Evaluation of 2-benzylidenecyclohexanones and 2,6-bis(benzylidene)cyclohexanones for antitumor and cytotoxic activity and as inhibitors of mitochondrial function in yeast: metabolism studies of (E)-2-benzylidenecyclohexanone

Some 2-benzylidenecyclohexanones, 2,6-bis(benzylidene)cyclohexanones, and related compounds were evaluated for antitumor and cytotoxic activities; (E)-2-benzylidenecyclohexanone (Ia) was shown to have significant cytotoxic properties and a potent inhibitory effect on yeast mitochondria. After intraperitoneal injection of Ia, unchanged drug and a metabolite, tentatively identified as 2-(p-hydroxybenzyl)cyclohexanol, were found in the urine. No metabolites were found in the feces. Oral administration of Ia afforded three unidentified metabolites in the urine and three unidentified metabolites in the feces.     

10 kV混合配电线路载波信道特性测试与分析

配电线载波通信以其安装简便、投资小、运行免费等优点,逐步成为城市配电自动化通信的重要通信方式.近年来,10 kV配电线屏蔽层载波通信一直是研究的热点.然而受制于城市10 kV配电线路改造的进度,配电线路出现大量屏蔽层不完整、地埋电缆与架空线路相结合的混合线路.此类线路是否可以实现载波通信,也成为配电自动化通信建设的研究重点.文章选择2条典型的10 kV混合配电线路,对其电缆阻抗、噪声、传输衰耗特性进行测试与分析.测试结果表明,采用卡接式电感耦合方式的混合配电线路可以作为载波通信的媒介,为城市配电自动化通信建设提供有效的解决方案.     

基于载流子注入的SOI 4×4MMI-MZ光开关阵列

采用0.8μm CMOS工艺线制作了一种基于载流子注入的SOI 4×4马赫-曾德(MZ)光开关阵列,其由4个2×2基于多模干涉(MMI)耦合器的MZ(MMI-MZ)光开关单元组成。通过对调制臂施加电压,利用Si的载流子色散效应引起调制区的折射率变化实现开关功能。测试结果表明,当输入光为1 510～1 580nm的宽带光源时,光开关阵列的不同路径间的串扰低于-8.02dB,支持的公共带宽为35nm(1 530～1 565nm),开关阵列的上升和下降时间分别为17.4ns和21ns。     

Potential for oxytetracycline administration by three routes to cause milk residues in lactating cows, as detected by radioimmunoassay (Charm II) and high-performance liquid chromatography test methods

Milk antimicrobial residues are a serious concern for the dairy industry. Residues of the tetracycline family of antimicrobials have been reported in market milk by investigators, using radioimmunoassay and microbial receptor technology (hereafter referred to as the Charm II test). In response to these reports, an investigation was conducted to determine the potential of 3 extra-label routes of oxytetracycline (OTC) administration to cause milk residues above the Food and Drug Administration safe value of 30 parts per billion (ppb). Lactating Holstein cows were administered OTC once by use of 1 of 3 routes: IV at 16.5 mg/kg of body weight (n = 6); IM at 11 mg/kg (n = 6); and intrauterine (IU) at 2 g in 500 ml of saline solution/cow (n = 6). Duplicate milk samples were collected at the milking prior to drug administration and for the next 13 milkings at 12-hour intervals. Concentrations of OTC in milk samples were analyzed by use of the Charm II tes for tetracyclines (limit of OTC detection, approx 5 ppb) and were compared with concentrations determined by use of a high-performance liquid chromatography (HPLC) method (lower limit of OTC quantitation, approx 2 ppb). The potential for milk OTC residues above the Food and Drug Administration safe value of 30 ppb after treatment was considerably greater for the IV and IM routes, compared with the IU route.(ABSTRACT TRUNCATED AT 250 WORDS)     

Mechanical and morphometrical changes in progressive bilateral pneumothorax and pleural effusion in normal rats

A variety of neurotransmitter receptor changes occur after a course of electroconvulsive seizures (ECS) in rats, including an increased density of adenosine A1 sites. Adenosine antagonism has been related to the proconvulsant action of methylxanthines such as caffeine. We determined tonic-clonic seizure duration in rats given ECS with caffeine (0-175 mg/kg, IP) after a course of one or six daily ECS. A single day of ECS did not affect the dose-dependent proconvulsant action of caffeine. After six daily ECS, the proconvulsant action of caffeine was reduced. After nine daily ECS, an A1 antagonist (8-cyclopentyl-1,3-dipropylxanthine) and an A2A antagonist (1-allyl-3,7-dimethyl-8-p-sulfophenylxanthine) showed reduced proconvulsant activity. The results suggest that the reduced proconvulsant action of caffeine after chronic ECS depends on adenosine antagonism.