Investigation of atomic vapour deposited TiN/HfO2/SiO2 gate stacks for MOSFET devices

HfO₂ films were grown by atomic vapour deposition (AVD) on SiO₂/Si (1 0 0) substrates. The positive shift of the flat band voltage of the HfO₂ based metal-oxide-silicon (MOS) devices indicates the presence of negative fixed charges with a density of 5 × 10¹² cm⁻². The interface trap charge density of HfO₂/SiO₂ stacks can be reduced to 3 × 10¹¹ eV⁻¹ cm⁻² near mid gap, by forming gas annealing. The extracted work function of 4.7 eV preferred the use of TiN as metal gate for PMOS transistors. TiN/HfO₂/SiO₂ gate stacks were integrated into gate-last-formed MOSFET structures. The extracted maximum effective mobility of HfO₂ based PMOS transistors is 56 cm²/Vs.     

Wide temperature operation of 40-Gb/s 1550-nm electroabsorption modulated lasers

Electroabsorption modulated lasers (EMLs) exploiting the quantum confined Stark effect need thermoelectric coolers to achieve stable output power levels and dynamic extinction ratios. Temperature-independent operation is reported between 20/spl deg/C and 70/spl deg/C for InGaAlAs-InP-based monolithically integrated 1550-nm EMLs exploiting a shared active area at 40 Gb/s by actively controlling the electroabsorption modulator bias voltage. Dynamic extinction ratios of at least 8 dB and fiber-coupled mean modulated optical power of at least 0.85 mW are obtained over the mentioned temperature range.     

Retroviral vector-mediated transfer of the galactocerebrosidase (GALC) cDNA leads to overexpression and transfer of GALC activity to neighboring cells

Galactocerebrosidase (GALC) is responsible for the lysosomal catabolism of certain galactolipids, including galactosylceramide and psychosine. Patients with GALC deficiency have an autosomal recessive disorder known as globoid cell leukodystrophy (GLD) or Krabbe disease. Storage of undegraded glycolipids results in defective myelin and the characteristic globoid cells observed on pathological examination of the central and peripheral nervous systems. Most patients have the infantile form of GLD, although older individuals are also diagnosed. Recently the human, mouse, and canine GALC genes were cloned, and mutations causing GLD have been identified. We now describe the construction of a vector containing human GALC cDNA (MFG-GALC), and the transduction of cultured skin fibroblasts from molecularly characterized Krabbe disease patients, as well as rat brain astrocytes and human CD34(+) hematopoietic cells, using retrovirus produced by the psi-CRIP amphotropic packaging cell line. The transduced fibroblasts showed extremely high GALC activity (up to 20,000 times pretreatment levels, about 100 times normal). GALC was secreted into the media and was taken up by untransduced fibroblasts from the same or a different patient. Mannose-6-phosphate receptor-mediated uptake was only partially responsible for the efficient transfer of GALC to neighboring cells. Additional studies confirmed the presence of normal GALC cDNA and mRNA in the transduced cells. The GALC produced by the transduced cells and donated to neighboring untransduced cells was localized to lysosomes as demonstrated by the normal metabolism of [14C]stearic acid-labeled galactosylceramide produced from endocytosed [14C]sulfatide.     

Transduction of cultured oligodendrocytes from normal and twitcher mice by a retroviral vector containing human galactocerebrosidase (GALC) cDNA

We examined in mice the effect of chronic diazepam treatment on the sensitivity to isoflurane, and that of repeated isoflurane exposure on the sensitivity to diazepam. Mice were divided into four groups: group 1, treated with diazepam, 10 mg/kg i.p. twice daily; group 2, vehicle-treated controls; group 3, exposed to 3% isoflurane for 25 min twice daily; and group 4, untreated controls. After 14 days the effect of the treatment was assessed. Twenty-four hours after the last 10 mg/kg diazepam treatment, groups 1 and 2 received diazepam, 5 mg/kg i.p., and were subjected to the horizontal wire test (HWT). All control mice but only 10% of the diazepam-treated mice failed the HWT. Groups 1 and 2 were then exposed to increasing concentrations of isoflurane. Diazepam-treated mice (group 1) lost the HWT at 0.7+/-0.7%, compared with 0.6+/-0.1% in controls (group 2) (P<0.001); the ED50 was 0.75% vs. 0.65%. Group 1 mice lost the righting reflex at 0.94+/-0.07% isoflurane vs. 0.87+/-0.06% in group 2 (P<0.01); the ED50 was 0.93% vs. 0.82%. Recovery time was 175+/-161 s in group 1 vs. 343+/-275 s in group 2 (P<0.02). Twenty-four hours after the last of the repeated exposures to isoflurane, we examined the responses of groups 3 and 4 to increasing concentrations of isoflurane. Mice in group 3 lost the righting reflex at 1.0+/-0.06% isoflurane vs. 0.9+/-0.04% in controls (group 4) (P<0.001); the ED50 was 0.96% vs. 0.85%. Recovery time was 113+/-124 s vs. 208+/-126 s in groups 3 and 4 (P<0.09). Diazepam, 3 mg/kg i.p. administered to groups 3 and 4, caused loss of the HWT reflex in 33% of group 3 mice and in 82% of controls (group 4) (P<0.001). It appears that prolonged exposure to both diazepam and isoflurane caused reduced sensitivity to each drug separately, as well as to the other drug. This finding may strengthen the theory that inhalational anesthetics may act via the same mechanism as the benzodiazepines.     

Soft Magnetic Properties of Fe - (1 wt.%) Al Alloy Processed by Powder Metallurgy

A soft magnetic material (iron with 1 wt.% aluminum) has been developed using a powder metallurgy processing route. The addition of aluminum in iron has resulted in an alloy with significant grain growth during sintering and correspondingly superior magnetic properties characterized by a low coercivity (H_c≈0.9 Oe), a relatively high permeability (μ_max ≈ 5000) and a high saturated magnetic induction (B_s ≈ 13 kG at 8 Oe) after sintering at 1482°C for 12 hours. The effects of sintering time and temperature on the magnetic properties of this alloy have also been examined.     

Diffusion in liquid in-Sn alloys at 300° C

Binary diffusion coefficients were measured as a function of composition in liquid indiumtin at 300°C using a modified capillary-reservoir procedure. The coefficient variation with atom fraction may be expressed by the relationD × 10⁵(cm² per sec) = 3.06−2.18 N_In + 2.24 N _In ²     

The future for applied psychology: Are we building a buggy whip factory?

A review of current theoretical and practical issues and previous findings from a study of counseling psychologists show that the role of applied psychology is ill-defined, usually stated as what professionals are doing, and reflects the conflict of collecting and reporting scientific data vs. professional practice. Training should acknowledge that professional scientific knowledge is dynamic, acquired by a liberal education through a life-long process. Future models may see the role of the applied psychologist as mediating the scientific search for knowledge with the priorities of solving problems in the community. (42 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)