Question answer selection in the Chinese medical field is very challenging since it requires effective text representations to capture the complex semantic relationships between Chinese questions and answers. Recent approaches on deep learning, e.g., CNN and RNN, have shown their potential in improving the selection quality. However, these existing methods can only capture a part or one-side of semantic relationships while ignoring the other rich and sophisticated ones, leading to limited performance improvement. In this paper, a series of neural network models are proposed to address Chinese medical question answer selection issue. In order to model the complex relationships between questions and answers, we develop both single and hybrid models with CNN and GRU to combine the merits of different neural network architectures. This is different from existing works that can onpy capture partial relationships by utilizing a single network structure. Extensive experimental results on cMedQA dataset demonstrate that the proposed hybrid models, especially BiGRU-CNN, significantly outperform the state-of-the-art methods. The source codes of our models are available in the GitHub (https://github.com/zhangyuteng/MedicalQA-CNN-BiGRU).
Efficient delivery of genes and therapeutic agents to the interior of the cell is critical for modern biotechnology. Herein, a new type of chemical‐free cell poration method—hypersonic poration—is developed to improve the cellular uptake, especially the nucleus uptake. The hypersound (≈GHz) is generated by a designed piezoelectric nano‐electromechanical resonator, which directly induces normal/shear stress and “molecular bombardment” effects on the bilayer membranes, and creates reversible temporal nanopores improving the membrane permeability. Both theory analysis and cellular uptake experiments of exogenous compounds prove the high delivery efficiency of hypersonic poration. Since target molecules in cells are accumulated with the treatment, the delivered amount can be controlled by tuning the treatment time. Furthermore, owing to the intrinsic miniature of the resonator, localized drug delivery at a confined spatial location and tunable arrays of the resonators that are compatible with multiwell plate can be achieved. The hypersonic poration method shows great delivery efficacy combined with advantage of scalability, tunable throughput, and simplification in operation and provides a potentially powerful strategy in the field of molecule delivery, cell transfection, and gene therapy. 相似文献
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