VerifyThis 2015

VerifyThis 2015 was a one-day program verification competition which took place on April 12th, 2015 in London, UK, as part of the European Joint Conferences on Theory and Practice of Software (ETAPS 2015). It was the fourth instalment in the VerifyThis competition series. This article provides an overview of the VerifyThis 2015 event, the challenges that were posed during the competition, and a high-level overview of the solutions to these challenges. It concludes with the results of the competition and some ideas and thoughts for future instalments of VerifyThis.     

Knowledge transfer in SVM and neural networks

The paper considers general machine learning models, where knowledge transfer is positioned as the main method to improve their convergence properties. Previous research was focused on mechanisms of knowledge transfer in the context of SVM framework; the paper shows that this mechanism is applicable to neural network framework as well. The paper describes several general approaches for knowledge transfer in both SVM and ANN frameworks and illustrates algorithmic implementations and performance of one of these approaches for several synthetic examples.     

Predictive control of systems with Markovian jumps under constraints and its application to the investment portfolio optimization

In the paper, we study a problem of control with a predictive model for discrete systems with Markovian jumps and multiplicative noises. A strategy to control with regard for explicit constraints on control variables is defined. The results are applied to control an investment portfolio under constraints on investment amounts.     

Hierarchical mapping of Northern Eurasian land cover using MODIS data

The Northern Eurasian land mass encompasses a diverse array of land cover types including tundra, boreal forest, wetlands, semi-arid steppe, and agricultural land use. Despite the well-established importance of Northern Eurasia in the global carbon and climate system, the distribution and properties of land cover in this region are not well characterized. To address this knowledge and data gap, a hierarchical mapping approach was developed that encompasses the study area for the Northern Eurasia Earth System Partnership Initiative (NEESPI). The Northern Eurasia Land Cover (NELC) database developed in this study follows the FAO-Land Cover Classification System and provides nested groupings of land cover characteristics, with separate layers for land use, wetlands, and tundra. The database implementation is substantially different from other large-scale land cover datasets that provide maps based on a single set of discrete classes. By providing a database consisting of nested maps and complementary layers, the NELC database provides a flexible framework that allows users to tailor maps to suit their needs. The methods used to create the database combine empirically derived climate–vegetation relationships with results from supervised classifications based on Moderate Resolution Imaging Spectroradiometer (MODIS) data. The hierarchical approach provides an effective framework for integrating climate–vegetation relationships with remote sensing-based classifications, and also allows sources of error to be characterized and attributed to specific levels in the hierarchy. The cross-validated accuracy was 73% for the land cover map and 73% and 91% for the agriculture and wetland classifications, respectively. These results support the use of hierarchical classification and climate–vegetation relationships for mapping land cover at continental scales.     

Robust Control Using Interval Analysis

The synthesis procedure of a control law that guarantees properties of robust stability with respect to structured parameter perturbations is proposed. The solution of the considered problem is based on the Razumikhin's method for functional differential equations generalized for parameter perturbation systems with time delay. The extension is obtained by using interval Lyapunov functions. The robust control law is represented through a solution of an interval matrix Riccati type equation.     

Suboptimal filter for continuous‐time linear systems with unknown parameters

The filtering problem for continuous‐time linear systems with unknown parameters is considered. A new suboptimal filter is herein proposed. It is based on the optimal mean‐square linear combination of the local Kalman filters. In contrast to the optimal weights, the suboptimal weights do not depend on current observations; thus, the proposed filter can easily be implemented in real‐time. Examples demonstrate high accuracy and efficiency of the suboptimal filter. Copyright © 2008 John Wiley and Sons Asia Pte Ltd and Chinese Automatic Control Society     

Multi-digit maximum voluntary torque production on a circular object

Individual digit-tip forces and moments during torque production on a mechanically fixed circular object were studied. During the experiments, subjects positioned each digit on a 6-dimensional force/moment sensor attached to a circular handle and produced a maximum voluntary torque on the handle. The torque direction and the orientation of the torque axis were varied. From this study, it is concluded that: (1) the maximum torque in the closing (clockwise) direction was larger than in the opening (counter clockwise) direction; (2) the thumb and little finger had the largest and the smallest share of both total normal force and total moment, respectively; (3) the sharing of total moment between individual digits was not affected by the orientation of the torque axis or by the torque direction, while the sharing of total normal force between the individual digit varied with torque direction; (4) the normal force safety margins were largest and smallest in the thumb and little finger, respectively.     

Computer aided comparative analysis of the binding modes of the adenosine receptor agonists for all known subtypes of adenosine receptors

Molecular models of all known subtypes (A1, A2A, A2B, and A3) of the human adenosine receptors were built in homology with bovine rhodopsin. These models include the transmembrane domain as well as all extracellular and intracellular hydrophilic loops and terminal domains. The molecular docking of adenosine and 46 selected derivatives was performed for each receptor subtype. A binding mode common for all studied agonists was proposed, and possible explanations for differences in the ligand activities were suggested.     

Proteomic expression profiling of thyroid neoplasms

Thyroid cancer is the most common endocrine neoplasm with multiple histologic subtypes, each associated with different treatments and outcomes. Differentiating benign neoplasms such as follicular adenomas from malignant entities such as follicular carcinomas and papillary carcinoma can be challenging. To define the proteomic profile of different thyroid tumors, we screened an antibody array of 330 features against five thyroid neoplasms: follicular adenoma, follicular carcinoma, papillary carcinoma, anaplastic carcinoma, and medullary carcinoma as well as normal thyroid epithelium. Eight candidate biomarkers; c-erbB-2, Stat5a, Annexin IV, IL-11, RARα, FGF7, Caspase 9, and phospho-c-myc were identified as differentially expressed on the antibody array, and validated with immunohistochemistry on tissue microarrays, with a total of 144 samples of the same variety of thyroid neoplasms. Analysis revealed c-erbB-2, Annexin IV, and Stat5a have potential clinical utility to differentiate follicular adenoma, follicular carcinoma, and papillary carcinoma from each other. By using an antibody array as a discovery platform and a tissue microarray as a first step in validation on a large number of specimens, we have identified new markers that have potential utility in the diagnosis of thyroid neoplasms.