全文获取类型
收费全文 | 1743篇 |
免费 | 88篇 |
国内免费 | 1篇 |
专业分类
电工技术 | 21篇 |
综合类 | 15篇 |
化学工业 | 513篇 |
金属工艺 | 26篇 |
机械仪表 | 26篇 |
建筑科学 | 134篇 |
矿业工程 | 5篇 |
能源动力 | 42篇 |
轻工业 | 110篇 |
水利工程 | 5篇 |
石油天然气 | 1篇 |
无线电 | 106篇 |
一般工业技术 | 360篇 |
冶金工业 | 125篇 |
原子能技术 | 9篇 |
自动化技术 | 334篇 |
出版年
2023年 | 19篇 |
2022年 | 21篇 |
2021年 | 38篇 |
2020年 | 40篇 |
2019年 | 37篇 |
2018年 | 47篇 |
2017年 | 20篇 |
2016年 | 44篇 |
2015年 | 37篇 |
2014年 | 81篇 |
2013年 | 102篇 |
2012年 | 101篇 |
2011年 | 153篇 |
2010年 | 94篇 |
2009年 | 78篇 |
2008年 | 85篇 |
2007年 | 87篇 |
2006年 | 73篇 |
2005年 | 50篇 |
2004年 | 59篇 |
2003年 | 42篇 |
2002年 | 53篇 |
2001年 | 32篇 |
2000年 | 27篇 |
1999年 | 34篇 |
1998年 | 54篇 |
1997年 | 53篇 |
1996年 | 23篇 |
1995年 | 23篇 |
1994年 | 19篇 |
1993年 | 14篇 |
1992年 | 19篇 |
1991年 | 9篇 |
1990年 | 15篇 |
1989年 | 14篇 |
1988年 | 11篇 |
1987年 | 7篇 |
1985年 | 5篇 |
1984年 | 8篇 |
1983年 | 7篇 |
1982年 | 7篇 |
1981年 | 8篇 |
1980年 | 9篇 |
1979年 | 6篇 |
1978年 | 5篇 |
1977年 | 9篇 |
1976年 | 9篇 |
1975年 | 10篇 |
1973年 | 4篇 |
1970年 | 4篇 |
排序方式: 共有1832条查询结果,搜索用时 15 毫秒
191.
Volker Siegel 《Informatik-Spektrum》2005,28(5):403-406
Zusammenfassung Quellcodehinterlegung ist in Deutschland in den letzten Jahren zum üblichen Bestandteil eines wirksamen Risikomanagements
geworden. Softwareh?user k?nnen davon genauso profitieren wie deren Kunden. Dieser Artikel erg?nzt auch den Artikel “Escrow
Management bei elektronischer Archivierung” von Frau Rechtsanw?ltin Prof. Ursula Sury1 um die rechtlichen und technischen Aspekte der Quellcodehinterlegung. 相似文献
192.
Marie Stiborová Eva Frei Heinz H. Schmeiser Volker M. Arlt Václav Martínek 《International journal of molecular sciences》2014,15(6):10271-10295
This review summarizes the results found in studies investigating the enzymatic activation of two genotoxic nitro-aromatics, an environmental pollutant and carcinogen 3-nitrobenzanthrone (3-NBA) and a natural plant nephrotoxin and carcinogen aristolochic acid I (AAI), to reactive species forming covalent DNA adducts. Experimental and theoretical approaches determined the reasons why human NAD(P)H:quinone oxidoreductase (NQO1) and cytochromes P450 (CYP) 1A1 and 1A2 have the potential to reductively activate both nitro-aromatics. The results also contributed to the elucidation of the molecular mechanisms of these reactions. The contribution of conjugation enzymes such as N,O-acetyltransferases (NATs) and sulfotransferases (SULTs) to the activation of 3-NBA and AAI was also examined. The results indicated differences in the abilities of 3-NBA and AAI metabolites to be further activated by these conjugation enzymes. The formation of DNA adducts generated by both carcinogens during their reductive activation by the NOQ1 and CYP1A1/2 enzymes was investigated with pure enzymes, enzymes present in subcellular cytosolic and microsomal fractions, selective inhibitors, and animal models (including knock-out and humanized animals). For the theoretical approaches, flexible in silico docking methods as well as ab initio calculations were employed. The results summarized in this review demonstrate that a combination of experimental and theoretical approaches is a useful tool to study the enzyme-mediated reaction mechanisms of 3-NBA and AAI reduction. 相似文献
193.
194.
Dr. Carolyn Vargas Prof. Dr. Gerald Radziwill Dr. Gerd Krause Dr. Anne Diehl Prof. Dr. Sandro Keller Dr. Nestor Kamdem Prof. Dr. Constantin Czekelius Annika Kreuchwig Dr. Peter Schmieder Dr. Declan Doyle Prof. Dr. Karin Moelling Dr. Volker Hagen Dr. Markus Schade Prof. Dr. Hartmut Oschkinat 《ChemMedChem》2014,9(7):1458-1462
PDZ (PSD‐95, Dlg, ZO‐1) domains are ubiquitous interaction modules that are involved in many cellular signal transduction pathways. Interference with PDZ‐mediated protein–protein interactions has important implications in disease‐related signaling processes. For this reason, PDZ domains have gained attention as potential targets for inhibitor design and, in the long run, drug development. Herein we report the development of small molecules to probe the function of the PDZ domain from human AF6 (ALL1‐fused gene from chromosome 6), which is an essential component of cell–cell junctions. These compounds bind to AF6 PDZ with substantially higher affinity than the peptide (Ile‐Gln‐Ser‐Val‐Glu‐Val) derived from its natural ligand, EphB2. In intact cells, the compounds inhibit the AF6–Bcr interaction and interfere with epidermal growth factor (EGF)‐dependent signaling. 相似文献
195.
196.
197.
Volker Wittwer 《Renewable Energy》1994,5(1-4)
The new class of transparent insulation materials is classified and characterisation methods are summarised. An overview on available materials and a comparison of these new materials with conventional glazing systems is given. The high potential of these materials in collector systems is briefly discussed. In the final section an overview on new optical switching materials is given, which may help to achieve economically interesting system costs. 相似文献
198.
199.
200.