Physicochemical properties of a dressing-type o/w emulsion as influenced by orange pulp fiber incorporation

A low-in-oil dressing-type o/w emulsion incorporating a rich-in-fiber orange pulp commercial product, either in crude form or following comminution, was prepared and the rheological properties and physicochemical stability of the emulsion were studied. Interactions between the adsorbed at the droplet surfaces yolk proteins and the pulp surface constituents, possibly electrostatic in nature, resulted in extensive droplet aggregation. This was reflected in the dramatic increase of emulsion rheological parameter values, derived by applying the power or the Casson equation to shear stress-rate of shear data. Pulp incorporation resulted in an improvement of emulsion stability against creaming while the stability against droplet coalescence was only marginally affected. In addition, the rheological parameter values of the fortified with pulp emulsion exhibited an appreciable increase with storage, especially in the case of emulsions incorporating the crude pulp. These findings are combined with oil droplet or pulp particle size and ζ-potential data to probe the emulsion structure and explain its behavior during aging.     

VLSI array processors' block implementation of IIR digital filters

VLSI systolic and wavefront array processors' architectures for the block implementation of infinite impulse response digital filters with very high sample rates are presented. The proposed systolic array processor achieves the maximum possible throughput rate and requires only local data transfers. The asynchronous wavefront array processor operates at the same maximum throughput rate and, moreover, it is characterized by a substantial reduced latency. The throughput rate of the proposed array processor structures is a linear function of the block lengthL and theoretically it may be arbitrary high; however, it is limited only by a number of practical implications.     

Legal reasoning methodology: The missing link

The biggest false assumption made when attempting to model automatically acquired legal knowledge is that methodological and procedural legal knowledge is also contained in the text of law. Although the legal profession Intuitively knows the falsity of this assumption, researchers in the area of automatic knowledge acquisition are still confident in implementing systems that use only the text of laws as their main source of knowledge. Knowledge engineers are then forced to make their own interpretations of this knowledge, thus resulting in erroneous and legally unacceptable interpretations of the law. The aim of Nomos (an EC supported project under the ESPRIT II initiative) was to assist the knowledge engineer by providing tools that perform semiautomatic knowledge acquisition from legal texts in Italian and French. This paper uses the implementation of Nomos‐advisor, a legal expert system that uses Nomos's results as an input, as a proof of the falsity of the above assumption and discusses possible solutions.     

Historical queries along multiple lines of time evolution

Traditional approaches to addressing historical queries assume asingle line of time evolution; that is, a system (database, relation) evolves over time through a sequence of transactions. Each transaction always applies to the unique, current state of the system, resulting in a new current state. There are, however, complex applications where the system's state evolves intomultiple lines of evolution. In general, this creates a tree (hierarchy) of evolution lines, where each tree node represents the time evolution of a particular subsystem. Multiple lines create novel historical queries, such asvertical orhorizontal historical queries. The key characteristic of these problems is that portions of the history are shared; answering historical queries should not necessitate duplication of shared histories as this could increase the storage requirements dramatically. Both the vertical and horizontal historical queries have two parts: a search part, where the time of interest is located together with the appropriate subsystem, and a reconstruction part, where the subsystem's state is reconstructed for that time. This article focuses on the search part; several reconstruction methods, designed for single evolution lines can be applied once the appropriate time of interest is located. For both the vertical and the horizontal historical queries, we present algorithms that work without duplicating shared histories. Combinations of the vertical and horizontal queries are possible, and enable searching in both dimensions of the tree of evolutions.     

Assessment of the Efficacy and Clinical Utility of Different Circulating Tumor Cell (CTC) Detection Assays in Patients with Chemotherapy-Naïve Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

We herein investigated the detection frequency and clinical relevance of circulating tumor cells (CTCs) in chemotherapy-naïve stage IIIB/IV non-small cell lung cancer (NSCLC), by using the CellSearch and real-time CEACAM5mRNA assays. Blood samples from 43 patients were obtained at different time points during first-line chemotherapy. CellSearch revealed the detection of ≥1 CTCs in 41.9%, 40.9%, and 16.7% of patients at baseline, post-1st, and post-2nd treatment cycle, respectively, and of ≥5 CTCs in 11.6%, 9.1%, and 5.6%, respectively. CEACAM5mRNA+ CTCs were detected in 29.3% and 16% of patients pre- and post-treatment, respectively. The positivity concordance between the two assays was 2.2%. CTC-detection by CellSearch (≥5 CTCs: p = 0.004), CEACAM5mRNA (p = 0.010), or by any assay (p = 0.000) was associated with disease progression. Reduced survival was demonstrated for patients harboring ≥5 CTCs (progression-free survival; PFS: p = 0.000; overall survival; OS: p = 0.009), CEACAM5mRNA+ CTCs (PFS: p = 0.043; OS: p = 0.039), and CTCs by any assay (PFS: p = 0.005; OS: p = 0.006, respectively). CTC-detection by any assay independently predicted for increased risk of relapse (hazard ratio; HR: 3.496; p = 0.001) and death (HR: 2.866; p = 0.008). CellSearch-positivity either pre-, post-1st, or post-2nd cycle, was predictive for shorter PFS (p = 0.036) compared to negativity in all time points. Persistent CEACAM5mRNA-positivity pre- and post-treatment was associated with reduced PFS (p = 0.036) and OS (p = 0.026). In conclusion, CTC detection and monitoring using the CellSearch and CEACAM5mRNA assays provides valuable and complementary clinical information for chemo-naïve advanced or metastatic NSCLC.     

KnowBaSICS-M: an ontology-based system for semantic management of medical problems and computerised algorithmic solutions

In this paper, an ontology-based system (KnowBaSICS-M) is presented for the semantic management of Medical Computational Problems (MCPs), i.e., medical problems and computerised algorithmic solutions. The system provides an open environment, which: (1) allows clinicians and researchers to retrieve potential algorithmic solutions pertinent to a medical problem and (2) enables incorporation of new MCPs into its underlying Knowledge Base (KB). KnowBaSICS-M is a modular system for MCP acquisition and discovery that relies on an innovative ontology-based model incorporating concepts from the Unified Medical Language System (UMLS). Information retrieval (IR) is based on an ontology-based Vector Space Model (VSM) that estimates the similarity among user-defined MCP search criteria and registered MCP solutions in the KB. The results of a preliminary evaluation and specific examples of use are presented to illustrate the benefits of the system. KnowBaSICS-M constitutes an approach towards the construction of an integrated and manageable MCP repository for the biomedical research community.     

Supporting Temporal Views in a Management Information Base

In many network management applications, likepost-mortem fault analysis or performance trendsprofiling, it is advantageous to have the ability toview the state of the network as it was at some time in the past. To support such Temporal Views anefficient data organization, or access method, is neededfor storing and updating network related data (as thenetwork evolves over time) and for retrieving requested past network states. For applications where thenetwork manager is not interested in the full (and maybetoo large) snapshot of a past network state it is usefulif partial state snapshots can be extracted quickly. It is thus of particular interest toconstruct an access method that can efficiently supportPartial Temporal Views. Efficiency implies that arequested partial temporal view should be constructed directly, without first computing the elaboratefull temporal view. In this paper we present a newaccess method (called the Neighbor History Index) forthis problem. One of the advantages of this method is that the update processing is independent ofthe evolution size (the total number of changes in theevolution). In addition, our method uses a small diskspace overhead. We then present a general framework for organizing time-evolving network data. Ourframework distinguishes between flat and hierarchicalevolutions and subsequently between flat andhierarchical temporal views. We also provide a way toefficiently construct temporal views on hierarchicalevolutions. This paper shows that supporting temporalviews on flat or hierarchical evolutions is notexpensive: our solutions use small space overhead, havesmall updating and compute temporal viewsfast.     

Types and Functions of Mitoribosome-Specific Ribosomal Proteins across Eukaryotes

Mitochondria are key organelles that combine features inherited from their bacterial endosymbiotic ancestor with traits that arose during eukaryote evolution. These energy producing organelles have retained a genome and fully functional gene expression machineries including specific ribosomes. Recent advances in cryo-electron microscopy have enabled the characterization of a fast-growing number of the low abundant membrane-bound mitochondrial ribosomes. Surprisingly, mitoribosomes were found to be extremely diverse both in terms of structure and composition. Still, all of them drastically increased their number of ribosomal proteins. Interestingly, among the more than 130 novel ribosomal proteins identified to date in mitochondria, most of them are composed of a-helices. Many of them belong to the nuclear encoded super family of helical repeat proteins. Here we review the diversity of functions and the mode of action held by the novel mitoribosome proteins and discuss why these proteins that share similar helical folds were independently recruited by mitoribosomes during evolution in independent eukaryote clades.