Operations standards for global ATM networks: network element view

The International Telecommunication Union (ITU) has completed work on a series of standards on asynchronous transfer mode (ATM) equipment functional operations and network element management. The objective of these standards is to enable flexible design and interoperability of network elements for use in a global ATM network, independent of any specific implementation. This article discusses these standards with respect to their development and application in planning ATM networks. Specifically, it addresses the following: the modeling approach taken in the development of the ITU standards, key operational features specified in the ATM network element functional model, and the capabilities of the ATM network element management interface. Examples of ATM equipment are provided to illustrate how the functional models specified in the ITU standards may be used by network planners and equipment manufacturers to specify and develop ATM equipment tailored to specific needs, while ensuring network interoperability. The article concludes with some points on the future enhancement of these and related ATM equipment operations standards     

激光熔覆用钴基合金粉末的研究

对激光熔覆用WFLC－11钴基合金粉末的激光熔覆工艺和熔覆层性能进行了研究，获得了WFLC－11钴基合金粉末激光熔覆层厚度与最小比能量关系曲线和熔覆层的组织、高温硬度等性能数据，为选择和使用WFLC－11钴基合金粉末提供了依据。     

Natural and induced tolerance in an immune network model

It has been proposed that the immune system can be partitioned into central and peripheral immune systems. Recently, Carneiro et al. (1996a, b) proposed a network, model incorporating B and T lymphocytes that explicitly accounts for that partition. This model however, had some limitations that are tackled here. Two main changes were introduced: the average idiotypic connectivity is now an explicit function of time based on empirical evidence; and the activation of T lymphocytes by antigen is described by a log-bell shaped dose response curve. The new model, which also accounts for the CIS and PIS distinction, shows more reasonable results since the frequencies of tolerant, immune or autoimmune responses to an antigen are now correct. The model provides a new interpretation for tolerance induction during the neonatal period, and for the adult tolerance by low or high doses of antigen. It predicts that natural tolerance for antigens available during the neonatal period can be kept indefinitely upon their removal, while tolerance induced in the adult stages is rapidly lost upon transient removal of the antigen. A semiquantitative analysis of the model provides a simple explanation for the different results in terms of the frequency at which a limited set of canonical connectivity structures emerge during ontogenesis.     

Synergistic decrease of clonal proliferation, induction of differentiation, and apoptosis of acute promyelocytic leukemia cells after combined treatment with novel 20-epi vitamin D3 analogs and 9-cis retinoic acid

Patients with acute promyelocytic leukemia (APL) usually relapse after all-trans retinoic acid (RA) treatment because this therapy fails to eradicate the malignant clone. Our data showed that KH 1060 and other 20-epi vitamin D3 analogs alone were potent inhibitors of clonal growth of NB4 cells, an APL cell line (ED50, approximately 5 x 10(-11) M). The combination of KH 1060 and 9-cis-RA synergistically and irreversibly enhanced this effect. Neither KH 1060 nor 9-cis-RA (10(-6) M, 3 d) were strong inducers of differentiation of NB4 cells. However, 98% of the cells underwent differentiation to a mature phenotype with features of both granulocytes and monocytes after exposure to a combination of both compounds. Apoptosis only increased after incubation of NB4 cells with 9-cis-RA alone (28%) or with a combination of 9-cis-RA plus KH1060 (32%). Immunohistochemistry showed that the bcl-2 protein decreased from nearly 100% of the wild-type NB4 cells to 2% after incubation with a combination of KH 1060 and 9-cis-RA, and the bax protein increased from 50% of wild-type NB4 cells to 92% after culture with both analogs (5 x 10(-7) M, 3 d). Western blot analysis paralleled these results. Studies of APL cells from one untreated individual paralleled our results with NB4 cells. Taken together, the data demonstrated that nearly all of the NB4 cells can be irreversibly induced to differentiate terminally when exposed to the combination of KH 1060 and 9-cis-RA.     

The effect of a two-week anti-orthostatic hypokinesia on the cardiac function and on the latter''s regulation in monkeys

Medical practice guidelines are being developed rapidly and advocated as a crucial component in transforming and improving the delivery of health care services. However, little is known about the ability of hospitals to institute guidelines outside of experimental settings. This article approaches guideline implementation from the viewpoint of process innovation assimilation and presents specific recommendations for organizational tactics leading to successful implementation of practice guidelines.     

一种相容决策表的属性值与属性约简方法

针对相容决策表,另辟一种数据约简思路,与传统数据约简方法不同的是,本文方法考虑属性值约简与属性约简之间的关联,该方法首先进行属性值约简,然后再进行属性约简,本文并给予了充分的证明,而普通的方法并没有考虑它们之间的联系,并有许多冗余的比较操作。     

BP网络模型对人脸朝向的识别

研究BP神经网络模型,通过计算机模拟人脑建立神经元网络,使用一部分人脸朝向信息作为训练的实例集,训练稳健后,可以推广应用判断其他人脸的朝向信息,以实现计算机自动识别人脸朝向。先对图片进行归一化等预处理,再应用主成分分析提取特征信息,每幅提取出的特征信息都是8个数据的列向量,构建一个8个输入、17个隐含、3个输出的三层BP网络模型。将训练实例集的特征向量代入训练,调整参数后保证其性能和收敛速度。最后通过大量实验验证,计算机识别的误判率仅为6.7%,模型可靠。