Fundamental limits on time delay estimation in dispersed spectrum cognitive radio systems

In this paper, fundamental limits on time delay estimation are studied for cognitive radio systems, which facilitate opportunistic use of spectral resources. First, a generic Cramer-Rao lower bound (CRLB) expression is obtained in the case of unknown channel coefficients and carrier-frequency offsets (CFOs) for cognitive radio systems with dispersed spectrum utilization. Then, various modulation schemes are considered, and the effects of unknown channel coefficients and CFOs on the accuracy of time delay estimation are quantified. Finally, numerical studies are performed in order to verify the theoretical analysis.     

A Safari Through the MPSoC Run-Time Management Jungle

The multiprocessor SoC (MPSoC) revolution is fueled by the need to execute multiple advanced multimedia applications on a single embedded computing platform. At design-time, the applications that will run in parallel and their respective user requirements are unknown. Hence, a run-time manager (RTM) is needed to match all application needs with the available platform resources and services. Creating such a run-time manager requires two decisions. First, one needs to decide what functionality to implement. Second, one has to decide how to implement this functionality in order to meet boundary conditions like e.g. real-time performance. This paper is the first to detail a generic view on MPSoC run-time management functionality and its design space trade-offs. We substantiate the run-time components and the implementation trade-offs with academic state-of-the-art solutions and a brief overview of some industrial multiprocessor run-time management examples. We show a clear trend towards more hardware acceleration, a limited distribution of management functionality over the platform and increasing support for adaptive multimedia applications. In addition, we briefly detail upcoming run-time management research issues.     

Who profits from the Canadian nanotechnology reward system? Implications for gender-responsible innovation

Scientometrics - Gender equality is one of the primary dimensions of responsible research and innovation. Based on bibliometric and survey data of nanotechnology researchers in Canada, this paper...     

Influence of morphologic texture on stress analysis by X-ray and neutron diffraction in single-phase metallic materials

In this work, a study on the influence of morphologic texture on the residual stress determination by diffraction in metallic materials with cubic and hexagonal symmetry is proposed. To this end, elastic self-consistent model has been developed to properly take into account the morphologic texture. Extreme crystallites morphologies (sphere, disc and fibre) were studied, and coupled with the crystallographic texture to reflect the combined effect of morphologic and crystallographic texture in elasticity. In the case of morphologic texture, a stronger influence than the crystallographic texture on the estimated residual stresses (several tens of MPa difference) was observed. We propose a methodology through a scale transition model to take into account the influence of these different morphologies in the stress analysis by diffraction methods. The main purpose of this work was to make the best choice for lattice planes (hkl) used for residual or internal stress analysis, in elasticity, depending on the morphologic (and crystallographic) texture of the polycrystal, especially when the usual X-ray Elasticity Constants (XECs) are used instead of the stress factors.     

Monoclonal Cell Line Generation and CRISPR/Cas9 Manipulation via Single‐Cell Electroporation

Stably transfected cell lines are widely used in drug discovery and biological research to produce recombinant proteins. Generation of these cell lines requires the isolation of multiple clones, using time‐consuming dilution methods, to evaluate the expression levels of the gene of interest. A new and efficient method is described for the generation of monoclonal cell lines, without the need for dilution cloning. In this new method, arrays of patterned cell colonies and single cell transfection are employed to deliver a plasmid coding for a reporter gene and conferring resistance to an antibiotic. Using a nanofountain probe electroporation system, probe positioning is achieved through a micromanipulator with sub‐micron resolution and resistance‐based feedback control. The array of patterned cell colonies allows for rapid selection of numerous stably transfected clonal cell lines located on the same culture well, conferring a significant advantage over slower and labor‐intensive traditional methods. In addition to plasmid integration, this methodology can be seamlessly combined with CRISPR/Cas9 gene editing, paving the way for advanced cell engineering.     

Validation of a new self-report measure of parental attributions.

Attributional theory and empirical evidence suggest that a tendency to make stable, global self-causal attributions for undesirable events is associated with negative outcomes. However, existing self-report measures of parental attributions do not account for the possibility that dysfunctional parent-causal attributions for child misbehavior might be important predictors of poor family functioning. To address these concerns, the authors developed and tested a new measure of both parent-causal and child-responsible attributions for child misbehavior in a sample of 453 community couples. Structural validity, convergent validity, discriminant validity, internal consistency, and temporal stability of the new measure were examined. As expected, confirmatory factor analysis resulted in 2 factors, Child-Responsible (9 items) and Parent-Causal (7 items); the final model was cross-validated in a holdout sample. The final scale demonstrated adequate internal consistency (αs = .81–.90), test–retest reliability (rs = .55–.76), and convergent and discriminant validity. Dysfunctional parent-causal and child-responsible attributions significantly predicted parental emotional problems, ineffective discipline, parent–child physical aggression, and low parenting satisfaction. Associations with parent–child aggression and parenting satisfaction were generally larger than with partner aggression and relationship satisfaction. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Increased conversion efficiency in cadmium telluride photovoltaics by luminescent downshifting with quantum dot/poly(methyl methacrylate) films

Commercially available quantum dots have been encapsulated in a poly(methyl methacrylate) film and used as a luminescent downshifting layer on cadmium sulfide/cadmium telluride photovoltaic devices. Application of these films has resulted in a relative improvement to the short‐circuit current of over 4% by I–V measurement, with a significant increase in the contribution of short‐wavelength light resulting in 25% of the current available in this part of the spectrum being captured. The films have been shown to be highly scattering and the associated difficulties this provides to external quantum efficiency measurements have been discussed. A range of optical characterisation techniques, particularly laser beam induced current, have been used to probe the effect the films have on a cadmium sulfide/cadmium telluride device. An alternate methodology for performing external quantum efficiency measurements with the quantum dot films has been proposed. Copyright © 2013 John Wiley & Sons, Ltd.     

Influence of a metallic filler on polyurethane formation

The addition of metallic fillers is recognized to impart improvement of acoustic properties to polyurethane-based materials used for marine applications. The system under consideration was obtained by the reaction of a triisocyanateterminated prepolymer with 1,4-butanediol, in the presence of various concentrations of lead powder. With increasing lead content, gelation time is reduced and an Einstein-type law does not apply. The kinetics of the reaction were determined by Fourier transform infrared spectroscopy. Deviation from the classic second order is observed for the filled systems, and the higher the lead content, the more important the deviation is, showing undoubtedly the catalytic effect of the metallic powder.     

Human Chorionic Gonadotropin and Early Embryogenesis: Review

Human chorionic gonadotropin (hCG) has four major isoforms: classical hCG, hyperglycosylated hCG, free β subunit, and sulphated hCG. Classical hCG is the first molecule synthesized by the embryo. Its RNA is transcribed as early as the eight-cell stage and the blastocyst produces the protein before its implantation. This review synthetizes everything currently known on this multi-effect hormone: hCG levels, angiogenetic activity, immunological actions, and effects on miscarriages and thyroid function.     

Immune Checkpoint Blockade in Advanced Cutaneous Squamous Cell Carcinoma: What Do We Currently Know in 2020?

Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer that predominantly arises in chronically sun-damaged skin. Immunosuppression, genetic disorders such as xeroderma pigmentosum (XP), exposure to certain drugs and environmental noxae have been identified as major risk factors. Surgical removal of cSCC is the therapy of choice and mostly curative in early stages. However, a minority of patients develop locally advanced tumors or distant metastases that are still challenging to treat. Immune checkpoint blockade (ICB) targeting CTLA-4, PD-L1 and PD-1 has tremendously changed the field of oncological therapy and especially the treatment of skin cancers as tumors with a high mutational burden. In this review, we focus on the differences between cSCC and cutaneous melanoma (CM) and their implications on therapy, summarize the current evidence on ICB for the treatment of advanced cSCC and discuss the chances and pitfalls of this therapy option for this cancer entity. Furthermore, we focus on special subgroups of interest such as organ transplant recipients, patients with hematologic malignancies, XP and field cancerization.