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81.
Vincent Lemiale Yuri Estrin Hyoung Seop Kim Robert O’Donnell 《Metallurgical and Materials Transactions A》2011,42(10):3006-3012
Grain refinement by plastic deformation is becoming increasingly popular as a way of producing metals with improved properties,
such as higher mechanical strength. Surface treatment techniques in which a metallic substrate is bombarded with metallic
particles can generate nanocrystalline layers in the impact zone. Understanding the physical mechanisms underlying this grain
refinement is crucial for achieving an improvement of existing experimental processes. In this article, we propose a numerical
framework combining finite element (FE) simulations with a dislocation-based material model to predict the evolution of the
microstructure under particle impact. A single particle normally impacting on a metallic substrate was simulated at different
initial velocities. The simulations were compared with previously reported numerical and experimental data. The results indicate
that our model accurately captures the grain refinement in the impact zone for a broad range of velocities. This approach
provides valuable information on the formation of nanocrystalline layers in both the substrate and the impacting particle.
Its potential applications include processes involving surface treatment by high velocity particles, such as shot peening,
surface mechanical attrition treatment, kinetic metallization, cold spray, etc. 相似文献
82.
Modeling heterogeneous bacterial populations exposed to antibiotics: The logistic‐dynamics case 下载免费PDF全文
Pratik R. Bhagunde Michael Nikolaou Vincent H. Tam 《American Institute of Chemical Engineers》2015,61(8):2385-2393
In typical in vitro tests for clinical use or development of antibiotics, samples from a bacterial population are exposed to an antibiotic at various concentrations. The resulting data can then be used to build a mathematical model suitable for dosing regimen design or for further development. For bacterial populations that include resistant subpopulations—an issue that has reached alarming proportions—building such a model is challenging. In prior work, we developed a related modeling framework for such heterogeneous bacterial populations following linear dynamics when exposed to an antibiotic. We extend this framework to the case of logistic dynamics, common among strongly resistant bacterial strains. Explicit formulas are developed that can be easily used in parameter estimation and subsequent dosing regimen design under realistic pharmacokinetic conditions. A case study using experimental data from the effect of an antibiotic on a gram‐negative bacterial population exemplifies the usefulness of the proposed approach. © 2015 American Institute of Chemical Engineers AIChE J, 61: 2385–2393, 2015 相似文献
83.
Vincent Iacobellis Kamran Behdinan 《International journal for numerical methods in engineering》2015,104(13):1200-1216
The previously developed bridging cell method for modeling coupled continuum/atomistic systems at finite temperature is used to model fatigue crack growth in single crystal nickel under two crystal orientations at different temperatures. The method is expanded to implement a temperature‐dependent embedded atom method potential for finite temperature simulations avoiding time‐scale restrictions associated with small timesteps. Results for the fatigue simulation were compared with respect to deformation behavior, stress distribution, and crack length. Results showed very different crack growth mechanisms between the two crystal orientations as well as reduced resistance to crack growth with increased temperature. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
84.
Bulky End‐Capped [1]Benzothieno[3,2‐b]benzothiophenes: Reaching High‐Mobility Organic Semiconductors by Fine Tuning of the Crystalline Solid‐State Order 下载免费PDF全文
Guillaume Schweicher Vincent Lemaur Claude Niebel Christian Ruzié Ying Diao Osamu Goto Wen‐Ya Lee Yeongin Kim Jean‐Baptiste Arlin Jolanta Karpinska Alan R. Kennedy Sean R. Parkin Yoann Olivier Stefan C. B. Mannsfeld Jérôme Cornil Yves H. Geerts Zhenan Bao 《Advanced materials (Deerfield Beach, Fla.)》2015,27(19):3066-3072
85.
Issues with Combining Road Elevation Spectral Models and Vehicle Vibration Response to Estimate Vehicle Dynamic Characteristics 下载免费PDF全文
The research presented in this paper focuses on issues associated with the development of an experimental technique to estimate the dynamic characteristics of wheeled vehicles (namely, the frequency response function) using only in‐service response data. To validate the approach and eliminate complexities associated with multi‐wheel vehicles, a single‐wheeled prototype vehicle was designed and commissioned. The vertical vibration acceleration of the prototype vehicle's sprung mass was measured during normal operation. The power spectral density function was computed and used to estimate the frequency response function of the vehicle. A number of experiments using various configurations of the single‐wheeled prototype vehicle were undertaken, along with a series of vibration table experiments to provide a comparison with the estimated frequency response functions. The results show that the best estimate of the frequency response function using the vehicle response data provides reasonable agreement with the measured laboratory experiments when the value of the slope of the spectral function is not set to the value suggested by the International Organisation for Standardisation. Another technique was further developed to estimate the value of the pavement spectral slope using only in‐service response data; however, this technique does not yield consistent and accurate estimates. Interestingly, the main resonance of the vehicle is in agreement between the vibration table and response data around the sprung mass of all three vehicle configurations when inspected using linear scales (regardless of the variation in the spectral shape of the excitation), although the additional modes (including the unsprung mass) differs for all vehicles. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
86.
Free-living amoebae (FLA) are protozoa that can be found in water networks where they prey on bacteria within biofilms. Most bacteria are digested rapidly by phagocytosis, however some are able to survive within amoebae and some are even able to multiply, as it is the case for Legionella pneumophila. These resisting bacteria are a potential health problem as they could also resist to macrophage phagocytosis. Several publications already reported intra-amoebal bacteria but the methods of identification did not allow metagenomic analysis and are partly based on co-culture with one selected amoebal strain. The aim of our study was to conduct a rRNA-targeted metagenomic analysis on amoebae and intra-amoebal bacteria found in drinking water network, to provide the first FLA microbiome in environmental strains. Three sites of a water network were sampled during four months. Culturable FLA were isolated and total DNA was prepared, allowing purification of both amoebal and bacterial DNA. Metagenomic studies were then conducted through 18S or 16S amplicons sequencing. Hartmannella was by far the most represented genus of FLA. Regarding intra-amoebal bacteria, 54 genera were identified, among which 21 were newly described intra-amoebal bacteria, underlying the power of our approach. There were high differences in bacterial diversity between the three sites. Several genera were highly represented and/or found at least in two sites, underlying that these bacteria could be able to multiply within FLA. Our method is therefore useful to identify FLA microbiome and could be applied to other networks to have a more comprehensive view of intra-amoebal diversity. 相似文献
87.
Structure–Activity Relationships of JMV4463, a Vectorized Cathepsin D Inhibitor with Antiproliferative Properties: The Unique Role of the AMPA‐Based Vector 下载免费PDF全文
Dr. Lubomir L. Vezenkov Clément A. Sanchez Dr. Virginie Bellet Dr. Vincent Martin Dr. Marie Maynadier Dr. Nadir Bettache Prof. Vincent Lisowski Prof. Jean Martinez Dr. Marcel Garcia Dr. Muriel Amblard Dr. Jean‐François Hernandez 《ChemMedChem》2016,11(3):302-308
Cathepsin D (CathD) is overexpressed and secreted by several solid tumors and stimulates their growth, the mechanism of which is still not understood. In this context, the pepstatin bioconjugate JMV4463 [Ac‐arg‐O2Oc‐(Val)3‐Sta‐Ala‐Sta‐(AMPA)4‐NH2; O2Oc=8‐amino‐3,6‐dioxaoctanoyl, Sta=statine, AMPA=ortho‐aminomethylphenylacetyl], containing a new kind of cell‐penetrating vector, was previously shown to exhibit potent antiproliferative effects in vitro and to delay the onset of tumors in vivo. In this study, we performed a structure–activity relationship analysis to evaluate the significance of the inhibitor and vector moieties of JMV4463. By modifying both statine residues of pepstatin we found that the antiproliferative activity is correlated with CathD inhibition, supporting a major role of the catalytic activity of intracellular CathD in cancer cell proliferation. Replacing the vector composed of four AMPA units with other vectors was found to abolish cytotoxicity, although all of the conjugates enabled pepstatin transport into cells. In addition, the AMPA4 vector must be localized at the C terminus of the bioconjugate. The unexpected importance of the vector structure and position for cytotoxic action suggests that AMPA4 enables pepstatin to inhibit the proteolysis of critical CathD substrates involved in cell proliferation via a unique mechanism of action. 相似文献
88.
Yalou Guo Vincent Jusko Gongkui Xiao Jurgen Hanekom Guoping Hu Paul A. Webley Eric F. May Gang Kevin Li 《American Institute of Chemical Engineers》2022,68(5):e17569
Conventional pressure swing adsorption (PSA) processes can only produce one high purity product in a single stage, whereas the state-of-art dual-reflux PSA (DR-PSA) can produce two high purity products simultaneously. However, multicomponent gas separation is often required in the industry, targeting at recovering several valued products at the same time. In this study, we propose a novel adsorption process, namely triple-reflux PSA (TR-PSA), to separate three components simultaneously. A middle product outlet and a middle reflux stream were introduced to the adsorption columns of a conventional DR-PSA process to separate ternary mixtures of nitrogen, methane, and helium. Nonisothermal dynamic models were built to investigate the impacts of operating parameters particularly the location of the middle reflux/product stream and the middle reflux flow rates. Results showed that the TR-PSA process successfully separated ternary mixtures obtaining three enriched products simultaneously in a single stage, yielding a separation performance comparable to that of the double-stage DR-PSA with significantly lower capital and energy cost. 相似文献
89.
Simon D. Hodgson William S. M. Brooks Andrew J. Clayton Giray Kartopu Daniel A. Lamb Vincent Barrioz Stuart J. C. Irvine 《Progress in Photovoltaics: Research and Applications》2015,23(2):150-159
Commercially available quantum dots have been encapsulated in a poly(methyl methacrylate) film and used as a luminescent downshifting layer on cadmium sulfide/cadmium telluride photovoltaic devices. Application of these films has resulted in a relative improvement to the short‐circuit current of over 4% by I–V measurement, with a significant increase in the contribution of short‐wavelength light resulting in 25% of the current available in this part of the spectrum being captured. The films have been shown to be highly scattering and the associated difficulties this provides to external quantum efficiency measurements have been discussed. A range of optical characterisation techniques, particularly laser beam induced current, have been used to probe the effect the films have on a cadmium sulfide/cadmium telluride device. An alternate methodology for performing external quantum efficiency measurements with the quantum dot films has been proposed. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
90.