Management and enterprise architecture click: The FAD(E)E framework

Enterprises are living things. They constantly need to be (re-)architected in order to achieve the necessary agility, alignment and integration. This paper gives a high-level overview of how companies can go about doing ‘enterprise architecture’ in the context of both the classic (isolated) enterprise and the Extended Enterprise. By discussing the goals that are pursued in an enterprise architecture effort we reveal some basic requirements that can be put on the process of architecting the enterprise. The relationship between managing and architecting the enterprise is discussed and clarified in the FAD(E)E, the Framework for the Architectural Development of the (Extended) Enterprise. Frank G. Goethals completed his Master studies in economics (option informatics), at the Katholieke Universiteit Leuven, Belgium, in 2000. He is presently researching for a Ph.D. under the theme of `Managing data in the Extended Enterprise'. This research is conducted at the K.U.Leuven under the guidance of professor J. Vandenbulcke, and is financed by SAP Belgium. Frank has a strong interest in coordination and dependency theory and Enterprise Architecture. Monique Snoeck obtained her Ph.D. in May 1995 from The Department of Computer Science of the Katholieke Universiteit Leuven with a thesis that lays the formal foundations of the object-oriented business modelling method MERODE. Since then she has done further research in the area of formal methods for object-oriented conceptual modelling. She now is Full Professor with the Management Information Systems Group of the Faculty of Economics and Applied Economics at the Katholieke Universiteit Leuven in Belgium. She has been involved in several industrial conceptual modelling projects. Her research interests are object oriented conceptual modelling, software architecture and software quality. Wilfried Lemahieu holds a Ph.D. from the Department of Applied Economic Sciences of the Katholieke Universiteit Leuven, Belgium (1999). At present, he is associate professor at the Management Informatics research group of the Faculty of Economics and Applied Economics. His teaching includes Database Management, Data Storage Architectures and Management Informatics. His research interests comprise distributed object architectures and web services, object-relational and object-oriented database systems and hypermedia systems. Jacques A. Vandenbulcke is professor at the Faculty of Economics and Applied Economics of the Katholieke Universiteit Leuven, Belgium. His main research interests are in Database management, Data modelling, and Business Information Systems. He is co-ordinator of the Leuven Institute for Research on Information Systems (LIRIS) and holder of the SAP-chair on ‘Extended enterprise infrastructures’. He is president of ‘Studiecentrum voor Automatische Informatieverwerking (SAI)’, the largest society for computer professionals in Belgium, and co-founder of the ‘Production and Inventory Control Society (PICS)’ in Belgium.     

Energy transfer in hydrogen/air and methane/air mixtures

This article presents gas kinetic calculation methods for the energy transport in hydrogen/ air and methane/ air mixture. The total molecular heat conductivity as well as its various shares are calculated and discussed for a temperature range of 400 to 3500 K and for a pressure of 10⁵ Pa. The variation of the air/ fuel ratio under the conditions of chemical equilibrium is also investigated. As opposed to our previous article, an extension of the Chapman-Knskog method which goes beyond the classical 1st approximation for elastic collisions is applied for the evaluation of suitable calculation methods. This is carried out following the method for strong relaxing thermal nonequilibrium according to Brun. The equations applied in this work are simplified formulations for the proximity to equilibrium. The method for the evaluation of the parameters of the inelastic collision and some chosen results are presented. A discussion of the various shares of the molecular heat conductivity emphasizes the considerable influence of the diffusion and the thermal diffusion processes in fuel/ air mixtures compared to the Fourier heat conductivity.     

End-of-life impacts of pervasive computing

RFID technology is one of the forerunners of pervasive computing, and as such is expected to play an important role in many applications of daily life, especially in the form of smart labels. However, market investigations and a material analysis of a smart label shows that the use of smart labels does not considerably affect the recycling or disposal of packaging materials, if precautionary measures are taken, such as eco-design and, where necessary process modifications. Today in industrialized countries end-of-life information and communication technology (ICT) equipment is processed separately from other waste streams, given its material composition and appliance size. The waste management processes studied are municipal solid waste incineration and recycling of glass, paper, cardboard, polyethylene terephthalate (PET) and aluminum.     

IL-2 adenovector-transduced autologous tumor cells induce antitumor immune responses in patients with neuroblastoma

In many different murine models, the immunogenicity of tumor cells can be increased by transduction with a range of immunostimulatory genes, inducing an immune response that causes regression of pre-existing unmodified tumor cells. To investigate the relevance of these animal models to pediatric malignancy, we used autologous unirradiated tumor cells transduced with an adenovirus-IL-2 to immunize 10 children with advanced neuroblastoma. In a dose-escalation study, we found that this tumor immunogen induced a moderate local inflammatory response consisting predominantly of CD4(+) T lymphocytes, and a systemic response, with a rise in circulating CD25(+) and DR+ CD3(+) T cells. Patients also made a specific antitumor response, manifest by an IgG antitumor antibody and increased cytotoxic T-cell killing of autologous tumor cells. Clinically, five patients had tumor responses after the tumor immunogen alone (one complete tumor response, one partial response, and three with stable disease). Four of these five patients were shown to have coexisting antitumor cytotoxic activity, as opposed to only one of the patients with nonresponsive disease. These results show a promising correlation between preclinical observations and clinical outcome in this disease, and support further exploration of the approach for malignant diseases of children.     

Transient behaviour of shell and tube heat exchangers

Based on the dispersion model rather than on the conventional pluf-flow model, a method of predicting the transient behaviour of parallel and counterflow heat exchangers is developed, whereby the effects of shell-side flow maldistribution and the finite heat capacities of both fluids, tube bundle and shell are considered. The final solution has been obtained by numerical inversion of the Laplace transform, to determine the transient responses to arbitrary inlet temperature variations. The experiment was carried out in a one pass tube heat exchanger. The comparison between therotical and experimental results is presented and the feasibility of this method is discussed.