A behavioral-based multi-agent optimization algorithm for system level radio design

This paper introduces a multi-agent behavioral-based optimization algorithm for system level radio design. Making multi-standard wireless communication receivers that meet their specs while keeping the requirements of the individual blocks as relaxed as possible is the goal of this algorithm. In order to achieve this goal a “divide and conquer” approach is proposed. Different agents focus on different objectives that are pursued in parallel. Agents adopt different behaviors depending on the status of the environment and their interaction with other agents. Agents are cooperative by default as they try to meet their spec without making changes that affect other agents. However, more aggressive behaviors that lead to global changes can be adopted when needed. The interaction between these simple entities yields an emergent behavior able to deal smoothly with the complexity of the problem at hand.     

Polysiloxane‐lignin composites

A series of composites based on polydimethylsiloxane‐α,ω‐diol (PDMS) as polymeric matrix, silica aerogel as reinforcing filler, and the lignin powder—a biomass derivative, as bulking filler, have been prepared. Different weight ratios between components were used. The composites were investigated by scanning electron microscopy, dynamic mechanical analysis, tensile strength tests, X‐ray diffraction analysis, thermogravimetric analysis, and differential scanning calorimetry. The results were compared with those obtained on a reference sample prepared by using a classical material—diatomite and a pure crosslinked PDMS. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009     

Multi-element including rare earth content of lichens, bark, soils, and waste following industrial closure

The fate of rare earth and other rare elements entering the environment is largely unknown. The lichen Hypogymnia physodes was transplanted over a 40 km long transect centered on a major metallurgical waste dump close to the Zlatna town center two weeks after smelter closure. Lichens, bark, soil, and waste dump materials were analyzed for 56 elements (including REE). Lichen and bark multi-element compositions were alike, reflecting fixation of elements of environmental concern and the ability for tree canopies to concentrate substances leading to enhanced deposition to both lichens and bark. Higher REE enrichment in lichens than in soil confirm efficient fixation in lichens. The negative europium anomaly in lichens and soil, similar to that in upper crust, confirm a strong crustal influence on lichen signatures across the transect area. Multi-element analysis supports the view that epiphytic lichens, unlike trees, are not influenced by lower groundwater, and they are excellent indicators for REE and other rare elements entering the surface environment, difficult to detect by conventional means.     

Cell-Permeable Succinate Rescues Mitochondrial Respiration in Cellular Models of Statin Toxicity

Statins are the cornerstone of lipid-lowering therapy. Although generally well tolerated, statin-associated muscle symptoms (SAMS) represent the main reason for treatment discontinuation. Mitochondrial dysfunction of complex I has been implicated in the pathophysiology of SAMS. The present study proposed to assess the concentration-dependent ex vivo effects of three statins on mitochondrial respiration in viable human platelets and to investigate whether a cell-permeable prodrug of succinate (complex II substrate) can compensate for statin-induced mitochondrial dysfunction. Mitochondrial respiration was assessed by high-resolution respirometry in human platelets, acutely exposed to statins in the presence/absence of the prodrug NV118. Statins concentration-dependently inhibited mitochondrial respiration in both intact and permeabilized cells. Further, statins caused an increase in non-ATP generating oxygen consumption (uncoupling), severely limiting the OXPHOS coupling efficiency, a measure of the ATP generating capacity. Cerivastatin (commercially withdrawn due to muscle toxicity) displayed a similar inhibitory capacity compared with the widely prescribed and tolerable atorvastatin, but did not elicit direct complex I inhibition. NV118 increased succinate-supported mitochondrial oxygen consumption in atorvastatin/cerivastatin-exposed platelets leading to normalization of coupled (ATP generating) respiration. The results acquired in isolated human platelets were validated in a limited set of experiments using atorvastatin in HepG2 cells, reinforcing the generalizability of the findings.     

3D multi-material and multi-joint topology optimization with tooling accessibility constraints

Structural and Multidisciplinary Optimization - This paper proposes a method for performing both multi-material topology optimization and multi-joint topology optimization. The algorithm can...     

Coumarins from Seseli devenyense Simonk.: Isolation by Liquid–Liquid Chromatography and Potential Anxiolytic Activity Using an In Vivo Zebrafish Larvae Model

Different types of anxiety disorders have become the number one mental health issue in developed countries. The search for new, safer and effective drug-like molecules among naturally derived substances faces two difficulties: an efficient method of isolation compounds with a high-purity and high-throughput animal model for activity assay. Thus, the aim of the present study was to isolate by liquid–liquid chromatography high-purity rare coumarins from the fruits of Seseli devenyense Simonk. and evaluate their anxiolytic effect (defined as reversed thimotaxis) using a 5-days post-fertilization (dpf) Danio rerio larvae model. Liquid–liquid chromatography enabled the isolation of one simple hydroxycoumarin (devenyol) and four pyranocoumarins (cis-khellactone, d-laserpitin, isolaserpitin and octanoyllomatin). The anxiolytic effect was defined as a decrease in the time spent in the boundaries of the living space (also described as reversed thigmotaxis). Our results show that all isolated courmarins exerted a significant influence on the anxiety behavior (anxiolytic activity) in the zebrafish larvae model. According to our knowledge, this is the first report of anxiolytic activity of pyranocoumarins and devenyol.     

Processing and properties of a new biodegradable Mg−Zn−Ca−Zr alloy

Magnesium alloys are used for degradable orthopaedic and cardiovascular implants due to their favourable mechanical and biological properties, degradation ability in physiological environment and stimulatory effect on the new bone formation. The research challenges are related to the increase of biological and mechanical compatibility. For the present study, a magnesium based alloy design was conducted to the following chemical composition: Mg?2.7Zn?1Ca?0.6Zr (wt.%). A complex thermomechanical processing route was applied: a plastic deformation by extrusion at various temperatures and deformation degrees (400 °C–480 °C, ? = 20 %–40 %), followed by various final heat treatments at 200 °C–400 °C for 10 min–60 min. Further, the influence of processing parameters upon the structure, mechanical properties and biological response was studied. Processed specimens were characterized by scanning electron microscopy (secondary electron imaging and energy dispersive spectroscopy) and mechanically by tensile tests. The most representative results were obtained for the samples extruded at 450 °C/? = 20 %, followed by a final heat treatment at 350 °C/15 min, air cooling. Further, for samples which revealed promising results, in‐vitro testing was developed. Biocompatibility testing of the Mg?2.7Zn?1Ca?0.6Zr (wt.%) alloy was realized by indirect contact studies using the Vero (ATCC® CCL‐81?, American Type Culture Collection) cell line. Cells morphologies, cell viability and proliferation were evaluated.     

Two-dimensional simulation and modeling in scanning electron microscope imaging and metrology research

Traditional Monte Carlo modeling of the electron beam-specimen interactions in a scanning electron microscope (SEM) produces information about electron beam penetration and output signal generation at either a single beam-landing location, or multiple landing positions. If the multiple landings lie on a line, the results can be graphed in a line scan-like format. Monte Carlo results formatted as line scans have proven useful in providing one-dimensional information about the sample (e.g., linewidth). When used this way, this process is called forward line scan modeling. In the present work, the concept of image simulation (or the first step in the inverse modeling of images) is introduced where the forward-modeled line scan data are carried one step further to construct theoretical two-dimensional (2-D) micrographs (i.e., theoretical SEM images) for comparison with similar experimentally obtained micrographs. This provides an ability to mimic and closely match theory and experiment using SEM images. Calculated and/or measured libraries of simulated images can be developed with this technique. The library concept will prove to be very useful in the determination of dimensional and other properties of simple structures, such as integrated circuit parts, where the shape of the features is preferably measured from a single top-down image or a line scan. This paper presents one approach to the generation of 2-D simulated images and presents some suggestions as to their application to critical dimension metrology.     

VMTL: a language for end-user model transformation

Model transformation is a key enabling technology of Model-Driven Engineering (MDE). Existing model transformation languages are shaped by and for MDE practitioners—a user group with needs and capabilities which are not necessarily characteristic of modelers in general. Consequently, these languages are largely ill-equipped for adoption by end-user modelers in areas such as requirements engineering, business process management, or enterprise architecture. We aim to introduce a model transformation language addressing the skills and requirements of end-user modelers. With this contribution, we hope to broaden the application scope of model transformation and MDE technology in general. We discuss the profile of end-user modelers and propose a set of design guidelines for model transformation languages addressing them. We then introduce Visual Model Transformation Language (VMTL) following these guidelines. VMTL draws on our previous work on the usability-oriented Visual Model Query Language. We implement VMTL using the Henshin model transformation engine, and empirically investigate its learnability via two user experiments and a think-aloud protocol analysis. Our experiments, although conducted on computer science students exhibiting only some of the characteristics of end-user modelers, show that VMTL compares favorably in terms of learnability with two state-of the-art model transformation languages: Epsilon and Henshin. Our think-aloud protocol analysis confirms many of the design decisions adopted for VMTL, while also indicating possible improvements.