Applications of wavelet data reduction in a recommender system

Memory-based collaborative filtering (CF) recommender systems have emerged as an effective technique for information filtering. CF recommenders are being widely adopted for e-commerce applications to assist users in finding and selecting items of interest. As a result, the scalability of CF recommenders presents a significant challenge; one that is particularly resilient because the volume of data these systems utilize will continue to increase over time. This paper examines the impact of discrete wavelet transformation (DWT) as an approach to enhance the scalability of memory-based collaborative filtering recommender systems. In particular, a wavelet transformation methodology is proposed and applied to both synthetic and real-world recommender ratings. For experimental purposes, the DWT methodology’s effect on predictive accuracy and calculation speed is evaluated to compare recommendation quality and performance.     

Characterisation of flucloxacillin and 5-hydroxymethyl flucloxacillin haptenated HSA in vitro and in vivo

Flucloxacillin is a synthetic penicillin used in the treatment of Staphylococcal infections. Adverse reactions to the drug are believed to arise through covalent modification of proteins, with tissue damage occurring secondary to an immune reaction. Serum proteins have been shown by adduct-specific antibodies to be modified by flucloxacillin, but the nature and sites of modification have not been characterised. Here, in vitro studies on HSA have shown by MS that the modification of protein lysine residues occurs in a dose-, time- and site-dependent manner. Affinity, cation exchange and reversed phase chromatography prior to MS revealed in vivo modification of HSA with flucloxacillin in tolerant patients, with up to nine modified lysine residues being detected in each patient, and with modification of Lys190 and Lys212 being detected in 8/8 patients. It was also revealed for the first time that plasma proteins could be modified with the 5-hydroxymethyl metabolite of flucloxacillin, and that essentially the same Lys residues were targeted by both the parent drug and its metabolite. This study provides a detailed characterisation of sites of chemical modification of an endogenous target and reveals candidate peptides for T-cell and antibody assays of flucloxacillin hypersensitivity.     

Insights into virus capsid assembly from non-covalent mass spectrometry

The assembly of viral proteins into a range of macromolecular complexes of strictly defined architecture is one of Nature's wonders. Unraveling the details of these complex structures and the associated self-assembly pathways that lead to their efficient and precise construction will play an important role in the development of anti-viral therapeutics. It will also be important in bio-nanotechnology where there is a plethora of applications for such well-defined macromolecular complexes, including cell-specific drug delivery and as substrates for the formation of novel materials with unique electrical and magnetic properties. Mass spectrometry has the ability not only to measure masses accurately but also to provide vital details regarding the composition and stoichiometry of intact, non-covalently bound macromolecular complexes under near-physiological conditions. It is thus ideal for exploring the assembly and function of viruses. Over the past decade or so, significant advances have been made in this field, and these advances are summarized in this review, which covers the literature up to the end of 2007.     

Energy coupled to matter for magnetic alignment of rare earth–doped alumina

Energy coupled to matter (ECM) concepts such as magnetic field–assisted processing were used to align rare earth–doped alumina ceramics in the presence of applied fields. The addition of gadolinium and ytterbium dopants to alumina increased the magnetic susceptibility anisotropies, and induced magnetic torques that led to significant alignment of ceramic particles under the application of magnetic fields as low as 1.8?T. In comparison, undoped alumina materials showed minimal alignment under applied field strengths as high as 9?T. Density function theory modeling indicated that the specific dopant type dictated changes in the magnetic properties of different rare earth–doped alumina systems by directly affecting the magnetic moment localization and magnetocrystalline anisotropy.     

A comparison between intermittent and constant wheelchair propulsion strategies

The purpose of this study was to investigate the effect of different synchronous push strategies on physiological parameters and temporal timing characteristics. Eight novice male able-bodied participants completed four counter-balanced conditions: two push strategies (constant pushing) and intermittent pushing (INT) at two push frequencies (40 and 70 pushes/min) at 27 W. The ANOVA main effects for frequency indicated that regardless of push strategy, oxygen cost and mechanical efficiency increased with an increase in push frequency (p < 0.01). The INT40 strategy resulted in the lowest heart rate (115 +/- 19 beats/min). With increased frequency the push angle was reduced (91 degrees vs. 78 degrees respectively) and the push was initiated at a more anterior position of the wheel (p < 0.05). The results suggest that regardless of push strategy, the over-riding factor that influences both the physiological and timing parameters measured was push frequency.     

Reuse of reverse osmosis membranes in advanced wastewater treatment

In areas where tap water has a high salt content, wastewater is not appropriate for reuse in agriculture, particularly for sensitive crops. One alternative is reduction, via desalination, of the brackish character to the secondary effluent. A filtration stage is also required before desalination. On the other hand, used reverse osmosis membranes can be recycled and used as filters in the advanced treatment stage in order to reduce suspended matter contained in the secondary effluent—one advantage being the environmental recovery of solid waste. Used membranes can be treated with strong chemical oxidants to peel off the active separation layer in order to transform them into microfiltration or ultrafiltration elements. Preliminary tests have been carried out with 8″ elements, aimed at comparing membrane performance before and after the peeling process. An index denoted as peeling effectiveness (high flux, high salt passage) is used for comparison. It was soon observed that potassium permanganate was more effective than others, together with sodium hydroxide. Doses around 1000 mg/L KMnO₄ provided the best results. It was also concluded that membrane cleaning, done with sodium bisulphite prior to peeling, was better when recirculating the cleaning solution around the membrane rather than soaking it. Next steps in the research will test the actual filtration capability of the peeled membranes in actual wastewater.     

Ontology-based user profile learning

Personal agents gather information about users in a user profile. In this work, we propose a novel ontology-based user profile learning. Particularly, we aim to learn context-enriched user profiles using data mining techniques and ontologies. We are interested in knowing to what extent data mining techniques can be used for user profile generation, and how to utilize ontologies for user profile improvement. The objective is to semantically enrich a user profile with contextual information by using association rules, Bayesian networks and ontologies in order to improve agent performance. At runtime, we learn which the relevant contexts to the user are based on the user’s behavior observation. Then, we represent the relevant contexts learnt as ontology segments. The encouraging experimental results show the usefulness of including semantics into a user profile as well as the advantages of integrating agents and data mining using ontologies.     

Project proposal for the investigation of particle-stabilised emulsions and foams by microgravity experiments

The utilisation of particle-surfactants nanostructures as stabilising agents represents today the technologic and scientific frontier in the stabilisation of liquid films in emulsion and foams. This topic will be addressed by the proposal STEFAN (STabilisation of Emulsions and FoAms by Nanoparticles), proposed by European groups in the framework of the ESA AO-2004 for Life and Physical Sciences and Applied Research projects Similarly to what can be observed for surfactant-stabilised emulsions and foams, microgravity provides ideal conditions for the investigation of the hierarchy of involved objects: interfacial layer, liquid film, dispersed systems foam or emulsion. Microgravity experiments are planned by refurbishing the Experimental Container FASES for the ISS Fluid Science Laboratory and the facility FASTER for the European Drawer Rack, already under development in existing research programmes. Here the scientific guidelines of the project are presented together with examples and preliminary results on the effect of nano-particle-surfactant structures adsorbed at liquid interfaces. First experimental results have been achieved for particle monolayers at the water/air interface and a thermodynamic model was derived to describe the obtained surface pressure-area isotherms.     

Towards an algebraic theory of information integration

Information integration systems provide uniform interfaces to varieties of heterogeneous information sources. For query answering in such systems, the current generation of query answering algorithms in local-as-view (source-centric) information integration systems all produce what has been thought of as “the best obtainable” answer, given the circumstances that the source-centric approach introduces incomplete information into the virtual global relations. However, this “best obtainable” answer does not include all information that can be extracted from the sources because it does not allow partial information. Neither does the “best obtainable” answer allow for composition of queries, meaning that querying a result of a previous query will not be equivalentto the composition of the two queries. In this paper, we provide a foundation for information integration, based on the algebraic theory of incomplete information. Our framework allows us to define the semantics of partial facts and introduce the notion of the exact answer—that is the answer that includes partial facts. We show that querying under the exact answer semantics is compositional. We also present two methods for actually computing the exact answer. The first method is tableau-based, and it is a generalization of the “inverse-rules” approach. The second, much more efficient method, is a generalization of the rewriting approach, and it is based on partial containment mappings introduced in the paper.