induced hereditary subgraph problems

We first study the competitive ratio for the on‐line version of the problem of finding a maximum‐order induced subgraph satisfying some hereditary property, under the hypothesis that the input graph is revealed by clusters. Next, we focus ourselves on two of the most known instantiations of this problem: the maximum independent set and the maximum clique. Finally, we study a variant of the on‐line maximum‐weight induced hereditary subgraph problem. Our results can also be seen as general reductions, either from off‐line problems to the corresponding on‐line versions, or between on‐line problems. The concept of reduction was absent, until now, from the on‐line computation.     

Problem decomposition in distributed problem-solving systems

Distributed Problem Solving (DPS) is defined as the cooperative solution of problems by a decentralized and loosely coupled collection of problem solvers (agents), each of them knowing how to execute only some of the necessary tasks. This approach considers the problem-solving process as occurring in three phases: problem decomposition, subproblem solution, and answer synthesis. In the problem decomposition phase, one has to determine which tasks will be executed by each agent and when. One of the key research questions in the problem decomposition process is how to decompose a problem in order to minimize the cost of resources needed for its solution. In this article, we construct mathematical programming models in order to describe the decomposition process under the above criterion, study its complexity, and present exact and heuristic algorithms for its solution. Our work was motivated by the operation of an actual system that can be considered as a distributed problem solver for the assessment of irrigation projects design.     

PML Differentially Regulates Growth and Invasion in Brain Cancer

Glioblastoma is the most malignant brain tumor among adults. Despite multimodality treatment, it remains incurable, mainly because of its extensive heterogeneity and infiltration in the brain parenchyma. Recent evidence indicates dysregulation of the expression of the Promyelocytic Leukemia Protein (PML) in primary Glioblastoma samples. PML is implicated in various ways in cancer biology. In the brain, PML participates in the physiological migration of the neural progenitor cells, which have been hypothesized to serve as the cell of origin of Glioblastoma. The role of PML in Glioblastoma progression has recently gained attention due to its controversial effects in overall Glioblastoma evolution. In this work, we studied the role of PML in Glioblastoma pathophysiology using the U87MG cell line. We genetically modified the cells to conditionally overexpress the PML isoform IV and we focused on its dual role in tumor growth and invasive capacity. Furthermore, we targeted a PML action mediator, the Enhancer of Zeste Homolog 2 (EZH2), via the inhibitory drug DZNeP. We present a combined in vitro–in silico approach, that utilizes both 2D and 3D cultures and cancer-predictive computational algorithms, in order to differentiate and interpret the observed biological results. Our overall findings indicate that PML regulates growth and invasion through distinct cellular mechanisms. In particular, PML overexpression suppresses cell proliferation, while it maintains the invasive capacity of the U87MG Glioblastoma cells and, upon inhibition of the PML-EZH2 pathway, the invasion is drastically eliminated. Our in silico simulations suggest that the underlying mechanism of PML-driven Glioblastoma physiology regulates invasion by differential modulation of the cell-to-cell adhesive and diffusive capacity of the cells. Elucidating further the role of PML in Glioblastoma biology could set PML as a potential molecular biomarker of the tumor progression and its mediated pathway as a therapeutic target, aiming at inhibiting cell growth and potentially clonal evolution regarding their proliferative and/or invasive phenotype within the heterogeneous tumor mass.     

A priori optimization for the probabilistic maximum independent set problem

We first propose a formal definition for the concept of probabilistic combinatorial optimization problem (under the a priori method). Next, we study the complexity of optimally solving probabilistic maximum independent set problem under several a priori optimization strategies as well as the complexity of approximating optimal solutions. For the different strategies studied, we present results about the restriction of probabilistic independent set on bipartite graphs.     

Local communities towards a sustainable energy future: needs and priorities

The local authorities demonstrate their willingness to implement sound local sustainable energy policies, especially through their participation in the Covenant of Mayors (CoM). However, in rural environments, namely areas outside of large cities and towns, fulfilling their CoM commitments, especially as regards the local energy planning at the medium- to long-term scale, can come with very different and sometimes challenging constraints. In this context, the main objective of this paper is the assessment of the local communities’ needs and priorities, so as to identify the key parameters that should be taken into consideration during the development of their Sustainable Energy Action Plan. The adopted approach was implemented in rural communities from four countries (Austria, Croatia, Greece and Portugal). From the results obtained, the need for a methodology, appropriately customised to the rural communities’ characteristics, was determined, addressing especially interested stakeholders who are not ‘experts’ in the field.     

Boosted ranking models: a unifying framework for ranking predictions

Ranking is an important functionality in a diverse array of applications, including web search, similarity-based multimedia retrieval, nearest neighbor classification, and recommendation systems. In this paper, we propose a new method, called Boosted Ranking Model (BRM), for learning how to rank from training data. An important feature of the proposed method is that it is domain-independent and can thus be applied to a wide range of ranking domains. The main contribution of the new method is that it reduces the problem of learning how to rank to the much more simple, and well-studied problem of constructing an optimized binary classifier from simple, weak classifiers. Using that reduction, our method constructs an optimized ranking model using multiple simple, easy-to-define ranking models as building blocks. The new method is a unifying framework that includes, as special cases, specific methods that we have proposed in earlier publications for specific ranking applications, such as nearest neighbor retrieval and classification. In this paper, we reformulate those earlier methods as special cases of the proposed BRM method, and we also illustrate a novel application of BRM, on the problem of making movie recommendations to individual users.     

A sparse and spatially constrained generative regression model for fMRI data analysis

In this study, we present an advanced Bayesian framework for the analysis of functional magnetic resonance imaging (fMRI) data that simultaneously employs both spatial and sparse properties. The basic building block of our method is the general linear regression model that constitutes a well-known probabilistic approach. By treating regression coefficients as random variables, we can apply an enhanced Gibbs distribution function that captures spatial constrains and at the same time allows sparse representation of fMRI time series. The proposed scheme is described as a maximum a posteriori approach, where the known expectation maximization algorithm is applied offering closed-form update equations for the model parameters. We have demonstrated that our method produces improved performance and functional activation detection capabilities in both simulated data and real applications.